Antonio Cechelli de Mattos Paiva, Brazilian biochemist (Mogi Mirim, São Paulo State 21 June 1929 – São Paulo 18 May 2006)
Authored about 150 papers
With his wife gained international recognition for their work on polypeptides syntheses
SYNTHESES OF PEPTIDES
With T.B. Paiva et al. New specific antagonists of angiotensin I and II (1973)
With T.B. Paiva & M.E. Miyamoto. An analogue peptide of pepsitensin (1973)
With T.B. Paiva & M.E. Miyamoto. Synthesis of a proposed pepsitensin. J. Med. Chem. 16(3):280, 1973
With M. Tominaga, J.M. Stewart & T.B. Paiva. New bradykinin potentiating peptides (1975)
With G. Goissis & V.L.A. Nouailhetas. Biologically active retroenantiomers of angiotensin peptides (1976)
With C.R. Nakaie, M.E.M. Oshiro & G. Goissis. New peptide analogues of angiotensin II (1977)
With E.B. Sabia, M. Tominaga & T.B. Paiva. New analogues of snake venom peptides (1978)
With C.R. Nakaie, E.G. Silva, E.M. Cilli, R. Marchetto, S. Schreier & T.B. Paiva. Synthesis and pharmacological properties of TOAC-labeled angiotensin and bradykinin analogs. Peptides 23(1):65-70, 2002
OTHER CONTRIBUTIONS
With T.B. Paiva & J.L. Prado demonstrated that angiotensin and pepsitensin were distinct substances
Non-identity between pepsitensin and hypertension revealed by paper electrophoresis. Science 120:611, 1954
With T.B. Paiva. The importance of the N-terminal of angiotensin II for its pressor and oxytocic activities. Biochem. Pharmacol. 5:181, 1960
With V.L.A. Nouailhetas, M.E. Miyamoto, G.B. Mendes & T.B. Paiva. New specific angiotensin inhibitors. J. Med. Chem. 16(1):6-9, 1973
With L. Oliveira & G. Vriend. A common step for signal transduction in G protein-coupled receptors. J. Comput. Aided Mol. Des. 7:649-58, 1993
A novel enzyme with activity tonin-like from rat submandibular gland (1993)
With N.L. Miasiro. Specific endothelin receptor agonists and antagonists disclose two new Etb receptors in the guinea pig ileum. Abst. XII Intern. Congr. Pharmacology p.572, 1994
With L. Oliveira & G. Vriend. A low resolution model for the interaction of G proteins with G-protein coupled receptors. Protein Engin. 12:1087-95, 1999
With M. Tominaga, S.R. Barbosa, S. Schreier, C.R. Nakaie et al. Fmoc-POAC: [(9-fluorenylmethyloxycarbonyl-2,2,5,5-tetramethylpyrrolidine-N-oxyl-3-amino-4-carboxylic acid]: A novel protected spin labeled amino acid for peptide and protein chemistry. Chem. Pharm. Bulletin 49(8):1027-9, 2001
With L. Oliveira, P.B. Paiva & G. Vriend. Sequence analysis reveals how G protein-coupled receptors transduce the signal to the G protein. Proteins 52:553-60, 2003
BRAZILIAN PATENTS
With C.R. Nakaie, M. Tominaga, S.R. Barbosa, R. Marchetto & S. Schreier. Síntese de um novo derivado de aminoacido paramagnético (epm-5) para uso em marcação de diferentes macromoléculas e sistemas de interesse químico-biológico PI9903137-0 A2 (1999)
With J.B. Pesquero, J.L. Pesquero, R.C. Araújo, M.A.S. Mori & M.S. Bader. Mecanismos e drogas utilizados no tratamento de diabetes, obesidade e controle dos distúrbios da fome (2005)
HONOURS
100 Best Scientists of the World, Banning Foundation, Cambridge, United Kingdom (2006)
His wife, Therezinha Bandiera de Paiva, pharmacologist (Paraguaçu Paulista, São Paulo State 20 April 1929 – São Paulo 15 March 2011)
From Italian descent
See above
BRAZILIAN PATENT
With E. Achar, A.H. Campos, W.S. Almeida, R.A.N. Achar & N. Schor. Uso da amitriptilina, composição, forma farmacêutica, produto alimentício e método para prevenção, tratamento e eliminação de cálculos renais em animais PI0400994-0 A2 (2004)
With E. Achar, A.H. Campos, W.S. Almeida, R.A.N. Achar & N. Schor. Uso da amitriptilina, composição, forma farmaceutica, produto alimentício e método para prevenção, tratamento e eliminação de cálculos renais em humanos PI0400995-9 A2 (2004)