Eduardo Hernán Charreau, Argentine molecular endocrinologist (San Fernando, Buenos Aires Province 27 May 1940 – Buenos Aires 23 March 2019)
Authored over 200 works
Discovered novel metabolic pathways in normal and pathologic tissues
First to describe some molecular insulin and prolactin induced mechanisms about steroid metabolism of Leydig and luteal cells and in accessory sexual glands
Characterized the receptor for luteinizing hormone and prolactin in Leydig cells
Discovered that ovary resistance syndrome is due to circulating antibodies that affect the follicle stimulating hormone
Developed and characterized a prostagen induced mammary carcinogenesis model
Demonstrated that prostagens can reproduce their proliferative effects through 4 molecular families regulation such as insulin like factors, heregulin, tyrosine kinase type I activity receptors and growth factors type beta
First to report interaction between progestin and the signal transduction pathways HRG/ErbB in mammary cancer (1999)
Explained the molecular failures of the reproductive system in experimental diabetes
Performed molecular characterization of the growth promoting effects of progestin hormones on mammary carcinogenesis
Showed the activity of juvenile hormone analogues on steroid biosynthesis