Bioinformatic Support

Our group also provides bioinformatics support for colleagues at the Danish Cancer Society Research Center and outside using state-of-the-art methods in many fields of bioinformatics at all stages of a research project. We carry out these tasks with a solid biological background and also a research-oriented spirit. This includes analyses of high-throughput data set (such as the ones from proteomics, transcriptomics, microRNA…), cancer databases, analyses of single-nucleotide polymorphisms and cancer-related aberration, clustering methods and data mining, differential expression analyses, molecular modeling, simulations and bio-network analyses. We offer our support at all the stages of a research project including experimental design, prediction, data analyses, and publications. A list of packages and examples is reported in the document attached below. Please contact us for further information.

Similar analyses have been recently contributed to important publications such as:

1. Predicting the impact of Lynch syndrome-causing missense mutations from structural calculations. Nielsen SV, Stein A, Dinitzen AB, Papaleo E, Tatham MH, Poulsen EG, Kassem MM, Rasmussen LJ, Lindorff-Larsen K, Hartmann-Petersen R.

PLoS Genet. 2017 Apr 19;13(4):e1006739.

2. Cytokine profiling of tumor interstitial fluid of the breast and its relationship with lymphocyte infiltration and clinicopathological characteristics.

Espinoza JA, Jabeen S, Batra R, Papaleo E, Haakensen V, Timmermans Wielenga V, Møller Talman ML, Brunner N, Børresen-Dale AL, Gromov P, Helland Å, Kristensen VN, Gromova I.

Oncoimmunology. 2016 Oct 24;5(12):e1248015

3. Absence of Neurofibromin Induces an Oncogenic Metabolic Switch via Mitochondrial ERK-Mediated Phosphorylation of the Chaperone TRAP1.

Masgras I, Ciscato F, Brunati AM, Tibaldi E, Indraccolo S, Curtarello M, Chiara F, Cannino G, Papaleo E, Lambrughi M, Guzzo G, Gambalunga A, Pizzi M, Guzzardo V, Rugge M, Vuljan SE, Calabrese F, Bernardi P, Rasola A.

Cell Rep. 2017 Jan 17;18(3):659-672

4. MIR7-3HG, a MYC-dependent modulator of cell proliferation, inhibits autophagy by a regulatory loop involving AMBRA1.

Capizzi M, Strappazzon F, Cianfanelli V, Papaleo E, Cecconi F.

Autophagy. 2017 Mar 4;13(3):554-566.