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Effects of Acute and Repeated Alcohol Exposure on Expression of Synaptic-Associated Genes in the Male and Female Mouse mPFC
Effects of Acute and Repeated Alcohol Exposure on Expression of Synaptic-Associated Genes in the Male and Female Mouse mPFC
Authors: Dhruba Podder, C. Coble, FP Varodayan
Authors: Dhruba Podder, C. Coble, FP Varodayan
Field of Study: Science, Technology, Engineering, and Math
Field of Study: Science, Technology, Engineering, and Math
Affiliation: Undergraduate Research Award
Affiliation: Undergraduate Research Award
Mentor: Florence Varodayan, Psychology
Mentor: Florence Varodayan, Psychology
Abstract
Abstract
Alcohol use disorder (AUD) is a serious chronic brain disease; in 2019 there were ~14.5 million people in the U.S. diagnosed with AUD. Individuals with AUD often show cognitive impairment such as risky decision-making, difficulties with impulse control, and working memory deficits. The hallmark cognitive impairment exhibited by AUD patients is associated with structural and functional changes in the mPFC. The purpose of this study was to investigate how acute and repeated alcohol exposure modify the gene expression of synaptic vesicle-associated proteins, including HSF1, VAMP1, VAMP2, and Syt1 in the mPFC of mice. Through qPCR, we found significant sex and alcohol exposure differences in the expression of Hsf1, Vamp1, Vamp2, and Syt1. In the future, expression of postsynaptic GABA and glutamate receptors should be investigated.m
Alcohol use disorder (AUD) is a serious chronic brain disease; in 2019 there were ~14.5 million people in the U.S. diagnosed with AUD. Individuals with AUD often show cognitive impairment such as risky decision-making, difficulties with impulse control, and working memory deficits. The hallmark cognitive impairment exhibited by AUD patients is associated with structural and functional changes in the mPFC. The purpose of this study was to investigate how acute and repeated alcohol exposure modify the gene expression of synaptic vesicle-associated proteins, including HSF1, VAMP1, VAMP2, and Syt1 in the mPFC of mice. Through qPCR, we found significant sex and alcohol exposure differences in the expression of Hsf1, Vamp1, Vamp2, and Syt1. In the future, expression of postsynaptic GABA and glutamate receptors should be investigated.m
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