Masters Applied Projects

Project 19

Neural Analysis of Electrophysiological Recordings from Patients with Essential Tremor Using a Chronic Sensing Neurostimulator

Student:
Grace Lowor

Mentors:

Dr. Bradley Greger, PhD – Arizona State University, SBHSE
Dr. Jit Muthuswamy, PhD – Arizona State University, SBHSE
Dr. Marco Santello, PhD – Arizona State University, SBHSE

YouTube Link:
View the video link below before joining the zoom meeting

Zoom Link:
https://asu.zoom.us/j/86819387835


Abstract
Essential Tremor (ET) is a common neurological disorder endemic to a growing population that presents itself as a classic hand/postural tremor. Deep brain stimulation (DBS) has been shown to provide symptomatic relief to patients with essential tremor refractory to standard medical interventions. The present study aims to analyze postoperative electrophysiological recordings from the anatomical regions of ET patients implanted with DBS electrodes. In this research study, we will record electrophysiological data in a stimulation OFF state while subjects complete simple fine and gross motor tasks. We will perform spectral analysis of local field potential (LFP) recordings to identify potential biomarkers that are specific to the underlying neurologic condition. We will also utilize statistical analysis to measure the statistical significance and clinical relevance of the findings of this study. The results of this study will provide an insight into the neurophysiology underlying essential tremor movements and further contribute to evidence-based practices.