After a procedure, the goal is to restart anticoagulation as quickly as possible. The timing of anticoagulation after a procedure depends mainly on procedural bleeding risk and bleeding-related complications. Typically, the person who performed the procedure is best equipped to decide when anticoagulation can be restarted. In patients who are considered to be at high risk for thrombotic events, but in whom procedure-related bleeding risk is perceived to be high, alternatives to full-dose anticoagulation with long-acting agents should be considered.