Alfredo Sordelli Anette, Argentine microbiologist (Buenos Aires 28 January 1891 – 15 December 1967)
From Lombardian father
ACHIEVEMENTS
Demonstrated that agar and other carbohydrates can be antigens and stimulate precipitins
Demonstrated existence of a specific lipoid that fixates antibodies on heterogenetic antigen
His preparation and titration methods of bacterial toxins were adopted worldwide
Established titration methods of anti-diphtheria, anti-dysentery, anti-gangrene, anti-ophidic and other sera
Elaborated and perfected economic and rapid immunization for obtaining sera of high efficiency
Developed a technique for obtaining anti-diphtheria serum was later adopted by J. Bordet and perfected by Ramon
With A. Manzullo developed a method for diagnose of diphtheria
Developed methods for the preparation of insulin and other hormones such as estrogens and adrenaline
Imagined a method for isolating psittacosis virus
With Soriano, Ferrari & Torino described Clostridium saprotoxicum 1934
Discovered Clostridium sordellii, causative agent of gas gangrene (1922)
Created a method for measuring minute tensions
With R. Wernicke. Um metodo de medida de pequeñas tensiones. Anal. Asoc. Quim. Arg. 1:8, 1913
A new method for the preparation of serums on a large scale
Demonstrated that heteroantigen is composed of two parts (lipid and protein), a concept later retrieved by Landsteiner (1918-25)
With Deulofeu & Wernicke characterized Forssman antigen as a lipidic complex associated to a carrier protein
Naturaleza del antigeno heterogenetico. Rev. Asoc. Med. Arg. 37:570, 1924
Sur la nature de l’antigéne hétérogénétique. C.R. Soc. Biol. Paris 92:898, 1925
EPONYMY
Sordelli antitoxin (used against gas gangrene)
Sordelli technique for production of sera and vaccines anti gas gangrene
Sordelli method for preservation of microbial cultures by desiccation in vacuum
Sordelli-Miravent-Negroni culture medium (1926)
Sordelli-Deulofeu technique for preparation of insulin (1923)
Sordelli toxoid preparation technique
Sordelli-Miravent reaction for diagnosis of syphilis (1930)
Sordelli tubes