Otto Guilherme Bier, Brazilian bacteriologist and immunologist (Rio de Janeiro 26 March 1906 - São Paulo 22 November 1985)
From German descent
Authored over 100 works
ACHIEVEMENTS
Performed important contributions on studies of antigen-antibody reactions and complement system
With M. Siqueira found that antigen-antibody complexes can act even at the site of passive cutaneous anaphylaxis reactions evoked by unrelated antigen-antibody systems
Hemorrhagic reactions at sites of passive cutaneous anaphylaxis in guinea pig after intravenous inoculation of unrelated immune complex. Proceed. Soc. Exper. Biol. Med. 107(4):779-84, 1961
With M. Siqueira & G. Biozzi observed that immunological competence develops eventually, even in bursectomized animals, albeit with a considerable delay in time
Codescribed Pacheco disease in Psittacidade birds (1929)
Pacheco, G., Bier, O. Epizootie chex lês perroquets du Brésil. Relations avec Le psittacose. C.R. Séance Soc. Biol. 105:109-111, 1930.
Showed that Bothrops venom displayed inactivant action on fourth component of complement system
Uber Komplement-inativierung durch Bothropsgift (B. jararaca). Zeitschr. F. Immunit. 11:187-94, 1932
With M. Rocha e Silva noticed that the hemolysis is inhibited by hypertonic concentrations of NaCl (1935)
Demonstrated that role of histamine in the permeability of inflammation
With M.Rocha e Silva. Histamine as the primary cause of the increased capillary permeability in inflammation (1939)
Described serovar Salmonella butantan with Amaral, Peluffo & Biocca 1946
Described the biological role of antibodies on glomerulonephritis
With H.C. Passos, O.C. Martínez & M.S Pinheiro. Studies on the nephrotoxic activity of guinea-pig gamma 1 and gamma2 antibodies. Immun. 26(2):407-16, 1974
SOME OTHER IMPORTANT WORKS
With R. Binaghi, M. Akashi & E. Avelar Naves. Mechanism of anaphylactic desensitization in guinea pigs. Rev. Fr. Allergol. 9(4):246-50, 1969
With C. Stiffel, A. Perini, H.C. Passos & G. Biozzi. Role of the bursa of Fabricius and the thymus in the synthesis of opsonin type antibodies. Pathol. Biol. 16(1):67-72, 1968
With M. Rocha e Silva & M. Aronson. Histamine release by anaphylatoxin. Nature 168(4272):445-6, 1951
With N. Planet. Sur la presence d’un facteur qui augmente la permeabilité papillaire dans les extraits de peau normale. C.R. Soc. Biol. 129:65, 1938
METHODS
With M.S Pinheiro & R.S. Furlanetto. Amboceptor titration as a statistically controlled assay. J. Immunol. 69(3):241-6, 1952
With M.S Pinheiro & R.S. Furlanetto. Quantitative complement fixation in syphilis as a statistically controlled assay. J. Immunol. 74:51-6, 1954
With M.S Pinheiro, M.B. Esteves & P.M.Freire. Quantitative relations in complement fixation. Amer. J. Epidem. 89(3):353-7, 1969
With M.M. Mayer, A.G. Osier & M. Heidelberger. Quantitative studies of complement fixation. I. A method. J. Immunol. 59:195, 1948
With R. Furtado & E. Cisalpino. A plate technique for the conglutinative complement fixation test. Proc. Soc. Exptl. Biol. Med. 95:335-9, 1957.
With M. Siqueira & M.B. Esteves. Quantitative studies of complement fixation. I- A simplified and accurate procedure based on 50 per cent hemolytic end point. Rev. Inst. Med. Trop. São Paulo 10:199-208, 1968.
A simplified formula for the production of diphtheric toxin of high potency (50Lf). Rev. Bras. Biol. 3(3):325-9, 1943
Possibilidade de uma nova technica quantitativa da reação de Wassermann baseada na ação negativa dos componentes da alexina (1935)
With I. Mota, W. Dias da Silva and N. Vaz, published Imunologia Básica e Aplicada (Fundamentals of Immunology), translated into English and German languages (1973)
HONORS
Bieria Leão 1940 (Trematoda)