In the year 2025 A.D., robots have become commonplace, performing menial tasks and working in industry. For that, the world can thank the young genius robotic engineer Ziv "ZZ" Zulander and the Robotic Megafact Corporation (aka RM Corp) he works for. Ziv's creation of the "3A robot series" revolutionized the world and its application of robotics. However, Sir Lewis Leon Paradim (aka "LLP", president of RM Corp) isn't satisfied being one of the wealthiest men in the world; he desires world domination. With his assistants Lady Frenzy and Dr. Hiss, LLP plans to take control of the planet through a coup, using the very same 3A bots that ZZ had invented to benefit humanity. Dr. Hiss creates a new chip, called the "Krang Chip", which can be used to override any 3A series robot to take orders exclusively from RM Corp. ZZ learns of LLP's evil plan and decides to defect from the company, intending to stop the continued manufacture and distribution of the Krang Chips.

LLP and his cohorts originally seek to capture ZZ and attempt to convince him to switch sides, but ZZ refuses. Utilizing his A.I. robotic creations, the B.O.Y.Z.Z. (Brain Operated Young Zygoetopic Zoids), Zulander stages a robotic guerrilla war against RM Corps' military bots. Shortly after escaping RM Corp, ZZ rescues his sister Blitzy Zulander and takes his home and operation literally underground to avoid enemy detection. After securing his base of operations, ZZ and his BOYZZ begin their private campaign against RM Corp.

ZZ had secretly installed a special system, called "mirrors", which allows him to monitor RM Corp from within Lady Frenzy's office PC, using this information to sabotage RM Corp plans. During attempts to foil Krang Chip delivery and production, ZZ and his BOYZZ are incriminated in a series of false media reports on his rogue activities to turn public sympathy against him, and discrediting his heroic efforts as terrorism activity.

During the second half of the series, LLP begins his campaign to run for President of the World

Street Boyzz (Jammerzz & Toolzz):

Greetings from the Street Boyzz

Jammerzz:

You know the planet is in a jam

A diabolical plan of only one man

Louis Leon Paradim an international punk

and his army of 3As are his piece of junk

Toolzz:

Yeah! Well he can't fade us

He forgot about the Boyzz and the guy who made us

Ziv Zulander, master of Boyzz bots

Street Boyzz (Jammerzz & Toolzz):

We undermine the plot

Sports Boyzz (Ace, Batzz & All Ball):

We're the Sports Boyzz and we like making noise

Commander jock has intelligent droids

Cook:

I'm cook, and I can take the heat

But don't forget, you are what you eat

Watzon:

Call me Watzon, let me swivel and say

I rock in the doc and I save the day

D'Nerd:

And D'Nerd is my name

And the brain is my game

Genesix:

In addition to the credits, every episode of the show had a short segment in 3D. Using a method called the Pulfrich effect, the segment was acceptable for viewers with or without the special glasses packaged with action figures based on the series. To inform viewers to wear their glasses, a character - usually Zulander - would shout, "Lazer Time, boyzz!" followed by an image of the 3-D glasses on the screen. Once the 3-D sequence was over, ZZ would call "Game Over!" and an image of the 3-D glasses appear once more on the screen, this time with a no symbol superimposed over it. For the Bots Master series the effect was produced by Nuoptix 3-D.