Ivan da Mota e Albuquerque, Brazilian immunologist (Recife 09 October 1920 – São Paulo 25 September 2014)
Authored at least 132 papers
ACHIEVEMENTS
Demonstrated that granulations of mast cells store histamine
With L.C.U. Junqueira, W.T. Beraldo & R.G. Ferri. Intracellular distribution of histamine. Nature 174:698-9, 1954
With L.C.U. Junqueira, W.T. Beraldo & A.G. Ferri. Action of peptone on mastcells of the dog. Nature 173:547, 1954
Possibly the first demonstration of apparent abundance of RNA in retinal cones and rods
With M.Rabinovitch & S. Yoneda. Note on the histochemical localization of glycogen and pentose polynucleotides in the visual cells of the chick (Gallus gallus). Quart. J. Micr. Science 95(1):5, 1954
Described antigen-induced mast cell degranulation in vitro (1956) and in vivo
With I. Vugman. Effect of anaphylactic shock and compound 48-80 on the mast cells of the guinea-pig lung. Nature 177:427-9, 1956
Concluded that mast cells have antibodies fixed on them
With W. Dias da Silva. Antigen-induced damage to isolated sensitized cells. Nature 186:245-6, 1960
With W. Dias da Silva demonstrated that in low concentration of anti-histamine substances inhibit their release by mast cells and in high concentration occur the inverse (1960)
With W. Dias da Silva showed that anaphylactic antibodies perform reactions only after binding to surface receptors on mast cells
Discovered IgE antibodies before Ishizaka
Suggested the existence of mast cell sensitizing antibody
Mast cell lytic antibodies. Nature 192:1201, 1961
Characterized the mast cell sensitizing antibody
Biological characterization of mast cell sensitizing antibodies. Life sciences 1:465-74, 1963
First obtained the induction of an antibody able to sensitize mast cells
The mechanism of anaphylaxis. I. Production and biological properties of mast cell sensitizing antibodies. Immunol. 7:681-99, 1963
With J.M. Peixoto. A skin-sensitizing and thermolabile antibody in the mouse. Life Sciences 5:1723-5, 1966
Demonstrated mast cells role in anaphylaxis and other IgE-dependent phenomena
First to identify the biological activity and properties of IgE and IgG1 antibodies
Obtained a new rattle snake antivenin serum (1999)
With O. Bier, W. Dias da Silva & N. Vaz, authored Imunologia Básica e Aplicada (Fundamentals of Immunology), translated to English and German (1973)
METHODS
A method for quantitative estimation of mast cells in the bone marrow of the rat. Blood 6:81, 1951
With S. Yoneda & I. Rabinovich. Plasmal reaction in the blood and haemopoietic organs. Proc. Soc. exper. Biol. Med. 81:338, 1952
Developed Braga-Mota method
With F. Braga. Homologous passive cutaneous anaphylaxis (PCA) in mice and heterologous PCA induced in rats with mouse IgE. Immunol. 30:655-57, 1976
With I. Fernandes, F. Gourmont, D. Latinne et al. A rapid and efficient purification method for horse IgG(T) using a rat monoclonal antibody. Braz. J. Med. Biol. Research 27:2599-06, 1994
HONOURS
Visiting Professor, Department of Medicine, School of Medicine, Georgetown University, United States
Honorary Research Assistant, University College of London (1957-8)