Armando Santiago Parodi Trabucco, Argentine microbiologist and parasitologist (Haedo, Buenos Aires Province 06 May 1909 – 23 June 1969)
Isolated the Junín virus, causative agent of hemorrhagic Argentine fever
With D.J. Greenway, H.R. Rugiero, M. Frigerio, J.M. de la Barrera, N. Nettler, F. Garzón, M. Boxaca, L.B. Guerrero & N.R. Nota. Sobre la etiologia del brote epidémico de Junin. El Dia Medico 30:2000-10, 1958
Studied the characteristics of Junín virus
With C.E. Coto, M. Boxaca, S. Lajmanovich & S. Gonzalez. Characteristics of Junín virus. Arch. fur d. Ges. Virusforsch. 19(4):393-402, 1966
With M. Weissenbacher demonstrated that immune serum prevents death by Junín virus
Developed an attenuated strain of Junín virus
Isolated other causative agents
Aislamiento del agente causal de un síndrome de encefalo-papilitis. Rev. Soc. Arg. Biol. 30:53, 1954
With N.E. Mettler & C.A. Gianantonio. Aislamiento del agente causal del sindrome uremico-hemolítico. Medicina 23:139, 1963
Performed works on immunity in Chagas disease
HONORS
Medicine & Physiology Nobel prize nominee
His son, Armando José Antonio Parodi Lailame, biochemist (Buenos Aires 16 March 1942 -
Showed that the dolichol P-dependent pathway of protein N-glycosylation was present in mammalian and yeast (1975-8)
First description of the role of dolichol derivatives in the initial stages of protein N-glycosylation
Unravelled a basic metabolic pathway leading to the formation of glycoproteins and polysaccharides in mammals, plants fungi and protozoa (1981-3)
Showed that in members of the Trypanosomatidae family the pathway of N-linked oligosaccharide processing of protein is similar found that found in other eukaryotic cells
With L.A. Quesada Allué & J.J. Cazzulo. Pathway of the protein glycosilation in the trypanosomatid Crithidia fasciculata. Proc. Nat. Acad. Sci. 78:6021-5, 1981
Established its occurrence in the endoplasmic reticulum (1984)
Suggested the role of transient glycosylation in quality control og glycoprotein folding (2004-5)
RELEVANT PAPERS
With O.A. Castro & F. Movsichoff. Preferential transfer of the complete glycan is determined by the oligosaccharyltransferase complex and not by the catalytic subunit. Proceed. Nat. Acad. Sciences USA 103:14756-60, 2006
With N. Keith & J.J. Caramelo. Glycoprotein tertiary and quaternary structures are monitored by the same quality control mechanism. J. Biol. Chem. 280:18138-41, 2005
With J.J. Caramelo, O.A. Castro & G. Prat-Gay. The endoplasmic reticulum glucosyltransferase recognizes nerly native glycoprotein folding internmediates. J. Biol. Chem. 279:46280-5, 2004
With J.E. Ugalde & R.A. Ugalde. De novo synthesis of bacterial glycogen: Agrobacterium tumefaciens glycogen synthase is involved in glucan initiation and elongation. Proceed. Nat. Acad. Sciences USA 100:10659-63, 2003
With J.J. Caramelo, O.A. Castro, L.G. Alonso & G. Prat-Gay. UDP-Glc: glycoprotein glucosyltransferase recognizes structured and solvent accessible hydrophobic patches in molten-globule like folding intermediates. Proceed. Nat. Acad. Sciences USA 100:86-91, 2003
With C. Zuber, J.Y. Fan, B. Guhl, J.H. Fessler, C. Parker & J. Roth. Immunolocalization of UDP-Glc: glucoprotein glucosyltransferase indicates involvement of pre-Golgi intermediates in protein quality control. Proceed. Nat. Acad. Sciences USA 98:10710-5, 2001
With D.C. Tessier, D. Dignard, A. Zanpun, A. Radominska-Pandya, J.J.M. Bergeron & D.Y. Thomas. Cloning and characterization of mammalian UDP-glucose Glycoprotein Glycosyltransferase and the development of a specific substrate for the enzyme. Glycobiology 10:403-12, 2000
With M. Sousa. The molecular basis for the recognition of misfolded glycoproteins by the UDP-Glc: glycoprotein Glucosyltransferase. EMBO J. 14:4196-203, 1995
With V. Alvarez & R. Couso. Characterization of the mannose 6-phosphate dependent pathway of lysosomal enzyme routing in an invertebrate. Biochem. J. 310:589-95, 1995
With S. Merello & R.O. Couso. Characterization and partial purification of a novel enzymatic activity: UDP-GlcNAc Ser-protein N-acetylglucosamine-1-phosphotransferase from the cellular slime mold Dictyostelium discoideum. J. Biol. Chem. 270:7281-7, 1995
With S. Merello & M.T. Xavier. Novel Rhamnosyl and Ribosyl and uncommon (xylosyl) monosaccharide residues are present in asparagine-linked oligosaccharides of the trypanosomatid Blastocrithidia culicis. J. Biol. Chem. 269:20294-8, 1994
With S. Trombetta & M. Bosch. Glucosylation of glycoproteins by mammalian, plant, fungal and trypanosomatid protozoa microsomal membranes. Biochemistry 28:8108-16, 1989
With G.Z. Lederkremer. 3-0 methylation of mannose residues: a novel reaction in the processing of N-linked oligosaccharides occurring in Mucor rouxii. J. Biol. Chem. 259:12514-8, 1984
With D.H. Mendelzon & G.Z. Lederkremer. Transient glycosylation of protein-bound Man9GlcNAc2, Man8GlcNAc2 and Man7GlcNAc2 in calf thyroid cells: a possible recognition signal in the processing of glycoproteins. J. Biol. Chem. 258:8260-5, 1983
With L. Quesada Allué. Novel mannose carrier in the Trypanosomatid Crithidia fasciculata behaving as a short-saturated polyprenyl phosphate. Biochem. J. 212:123-8, 1983
With N.H. Behrens, L.F. Leloir & H. Carminatti. The role of polyprenyl-bound saccharides as intermediates in glycoprotein synthesis in liver. Proceed. Nat. Acad. Sciences USA 69:3268-72, 1972
With N.H. Behrens & L.F. Leloir. Glucose transfer from dolichol monophosphate glucose. The product formed with endogenous microsomal acceptor. Proceed. Nat. Acad. Sciences USA 68:2857-60, 1971
HONOURS
International Research Scholar, Howard Hughes Medical Institute (1997-2011)
Karl Meyer Award in Glycobiology, American Society for Glycobiology (2011)