Abstract

FoThe ASCT2 transporter (SLC1A5) is a sodium-dependent neutral amino acid transporter. Inhibition of the glutamine transport into the cell provides a potential cancer therapy. The molecule, Lc-BPE, has been identified as an effective inhibitor with a low Ki value and a high binding affinity for the binding site of ASCT2. Here, derivatives of the Lc-BPE compound have been synthesized using thioproline scaffolds. Lc-BPE had the secondary amine in position 4 of the proline ring. The derived compounds had the secondary amine in position 5 of the proline ring, as well as the addition of a heteroatom in position 2. The synthesized compounds provide a framework for the testing of their effectiveness as inhibitors. od insecurity is a rising issue among college students. The added pressure and worry over food availability impacts students’ mindset and their perception of stress. However, research investigating this relationship is limited. To address this gap, an anonymous online survey was distributed via social media platforms to adults 18 years and older. The survey included demographic questions, the Food Mood Questionnaire, and the Perceived Stress Scale. A total of 997 people completed the survey, including 705 females, 246 males, and 46 others. Data was analyzed using Pearson’s Correlation Coefficient in SPSS Version 25.0. A significant positive correlation was found between food insecurity and perceived stress (p<0.01). Significant negative correlations between the consumption of dark green leafy vegetables and fruit with perceived stress (p<0.01) were also found. This suggests that students experiencing food insecurity may consume less nutritious foods and perceive themselves as more stressed.