Fagioli Claudio

Senior Labmanager

Publications:

A dynamic study of protein secretion and aggregation in the secretory pathway.

Mossuto MF, Sannino S, Mazza D, Fagioli C, Vitale M, Yoboue ED, Sitia R, Anelli T.

PLoS One. 2014 Oct 3;9(10):e108496. doi: 10.1371/journal.pone.0108496. eCollection 2014.

Progressive quality control of secretory proteins in the early secretory compartment by ERp44.

Sannino S, Anelli T, Cortini M, Masui S, Degano M, Fagioli C, Inaba K, Sitia R.

J Cell Sci. 2014 Oct 1;127(Pt 19):4260-9. doi: 10.1242/jcs.153239. Epub 2014 Aug 5.

Different redox sensitivity of endoplasmic reticulum associated degradation clients suggests a novel role for disulphide bonds in secretory proteins.

Medraño-Fernandez I, Fagioli C, Mezghrani A, Otsu M, Sitia R.

Biochem Cell Biol. 2014 Apr;92(2):113-8. doi: 10.1139/bcb-2013-0090. Epub 2014 Feb 4

A pH-regulated quality control cycle for surveillance of secretory protein assembly.

Vavassori S, Cortini M, Masui S, Sannino S, Anelli T, Caserta IR, Fagioli C, Mossuto MF, Fornili A, van Anken E, Degano M, Inaba K, Sitia R.

Mol Cell. 2013 Jun 27;50(6):783-92. doi: 10.1016/j.molcel.2013.04.016. Epub 2013 May 16

Dynamic regulation of Ero1α and peroxiredoxin 4 localization in the secretory pathway.

Kakihana T, Araki K, Vavassori S, Iemura S, Cortini M, Fagioli C, Natsume T, Sitia R, Nagata K.

J Biol Chem. 2013 Oct 11;288(41):29586-94. doi: 10.1074/jbc.M113.467845. Epub 2013 Aug 26

Plasma cells require autophagy for sustainable immunoglobulin production.

Pengo N, Scolari M, Oliva L, Milan E, Mainoldi F, Raimondi A, Fagioli C, Merlini A, Mariani E, Pasqualetto E, Orfanelli U, Ponzoni M, Sitia R, Casola S, Cenci S.

2013 Mar;14(3):298-305. doi: 10.1038/ni.2524. Epub 2013 Jan 27.

23354484 [PubMed - indexed for MEDLINE]

Ero1α regulates Ca(2+) fluxes at the endoplasmic reticulum-mitochondria interface (MAM).

Anelli T, Bergamelli L, Margittai E, Rimessi A, Fagioli C, Malgaroli A, Pinton P, Ripamonti M, Rizzuto R, Sitia R.

Antioxid Redox Signal. 2012 May 15;16(10):1077-87. Epub 2011 Oct 19.

PMID: 21854214

Molecular bases of cyclic and specific disulfide interchange between human ERO1alpha protein and protein-disulfide isomerase (PDI).

Masui S, Vavassori S, Fagioli C, Sitia R, Inaba K.

J Biol Chem. 2011 May 6;286(18):16261-71. Epub 2011 Mar 11.

PMID: 21398518 [PubMed - indexed for MEDLINE]

Pathogenesis of ER storage disorders: modulating Russell body biogenesis by altering proximal and distal quality control.

Ronzoni R, Anelli T, Brunati M, Cortini M, Fagioli C, Sitia R.

Traffic. 2010 Jul 1;11(7):947-57. Epub 2010 Apr 6. Erratum in: Traffic. 2010 Oct;11(10):1380.

PMID: 20406418 [PubMed - indexed for MEDLINE]

CHOP-independent apoptosis and pathway-selective induction of the UPR in developing plasma cells.

Masciarelli S, Fra AM, Pengo N, Bertolotti M, Cenci S, Fagioli C, Ron D, Hendershot LM, Sitia R.

Mol Immunol. 2010 Mar;47(6):1356-65. Epub 2009 Dec 30.

PMID: 20044139 [PubMed - indexed for MEDLINE]

SEL1L and HRD1 are involved in the degradation of unassembled secretory Ig-mu chains.

Cattaneo M, Otsu M, Fagioli C, Martino S, Lotti LV, Sitia R, Biunno I.

J Cell Physiol. 2008 Jun;215(3):794-802.

