William_and_Marry 2021
Orthogonality
Project Description:
Although orthogonality is a key tenet of synthetic biology, methods that assess orthogonality are relatively scarce in iGEM projects and in synthetic biology literature. We aim to create a model that will help teams quantify unwanted host-circuit interactions, providing an orthogonality metric. Using the data from our model, our team will also design a sensor circuit that allows other iGEM teams to obtain a preliminary orthogonality assessment of their circuits.
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Our project targets one Sustainable Development Goal: Goal #9: Industry, Innovation and Infrastructure. More specifically, the goal we would like to emphasize are sub-goal 9.5.
Task 1: We have created a 5-question, anonymous survey relevant to our project to give us an idea of how many iGEM teams consider orthogonality, crosstalk, or burden when designing genetic circuits and how many teams assess the orthogonality of their circuits.
This survey will help to enhance scientific research within iGEM through a discussion about considering the orthogonality of genetic circuits throughout the circuit design process and assessing the orthogonality of genetic circuits, as orthogonality is a key tenet and guiding principle of synthetic biology that is crucial to the safety and functionality of all circuits.
CONTACT INFORMATION:
Instagram: @igem_wm
Email: igem@wm.edu, bnabuageel@email.wm.edu
TikTok: @igem_wm