We recently published a paper looking at differences between cycling and running in terms of acute changes in cartilage thickness. In this preliminary study where we controlled mechanical power during each mode of exercise, no differences were observed between 15-min of cycling or running at the same power output. This result indicates that, if power production during cycling or running are equivalent, the tibiofemoral cartilage may respond similarly during the exercise. Interestingly, both types of exercises led to an increase in cartilage thickness after 5-min from completion of the exercise, which could be associated with an increase in synovial fluid. It is important to note that these responses were observed for non-athletes, which cannot be extrapolated to cyclists, runners or triathletes until further studies are conducted.