Established cerebrovascular event (excluding TIA within previous 2 months)
Active bleeding diathesis
Recent gastrointestinal bleeding (within previous 10 days)
Neurosurgery (intracranial, spinal) within previous 3 months
Intracranial trauma within previous 3 months
Cardiopulmonary resuscitation within previous 10 days
Major nonvascular surgery or trauma within previous 10 days
Uncontrolled hypertension (systolic >180 mmHg or diastolic >110 mmHg)
Puncture of noncompressible vessel
Intracranial tumor
Recent eye surgery
Hepatic failure, particularly those with coagulopathy
Bacterial endocarditis
Pregnancy
Active diabetic proliferative retinopathy