List of Antibiotics Found More Effective

Part 1- In the past few years a series of studies have been done in labs (not on humans yet) that gives us an idea of what the best drugs are for treating/killing ALL forms of Lyme disease.

Their work continues to built on the work of others before them, including Dr. Alan MacDonald, Eva Sapi, Ph.D., Brorson & Brorson and some additional well respected researchers.

These latest authors tested a long list of FDA approved drugs already on the market that included some currently used for treating cancer and other diseases. They also performed studies on various essential oils, spices, etc. to find out which ones, if any, might be effective in killing various forms of the Lyme bacteria.

The series of studies mentioned above can be found below under the heading Part 1 Studies. If you click the title you can read the abstract and/or full study linked there.

Part 2- Some of the antibiotics that tested successfully in the lab (Part 1 Studies) were then combined and used by a long-time treating doctor in clinical studies of Lyme patients. Those studies can be found below under the heading Part 2 Studies.

I share this information for several reasons that also come with a warning.

Part 1 studies were performed in a lab and not used in humans. More work needs to be done before successful protocols can be established.

Part 2 studies were only recently performed by a very experienced doctor using humans as test subjects. More work needs to be done before the kinks can be worked out.

The main reason I shared this information is to let those who are suffering know that there is hope and we are finally moving towards finding a cure.

Part 1 Studies

Stationary phase persister/biofilm microcolony of Borrelia burgdorferi causes more severe disease in a mouse model of Lyme arthritis: implications for understanding persistence, Post-treatment Lyme Disease Syndrome (PTLDS), and treatment failure.

Feng J, Li T, Yee R, Yuan Y, Bai C, Cai M, Shi W, Embers M, Brayton C, Saeki H, Gabrielson K, Zhang Y.

Discov Med. 2019 Mar;27(148):125-138.

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Identification of Essential Oils with Strong Activity against Stationary Phase Borrelia burgdorferi.

Feng J, Shi W, Miklossy J, Tauxe GM, McMeniman CJ, Zhang Y.

Antibiotics (Basel). 2018 Oct 16;7(4). pii: E89. doi: 10.3390/antibiotics7040089.

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Selective Essential Oils from Spice or Culinary Herbs Have High Activity against Stationary Phase and Biofilm Borrelia burgdorferi.

Feng J, Zhang S, Shi W, Zubcevik N, Miklossy J, Zhang Y.

Front Med (Lausanne). 2017 Oct 11;4:169. doi: 10.3389/fmed.2017.00169. eCollection 2017.

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Activity of Sulfa Drugs and Their Combinations against Stationary Phase B. burgdorferi In Vitro.

Feng J, Zhang S, Shi W, Zhang Y.

Antibiotics (Basel). 2017 Mar 22;6(1). pii: E10. doi: 10.3390/antibiotics6010010.

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Ceftriaxone Pulse Dosing Fails to Eradicate Biofilm-Like Microcolony B. burgdorferiPersisters Which Are Sterilized by Daptomycin/ Doxycycline/Cefuroxime without Pulse Dosing.

Feng J, Zhang S, Shi W, Zhang Y.

Front Microbiol. 2016 Nov 4;7:1744. eCollection 2016.

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A Drug Combination Screen Identifies Drugs Active against Amoxicillin-Induced Round Bodies of In Vitro Borrelia burgdorferi Persisters from an FDA Drug Library.

Feng J, Shi W, Zhang S, Sullivan D, Auwaerter PG, Zhang Y.

Front Microbiol. 2016 May 23;7:743. doi: 10.3389/fmicb.2016.00743. eCollection 2016.

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Eradication of Biofilm-Like Microcolony Structures of Borrelia burgdorferi by Daunomycin and Daptomycin but not Mitomycin C in Combination with Doxycycline and Cefuroxime.

Feng J, Weitner M, Shi W, Zhang S, Zhang Y.

Front Microbiol. 2016 Feb 10;7:62. doi: 10.3389/fmicb.2016.00062. eCollection 2016.

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Persister mechanisms in Borrelia burgdorferi: implications for improved intervention.

Feng J, Shi W, Zhang S, Zhang Y.

Emerg Microbes Infect. 2015 Aug;4(8):e51. doi: 10.1038/emi.2015.51. Epub 2015 Aug 19. No abstract available. Erratum in: Emerg Microbes Infect. 2015;4:e56.

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Identification of novel activity against Borrelia burgdorferi persisters using an FDA approved drug library.

Feng J, Wang T, Shi W, Zhang S, Sullivan D, Auwaerter PG, Zhang Y.

Emerg Microbes Infect. 2014 Jul;3(7):e49. doi: 10.1038/emi.2014.53. Epub 2014 Jul 2.

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Drug combinations against Borrelia burgdorferi persisters in vitro: eradication achieved by using daptomycin, cefoperazone and doxycycline.

Feng J, Auwaerter PG, Zhang Y.

PLoS One. 2015 Mar 25;10(3):e0117207. doi: 10.1371/journal.pone.0117207. eCollection 2015.

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Identification of Additional Anti-Persister Activity against Borrelia burgdorferi from an FDA Drug Library.

Feng J, Weitner M, Shi W, Zhang S, Sullivan D, Zhang Y.

Antibiotics (Basel). 2015 Sep 16;4(3):397-410. doi: 10.3390/antibiotics4030397.

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Identification of new compounds with high activity against stationary phase Borrelia burgdorferi from the NCI compound collection.

Feng J, Shi W, Zhang S, Zhang Y.

Emerg Microbes Infect. 2015 Jun 3;4:e31. doi: 10.1038/emi.2015.31.

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An optimized SYBR Green I/PI assay for rapid viability assessment and antibiotic susceptibility testing for Borrelia burgdorferi.

Feng J, Wang T, Zhang S, Shi W, Zhang Y.

PLoS One. 2014 Nov 3;9(11):e111809. doi: 10.1371/journal.pone.0111809. eCollection 2014.

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Economic impact of Lyme disease.

Zhang X, Meltzer MI, Peña CA, Hopkins AB, Wroth L, Fix AD.

Emerg Infect Dis. 2006 Apr;12(4):653-60.

Part 2 Studies

Precision medicine: retrospective chart review and data analysis of 200 patients on dapsone combination therapy for chronic Lyme disease/post-treatment Lyme disease syndrome: part 1.

Horowitz RI, Freeman PR.

Int J Gen Med. 2019 Feb 18;12:101-119. doi: 10.2147/IJGM.S193608. eCollection 2019.

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Precision Medicine: The Role of the MSIDS Model in Defining, Diagnosing, and Treating Chronic Lyme Disease/Post Treatment Lyme Disease Syndrome and Other Chronic Illness: Part 2.

Horowitz RI, Freeman PR.

Healthcare (Basel). 2018 Nov 5;6(4). pii: E129. doi: 10.3390/healthcare6040129.

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IMPORTANT

We Also Know, As We've Said All Along, The Lyme Treatment Recommended By the Infectious Diseases Society of America (IDSA) Was NOT Able To Cure Many Cases Of Lyme Disease.