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Primary Hemostasis
Primary Hemostasis
Platelets ↓
Thrombopoietin ↓
Bone marrow function ↓
Splenomegaly
Nutritional deficiency
VWF function ↑
VWF antigen and activity ↑↑
Large VWF multimers ↑
ADAMTS13 ↓
Secondary Hemostasis
Secondary Hemostasis
Procoagulants ↓
Factors I, II, V,VII, IX, X, XI, XIII
Anticoagulants ↓
Procoagulant ↑
Antithrombin ↓
Protein C ↓
Protein S ↓
Factor VIII ↑↑↑
Fibrinolytic System
Fibrinolytic System
Plasminogen ↓
Alpha-2 antiplasmin ↓
TPA ↑
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