Ji-sheng Han, Chinese neurophysiologist (Xiaoshan, Zhejiang Province 28 July 1928 –
Authored over 400 scientific papers
Discovered that serotonin (5-HT) and opioid peptides are the two main chemical substances mediating acupuncture analgesic effect
First to find the functional balance between opioid peptides and the anti-opioid peptides that determines the efficacy of acupuncture analgesia in different individuals
Discovered that the most important determination of acupuncture effect is the frequency of impulses transmitted along the nerve fibers from periphery to central nervous system
Invented Han’s acupoint nerve stimulator (HANS) used to treat neurological disorders and pain
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