Patents
The Rush To Market
The race is on!
Approximately 10 organizations along with NIH grants (taxpayer monies) have paid for these find-a-cure studies. Six patents have been applied for to date by Johns Hopkins and Stanford University.
Stanford University
Article
Drug Des Devel Ther. 2016; 10: 1307–1322.
Published online 2016 Apr 1. doi: 10.2147/DDDT.S101486
PMCID: PMC4827596
PMID: 27103785
Identification of new drug candidates against Borrelia burgdorferiusing high-throughput screening
Venkata Raveendra Pothineni,1 Dhananjay Wagh,1 Mustafeez Mujtaba Babar,1Mohammed Inayathullah,1 David Solow-Cordero,2 Kwang-Min Kim,1 Aneesh V Samineni,1Mansi B Parekh,1 Lobat Tayebi,3 and Jayakumar Rajadas1
1Biomaterials and Advanced Drug Delivery Laboratory, Stanford Cardiovascular Pharmacology Division, Cardiovascular Institute, Stanford University School of Medicine, Palo Alto, CA, USA
2Chemical & Systems Biology, Stanford University School of Medicine, Stanford, CA, USA
3Department of Developmental Sciences, Marquette University School of Dentistry, Milwaukee, WI, USA
Correspondence: Jayakumar Rajadas, Biomaterials and Advanced Drug Delivery Laboratory, Stanford Cardiovascular Pharmacology Division, Cardiovascular Institute, Stanford University School of Medicine, 1050 Arastradero Road, Building A, Room A148, Palo Alto, CA 94304, USA, Tel +1 650 724 6806, Fax +1 650 724 4694, Email ude.drofnats@ajaryaj
Link To Article
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827596/
Funding
Bay Area Lyme Foundation
Patent
Johns Hopkins
Articles
1. Activity of Sulfa Drugs and Their Combinations against Stationary Phase B. burgdorferi In Vitro.
Feng J, Zhang S, Shi W, Zhang Y.
Antibiotics (Basel). 2017 Mar 22;6(1). pii: E10. doi: 10.3390/antibiotics6010010.
PMID: 28327498
Select item 272427572.
Feng J, Shi W, Zhang S, Sullivan D, Auwaerter PG, Zhang Y.
Front Microbiol. 2016 May 23;7:743. doi: 10.3389/fmicb.2016.00743. eCollection 2016.
PMID: 27242757
Select item 260387473.
Feng J, Wang T, Shi W, Zhang S, Sullivan D, Auwaerter PG, Zhang Y.
Emerg Microbes Infect. 2014 Jul;3(7):e49. doi: 10.1038/emi.2014.53. Epub 2014 Jul 2.
PMID: 26038747
Select item 258068114.
Feng J, Auwaerter PG, Zhang Y.
PLoS One. 2015 Mar 25;10(3):e0117207. doi: 10.1371/journal.pone.0117207. eCollection 2015.
PMID: 25806811
Select item 270256315.
Feng J, Weitner M, Shi W, Zhang S, Sullivan D, Zhang Y.
Antibiotics (Basel). 2015 Sep 16;4(3):397-410. doi: 10.3390/antibiotics4030397.
PMID: 27025631
Select item 269548816.
Feng J, Shi W, Zhang S, Zhang Y.
Emerg Microbes Infect. 2015 Jun 3;4:e31. doi: 10.1038/emi.2015.31.
PMID: 26954881
Funding
1. Steven & Alexandra Cohen Foundation, the Global Lyme Alliance, the Lyme Disease Association, and NatCapLyme. We thank Richard Horowitz for suggesting some drug combinations tested in this study. Ying Zhang was supported in part by NIH grants AI099512 and AI108535.
2. We acknowledge the support of our work by Global Lyme Alliance, Johns Hopkins Fisher Center for Environmental Infectious Diseases, and Steven & Alexandra Cohen Foundation. We also thank Lyme Disease Association, NatCapLyme, Steve Sim, and Jonathan Locke for their support. YZ was supported in part by NIH grants AI099512 and AI108535.
3. We thank Lyme Research Alliance and LymeDisease.org for support of this work.
4. Lyme Research Alliance (Tick Borne Disease Alliance) http://www.lymeresearchalliance.org/ The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
5. This work was supported by the Global Lyme Alliance (formerly Lyme Research Alliance). Y.Z. was supported in part by Global Lyme Alliance and NIH grants AI099512 and AI108535.
6. We thank the NCI Developmental Therapeutic Program/NIH for providing the NCI compound library collection. This work was supported by the Global Lyme Alliance (formerly Lyme Research Alliance). Ying Zhang was supported in part by Global Lyme Alliance and NIH grant numbers AI099512 and AI108535.
Patents
Elevated ccl19 after completion of therapy for acute lyme disease identifies …
John N. Aucott The Johns Hopkins University
Priority 2015-04-16 • Filed 2016-04-18 • Published 2016-10-20
All human subject studies in this manuscript were reviewed and approved by the Johns Hopkins School of Medicine Institutional Review Board (protocol … The present invention relates to the field of Lyme disease. More specifically, the present invention provides methods and composition useful for the …
Elevated CCL19 after completion of therapy for acute lyme disease identifies …
John N. Aucott The Johns Hopkins University
Filed 2018-08-08 • Granted 2019-11-19 • Published 2019-11-19
All human subject studies in this manuscript were reviewed and approved by the Johns Hopkins School of Medicine Institutional Review Board (protocol … The present invention relates to the field of Lyme disease. More specifically, the present invention provides methods and composition useful for the …
Identification of additional anti-persister activity against borrelia …
WO US US20190008848A1
Ying Zhang The Johns Hopkins University
Priority 2015-08-21 • Filed 2016-08-19 • Published 2019-01-10
… . Baltimore: Johns Hopkins University Press, 1998 (12th edition) or the more recent online database: Online Mendelian Inheritance in Man, OMIM™. … further comprising treating Lyme disease in a patient in need thereof, the method comprising administering to a patient an effective amount of at …
Compositions and methods for diagnosing and treating lyme disease
WO US US20180246095A1
Ying Zhang The Johns Hopkins University
Priority 2015-08-19 • Filed 2016-08-17 • Published 2018-08-30
The present invention relates to compositions and methods of diagnosing and treating Lyme disease.
Identification of novel anti-persister activity for borrelia burgdorferi
WO EP CN EP3149190A1
Ying Zhang The Johns Hopkins University
Priority 2014-05-09 • Filed 2015-04-02 • Published 2017-04-05
… stored at -20 °C. Each drug in the Johns Hopkins Clinical Compound Library (JHCCL) (Chong et al, 2006) was made into 10-mM stock solutions with DMSO. … 91. The method of claim 82, wherein the subject has, or is suspected of having, post-treatment Lyme disease syndrome (PTLDS) and/or antibiotic …
Assays for detection of acute lyme disease
Last Updated November 2019
Lucy Barnes
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