Matteo Lambrughi

I am Post-Doctoral Researcher at CBL.I have a solid background in biology, biophysics and biochemistry thank to my studies and research activities during my Master's degree and Ph.D. in Industrial Biotechnology at the University of Milano Bicocca (UniMiB, Milan, Italy) under the supervision of Dr. Elena Papaleo and Prof. Luca De Gioia. Thanks to my supervisors I developed solid expertise in computational biochemistry of biomolecules. I also acquired deep knowledge of quantum mechanics approaches, thanks to Prof. Maurizio Bruschi at the UniMiB, and robust experience in experimental and biochemical methods in structural biology of proteins thanks to collaboration with the group of Prof. Paolo Tortora at the UniMiB and the group of Prof. Kaare Teilum at University of Copenhagen, Denmark, under the supervision of Dr. Gaetano Invernizzi.

I am involved in a few research lines at CBL using an integrated approach of quantum chemical methods and molecular simulations to explore biological problems in the field of cancer research and tumorigenic agents. The projects are focused on the structural and functional study of cancer-related proteins, such as molecular chaperones and DNA-binding domains of transcription factors. We aim at investigating how mutations, post-translational modifications and the interaction with biological partners, affect their dynamics, functional motions and the association with cancer.

We recently moved our attention to methods to predict new short linear motifs or new binding domains, which underlying new moonlight functions in already known proteins. We are applying these methods to the prediction of microtubule binding domains, RNA-binding domains in DNA-binding proteins, and membrane proteins that can be modulated by sphingomyelin.

I am also working, using NMR spectroscopy integrated to molecular simulations, on intrinsically disordered proteins of interest for CBL. We use the facilities at the University of Copenhagen and work in close collaboration with Prof. Birthe Kragelund, a worldwide expert in the field of structural biology of IDPs.

We work on these topics in collaboration with the experimental groups lead by Prof. Francesco Cecconi and Dr. Giuseppe Filomeni (Unit of Cell Stress and Survival, DCRC), Prof. Marja Jaattela and Dr. Tuula Kallunki (Unit of Cell Death and Metabolism, DCRC), Dr. Marin Barisic (Cell Division Lab).

Scientific publications:

12 original research articles and reviews on peer-reviewed journals (161 citations, H-index = 8)

Additional information:

https://www.researchgate.net/profile/Matteo_Lambrughi

https://scholar.google.it/citations?user=isWXw-sAAAAJ&hl=it