Hsiang-fu Kung, Chinese molecular geneticist (04 September 1942 – 17 June 2019)
Developed the first human interferon of world market (Hoffmann La Roche Inc.)
First to purify and crystallize recombinant human leukocyte interferon α A
First to prove the transforming activity of Ras protein and establish the roleof phospholipase C and nerve growth factor in Ras-mediated signal transduction pathways
Developed anti-cancer drug targeting on the activity of Ras farnesyl-protein transferase
Demonstrated the physiological roles of bone morphogenetic protein-4 (BMP-4) during embryonic development in Xenopus embryo
Elucidated the BMP4 signaling pathways and demonstrated the role of GATA-1 b protein in the inhibition of neurogenesis
Purified several anti-tumor and anti-viral agents from TCM and elucidated their mechanisms of action that were patented
Identified the active anti-HIV components in HCG preparations
Held many patents in United States of America
LINKS
https://www.lihs.cuhk.edu.hk/en-us/research/investigators/kunghsiangfu.aspx