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Df.: "Эпигенетический признак - стабильно наследуемый фенотип, в результате изменений в хромосоме без изменения в последовательности ДНК"

Definition: “An epigenetic trait is a stably heritable phenotype resulting from changes in a chromosome without alterations in the DNA sequence.”

Shelley L. Berger, Tony Kouzarides, Ramin Shiekhattar, and Ali Shilatifard. An operational definition of epigenetics // Genes & Dev. 2009. 23: 781-783.

Figure 1. Berger SL, Kouzarides T, Shiekhattar R, Shilatifard A. An operational definition of epigenetics // Genes Dev. 23 (7): 781–3 (2009).

The epigenetic pathway. Three categories of signals are proposed to operate in the establishment of a stably heritable epigenetic state. An extracellular signal referred to as the “Epigenator” (shown in blue) originates from the environment and can trigger the start of the epigenetic pathway. The “Epigenetic Initiator” (shown in red) receives the signal from the “Epigenator” and is capable of determining the precise chromatin location and/or DNA environment for the establishment of the epigenetic pathway. The “Epigenetic Maintainer” (shown in green) functions to sustain the chromatin environment in the initial and succeeding generations. Persistence of the chromatin milieu may require cooperation between the Initiator and the Maintainer. Examples for each category are shown below each heading. Chromatin is depicted in blue.

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In 2008, a consensus definition of the epigenetic trait, "stably heritable phenotype resulting from changes in a chromosome without alterations in the DNA sequence", was made at a Cold Spring Harbor meeting.^[11]

11. Berger SL, Kouzarides T, Shiekhattar R, Shilatifard A (2009). "An operational definition of epigenetics". Genes Dev. 23 (7): 781–3.doi:10.1101/gad.1787609. PMID 19339683