08/11/2010 - US EPA IRIS Report on 1,4-dioxane Human Health Assessment

The Environmental Protection Agency (EPA) August 11, 2010, published the Integrated Risk Information System Assessment for 1,4 dioxane. This assessemt developed a revised cancer slope factor Carcinogenicity Assessment for Lifetime Exposure

• • Weight-of-Evidence Characterization

    • • Likely to be carcinogenic to humans

  • Weight-of-Evidence Narrative:

    • • In accordance with the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005, 1,4-dioxane is characterized as "likely to be carcinogenic to humans."

      • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

  • Quantitative Estimate of Carcinogenic Risk from Oral Exposure

*The unit risk and concentration estimates assume water consumption of 2 L/day by a 70 kg human.