PMID: 18314878 [PubMed - indexed for MEDLINE]

ER storage diseases: a role for ERGIC-53 in controlling the formation and shape of Russell bodies.

Mattioli L, Anelli T, Fagioli C, Tacchetti C, Sitia R, Valetti C.

J Cell Sci. 2006 Jun 15;119(Pt 12):2532-41. Epub 2006 May 30.

PMID: 16735443 [PubMed - indexed for MEDLINE] Free Article

Dynamic retention of Ero1alpha and Ero1beta in the endoplasmic reticulum by interactions with PDI and ERp44.

Otsu M, Bertoli G, Fagioli C, Guerini-Rocco E, Nerini-Molteni S, Ruffato E, Sitia R.

Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):274-82.

PMID: 16677073 [PubMed - indexed for MEDLINE]

Glutathione limits Ero1-dependent oxidation in the endoplasmic reticulum.

Molteni SN, Fassio A, Ciriolo MR, Filomeni G, Pasqualetto E, Fagioli C, Sitia R.

J Biol Chem. 2004 Jul 30;279(31):32667-73. Epub 2004 May 25.

PMID: 15161913 [PubMed - indexed for MEDLINE] Free Article

The making of a professional secretory cell: architectural and functional changes in the ER during B lymphocyte plasma cell differentiation.

Tagliavacca L, Anelli T, Fagioli C, Mezghrani A, Ruffato E, Sitia R.

Biol Chem. 2003 Sep;384(9):1273-7. Review.

PMID: 14515988 [PubMed - indexed for MEDLINE]

Reduction of interchain disulfide bonds precedes the dislocation of Ig-mu chains from the endoplasmic reticulum to the cytosol for proteasomal degradation.

Fagioli C, Mezghrani A, Sitia R.

J Biol Chem. 2001 Nov 2;276(44):40962-7. Epub 2001 Aug 30.

PMID: 11533039 [PubMed - indexed for MEDLINE] Free Article

Glycoprotein quality control in the endoplasmic reticulum. Mannose trimming by endoplasmic reticulum mannosidase I times the proteasomal degradation of unassembled immunoglobulin subunits.

Fagioli C, Sitia R.

J Biol Chem. 2001 Apr 20;276(16):12885-92. Epub 2001 Jan 24.

PMID: 11278527 [PubMed - indexed for MEDLINE] Free Article

Degradation of unassembled soluble Ig subunits by cytosolic proteasomes: evidence that retrotranslocation and degradation are coupled events.

Mancini R, Fagioli C, Fra AM, Maggioni C, Sitia R.

FASEB J. 2000 Apr;14(5):769-78.

PMID: 10744633 [PubMed - indexed for MEDLINE] Free Article

Biogenesis and function of IgM: the role of the conserved mu-chain tailpiece glycans.

de Lalla C, Fagioli C, Cessi FS, Smilovich D, Sitia R.

Mol Immunol. 1998 Sep;35(13):837-45.

PMID: 9839552 [PubMed - indexed for MEDLINE]

Assembly and secretion of antibodies during B cell development.

Maggioni C, Carelli S, Cabibbo A, Fagioli C, Fra AM, Sitia R.

Bratisl Lek Listy. 1998 Aug-Sep;99(8-9):419-25. Review. No abstract available.

PMID: 9810765 [PubMed - indexed for MEDLINE]

Differential expression of Galalpha1,3Gal epitope in polymeric and monomeric IgM secreted by mouse myeloma cells deficient in alpha2, 6-sialyltransferase.

Smilovich D, Malagolini N, Fagioli C, de Lalla C, Sitia R, Serafini-Cessi F.

Glycobiology. 1998 Aug;8(8):841-8.

PMID: 9637816 [PubMed - indexed for MEDLINE]

Formation of reversible disulfide bonds with the protein matrix of the endoplasmic reticulum correlates with the retention of unassembled Ig light chains.

Reddy P, Sparvoli A, Fagioli C, Fassina G, Sitia R.

EMBO J. 1996 May 1;15(9):2077-85.

PMID: 8641273 [PubMed - indexed for MEDLINE]

Quality control of ER synthesized proteins: an exposed thiol group as a three-way switch mediating assembly, retention and degradation.

Fra AM, Fagioli C, Finazzi D, Sitia R, Alberini CM.

EMBO J. 1993 Dec;12(12):4755-61.

PMID: 8223484 [PubMed - indexed for MEDLINE]