Hector Croxatto Rezzio, Chilean biochemist (Valparaiso 03 July 1907 – Santiago 28 September 2010)
Authored over 300 works
His works on kalikrein-kynin system gained world acclaim
Discovered pepsanurin (1942) and PU-D1, a new kininogen-derived peptide
With R. Silva, X. Figueroa, R. Albertini, J. Roblero & M.P. Boric. A peptide released by pepsin from kininogen domain 1 is a potent blocker of AMP-mediated diuresis-natriuresis in the rat. Hypertension 30(4):897-904, 1997
Showed that the proteolytic hydrolysis of plasma proteins gave rise to potent peptides acting upon smooth muscles and kidney functions
With G.B. Marini-Bettolo purified and characterized renal proteins presenting important biological activity
Described a number of vasoactive peptides
With J. Masferrer, R. Albertini, P. Garcia & I. Pinto. Isolation and characterization of rat plasma glandular kallikrein. Biochem. Pharmacol. 34(1):51-6, 1985
Eponym of Porcelli-Croxatto method for studying urinary kallikrein (1970s)
Papers in top journals
With M. de la Lastra. Diurnal variations in ovarian ascorbic acid content of pseudopregnant immature rats used in Parlow’s test. Nature 208:789-90, 1965
With J. Arrau & H. Croxatto. Luteinizing hormone-like activity in human median eminence extracts. Nature 204:584-5, 1964
With M. de la Lastra. Ovarian ascorbic acid depleting activity in human brain extracts. Nature 204:583-4, 1964
With E. Labarca & G. Cofre. Effects od D,1-aldosterone on renal excretion of water, sodium, and potassium induced by renin. Nature 199:182-3, 1963
With J. Belmar. Hypertensive effects of bradykinin in rats. Nature 192:879-80, 1961
With T. Pereda & R. Mellada. Peptides with oxytocic and pressor activity obtained from acidified rat serum. Nature 184:1496, 1959
With F.B. Oberhauser, M.Q. Gaillard & M.V. Silva. Anti-tumorigenic action of iodinated compounds. Nature 176:466-7, 1955
With L. Barnafi. Anti-diuretic substances of the blood. Nature 172:304-5, 1953
With L. Barnafi, G. Rojas, A. Reyes & A. Infante. Anti-diuretic and oxytocic substances liberated by the digestion of plasmatic proteins with pepsin. Nature 171:82-3, 1953
With L. Barnafi & J. Passi. Effect of renin on diuresis in rats. Science 116 (3019):507-10, 1952
With G. Rojas & L. Barnafi. An antidiuretic substance obtained by digestion of globulin with pepsin. Science 113 (2939):494-5, 1951
With R. Croxatto & M. Reyes. The effect of hypertensin on the inactivation of oxytocin by the serum of pregnant women. Science 108 (2815):658-9, 1948
With R. Croxatto. Destruction of hypertensin and pepsitensin by an aminopeptidase obtained from yeast. Science 96 (2501):519-20, 1942
With R. Croxatto. Pepsitensin. A hypertension-like substance produced by peptic digestion of proteins. Science 95:1012, 1942
HONORS
Houssay Prize, OAS (1983)
LINKS
http://www.casinapioiv.va/content/accademia/en/academicians/deceased/croxatto.html