Yedy Israel Jacard, Chilean biochemist (Temuco 19 September 1939 –
Recognized as an international reference on gene therapy of alcoholism
Authored 208 papers, 34 book chapters and 12 books with 12,000 citations and 62H-index
SOME BIBLIOGRAPHY
With M.E. Quintanilla, L. Tampier, E. Karahanian, M. Rivera-Meza & M. Herrera Marschitz. Reward and relapse: complete gene-induced dissociation in an animal model of alcoholic dependence. Alcohol Clin. Exp. Res. 36:517-22, 2012
With P. Ocaranza, M.E. Quintanilla, L. Tampier, E. Karahanian & A. Sapag. Gene therapy reduces ethanol intake in an animal model of alcohol dependence. Clin. Exp. Res. 32:52-7, 2008
With M.E. Quintanilla, l. Tampier, A. Sapag & Z. Gerdzen. Sex differences, alcohol dehydrogenase, acetaldehyde burst and aversion to ethanol in the rat: a systems perspective. Am. J. Physiol. Endocrinol. Metab. 293:E351-7, 2007
With M.E. Quintanilla, A. Sapag & L. Tampier. The UChA and UChB rat lines; metabolic and genetic differences influencing ethanol intake. Addiction Bull. 11:310-23, 2006
With M.E. Quintanilla, L. Tampier & A. Sapag. Polymorphisms in the mitochondrial aldehyde dehydrogenase gene (Aldh2) determine peak blood acetaldehyde levels and voluntary ethanol consumption in rats. Pharmacogenet. Genomics 15:427-31, 2005
With M.E. Quintanilla, L. Tampier, A. Valle Prieto & A. Sapag. Complex I regulates mutant mitochondrial aldehyde dehydrogenase activity and voluntary ethanol consumption in rats. FASEB J. 19:36-42, 2005
Covalent binding of acetaldehyde to liver tubulin: a step in the right direction. Hepatology 9:161-2, 1989
With H. Orrego & O. Niemela. Immune responses to alcohol metabolites: pathogenic and diagnostic implications. Sem. Liver Dis. 8:81-90, 1988
With F.J. Carmichael, V. Saldivia, J. McKaigney & H. Orrego. Ethanol-induced increase in portal hepatic blood flow: interference by anesthetic agents. Hepatol. (Baltimore) 7:89-94, 1987
With E. Hurwitz, O. Niemela & R. Arnon. Monoclonal and polyclonal antibodies against acetaldehyde-containing epitopes in acetaldehyde-protein adducts. Proc. Natl. Acad. Sci. USA 83:7923-7, 1986
With S. Holt & H.A.Skinner. Early identification of alcohol abuse: clinical and laboratory indicators. Can. Med. Assoc. J. 124:1279-95, 1981
With H. Orrego. Hepatocyte demand and substrate supply as factors in the susceptibility to alcoholic liver injury: pathogenesis and prevention. Clin. Gastroenter. 10:355-73, 1981
With J. Talesnik & S. Belo. Enhancement of noradrenaline-induced metabolic coronary dilation by ethanol. Eur. J. Pharmacol. 61:279, 1980
With J.M. Khanna. Ethanol metabolism. Int. Rev. Physiol. 21:275-15, 1980
With J.M. Khanna, H. Orrego, G. Rachamin, S. Wahid, R. Britton, A. MacDonald & H. Kalant. Studies on metabolic tolerance to alcohol, hepatomegaly and alcoholic liver disease. Drug Alcohol Depend. 4:109,-18, 1979
With L. Videla, V. Fernandes-Vilela & J. Bernstein. Effects of chronic ethanol treatment and thyroxine administration on ethanol metabolism and liver oxidative capacity. J. Pharmacol. Exp. Ther. 192:565, 1975
With L. Videla, K.W. Flattery & E.A. Sellers. Ethanol metabolism and liver oxidative capacity in cold acclimation. J. Pharmacol. Exp. Ther. 192:575, 1975
With H. Kalant, H. Orrego, J.M. Khanna, L. Videla & J.M. Phillips. Experimental alcohol-induced hepatic necrosis: suppression by propylthiouracil. Proc. Natl. Acad. Sci. USA 72:1137-41, 1975
With L. Videla & J. Bernstein. Liver hypermetabolic state after chronic ethanol consumption: hormonal interrelations and pathogenic implications. Fed. Proc. 34:2052-9, 1975
With H. Seiden & H. Kalant. Activation of ethanol metabolism by 2,4-dinitrophenol in the isolated perfused rat liver. Biochem. Pharmacol. 23:2334, 1974
With J. Bernstein & l. Videla. Metabolic alterations produced in the liver by chronic ethanol administration. II. Changes related to energetic parameters of the cell. Biochem. J. 134:515, 1973
With D.B. Goldstein. Effects of ethanol on mouse brain (Na+K+) activated adenosine triphosphate. Life Sci. 2(2):957-63, 1972
Cellular effects of alcohol. A review. Quart. J. Stud. Alcohol 31:293-316, 1970
With L. Videla. Factors that modify the metabolism of ethanol in rat liver and adaptive changes produced by its chronic administration. Biochem. J. 118:275, 1970
With H. Kalant & M.A. Mahon. The effect of ethanol on acetylcholine synthesis, release and degradation in brain. Can. J. Physiol. Pharmacol. 45:172, 1967
With H. Kalant & A.E. LeBlanc. Effect of lower alcohols on potassium transport and microsomal adenosine triphosphatase activity of rat cerebral cortex. Biochem. J. 100:27-33, 1966
With H. Kalant. Effect of ethanol on electrolyte transport and electrogenesis in animal tissues. J. Cell. Comp. Physiol. 65:127, 1965
With H. Kalant. Effect of ethanol on the transport of sodium in the frog skin. Nature 200:476, 1963
PATENTS (6 patents for treatment of alcoholism-related products)
With M.E. Quintanilla Gonzalez, L. Tampier De Jong, A.D. Bustamante Cadiz, M. Herrera Marschitz & E. Karahanian Vartevanian. Expression vectors which inhibit synthesis of catalase and uses thereof (20120107923)
HONOURS
Jellinek Memorial Award in Alcoholism, Jellinek International Foundation (1980)
Distinguished Researcher Award, US Research Society on Alcoholism (1990)
Thurman Lectureship Award, Bowes Center for Alcohol Studies, University of, North Carolina (2006)
Ishii Memorial Award, International Society for Biomedical Research on Alcoholism (2014)
Lieber Lectureship Award, European Society for Biomedical Research on Alcoholism (2017)