The A320 fleet was inherited from the merger with US Airways in 2015. Currently there are 48 in the fleet with plans to retire older A320s. The legacy USAir fleet is powered by the CFM56-5B3/P engines and are EOW certified. The legacy America West fleet is powered by the IAE V2533-A5 engines. Both types use wing tip fences. 

All A320s are equipped with Gogo's 2Ku satellite Wi-Fi and IFE onboard is free to stream on your personal device. There are 12 First Class seats, 18 Main Cabin Extra, and 120 Main Cabin seats.

On March 4, 2024, American Airlines announced it will retrofit the A319 and A320 fleets with an enhanced cabin featuring more premium seats. The first aircraft tot get the retrofit will be the 32 a319s in late 2025