Masters Applied Projects

Project 31

Analysis of PPODA-QT Hydrogel Cast to Restrict Fusiform Aneurysm


Student:
Bhavya Sharma

Mentors:
Dr. Brent Vernon, PhD - Arizona State University, SBHSE
Dr. Rosalind Sadleir, PhD - Arizona State University, SBHSE
Dr. Tyler Cole, MD - Barrow Neurological Institute

YouTube Link:
View the video link below before joining the zoom meeting

Zoom Link:
https://asu.zoom.us/j/85943287103


Abstract
Intracranial fusiform aneurysms are rare in comparison to saccular aneurysms, and have limited effective treatment strategies. PPODA-QT hydrogels have previously been used in the embolization of saccular aneurysms with promising results. Due to the different morphology of a fusiform aneurysm, we have utilized PPODA-QT as a cast to restrict the aneurysm instead. We hypothesize that encapsulating the aneurysm using a cast made out of hydrophobic fabric and PPODA-QT will prevent the aneurysm from dilating further. In order for the cast to be suitable for surgical application, gelation should occur within 20 minutes. Therefore, we will first analyze the impact of temperature, pH, and mixing time in the gelation, and degradation and swelling time of the gel in accelerated conditions. Then, to determine the impact of the cast on the hemodynamic profile of the aneurysm, we will perform finite element analysis in COMSOL. We will also assess the adherence of the hydrophobic fabric and hydrogel to the hydrophilic blood vessel surface. The results from this study will help us understand the efficacy of a unique restriction mechanism to prevent aneurysm rupture.