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Lab manager, former postdoc, former PhD student, former Londoner, former tutor, currently assistant lecturer for the Course of Cell Biology, Master degree in Biotechnologies
When not busy answering some kind of weird question or dealing with unusual requests, he sets and solves crosswords and organises the Division Biolympic games
Selected Publications
Vitale M*, Bakunts A*, Orsi A, Lari F, Tadè L,Danieli A , Rato C, Valetti C, Sitia R, Raimondi A, Christianson JC, van Anken E Inadequate BiP availability defines endoplasmic reticulum stress. Elife. 2019 in the press
Bakunts A*, Orsi A*, Vitale M*, Cattaneo A, Lari F, Tadè L, Sitia R, Raimondi A, Bachi A, van Anken E. Ratiometric sensing of BiP-client versus BiP levels by the unfolded protein response determines its signaling amplitude. – Elife. 2017
Cohen N, Breker M, Bakunts A, Pesek K, Chas A, Argemí J, Orsi A, Gal L, Chuartzman S, Wigelman Y, Jonas F, Walter P, Ernst R, Aragón T, van Anken E, Schuldiner M. Iron affects Ire1 clustering propensity and the amplitude of endoplasmic reticulum stress signaling. – J Cell Sci. 2017
van Anken E, Orsi A, Sitia R. A RIDDle solved: why an intact IRE1α/XBP-1 signaling relay is key for humoral immune responses. – Eur J Immunol. 2014
Orsi A, Razi M, Dooley HC, Robinson D , Weston AE, Collinson LM, Toose SA Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, is required for autophagy – Mol Biol Cell. 2012
Longatti A, Orsi A, Tooze SA. Autophagosome formation: not necessarily an inside job. – Cell Res. 2010
Orsi A, Polson HE, Tooze SA Membrane trafficking events that partake in autophagy. – Curr Opin Cell Biol. 2009 Review
Bianchi G, Oliva L, Cascio P, Pengo N, Fontana F, Cerruti F, Orsi A, Pasqualetto E, Mezghrani A, Calbi V, Palladini G, Giuliani N, Anderson KC, Sitia R, Cenci S. The proteasome load versus capacity balance determines apoptotic sensitivity of multiple myeloma cells to proteasome inhibition. – Blood. 2009
Orsi A, Sitia R. Interplays between covalent modifications in the endoplasmic reticulum increase conformational diversity in nascent prion protein. – Prion. 2007
Cenci S, Mezghrani A, Cascio P, Bianchi G, Cerruti F, Fra A, Lelouard H, Masciarelli S, Mattioli L, Oliva L, Orsi A, Pasqualetto E, Pierre P, Ruffato E, Tagliavacca L, Sitia R. Progressively impaired proteasomal capacity during terminal plasma cell differentiation. – EMBO J. 2006
Orsi A, Fioriti L, Chiesa R, Sitia R. Conditions of endoplasmic reticulum stress favor the accumulation of cytosolic prion protein. – J Biol Chem. 2006
Orsi A, Sparvoli F, Ceriotti A. Role of individual disulfide bonds in the structural maturation of a low molecular weight glutenin subunit. – J Biol Chem. 2001
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