Team 19
Improvement of Balloon Atrial Septostomy for Patients Born with Transposition of the Great Arteries
Team Members:
Lauren Baker
Kayla Charles
Ronin Komarnisky
Haley Strauss
Brycelyn Whitman
Team Mentors:
Improvement of Balloon Atrial Septostomy for Patients Born with Transposition of the Great Arteries
Team Members:
Lauren Baker
Kayla Charles
Ronin Komarnisky
Haley Strauss
Brycelyn Whitman
Team Mentors:
Ms. Sara Belko - Thomas Jefferson University Medical College
Dr. Mehdi Nikkhah, PhD - Arizona State University, SBHSE
YouTube Link:
View the video link below before joining the zoom meeting
Zoom Link:
https://asu.zoom.us/j/86453522335
Abstract
Transposition of the great arteries (TGA) is a congenital birth defect in which the aorta and pulmonary arteries are switched resulting in oxygenated blood delivered to the lungs and deoxygenated blood delivered to the body which results in cyanosis. It affects 4.7 children in every 10,000 born with diagnosis done prenatally or within the first few hours of life. Currently, balloon atrial septostomy (BAS) is a quick, temporary solution for the lack of oxygen saturation in infants born with TGA. In this procedure, the foramen ovale between the atria is enlarged with a balloon catheter. A trained pediatric cardiologist inserts the catheter into the femoral artery where it is pushed up to the heart through the foramen ovale. The balloon(s) are inflated using saline solution, and the catheter with the inflated balloons is pulled through the hole, enlarging it. The process is repeated until the hole is large enough (4-8mm) to allow the deoxygenated and oxygenated blood to mix for sufficient oxygen delivery. Through interviewing key users, the Hole Hearts’ team determined that the current devices used are too large with size 6Fr (1Fr ≈ 0.33mm) with low visibility due to an unmarked tip. Additionally, the procedure often needs to be repeated for an adequately sized foramen ovale. To meet the unmet need, Hole Hearts’ has developed the HH-4 atrioseptostomy catheter that lowers the balloon catheter’s size to a 4Fr catheter with a 5Fr sheath, three spherical balloons (diameters 9.5mm, 11.5mm, and 13.5mm), and a radiopaque tip with markings at every 20mm with an estimated cost of $1,200, competitive with current BAS catheters. The Hole Hearts’ HH-4 atrioseptostomy catheter facilitates one time use to ensure optimal expansion of the foramen ovale with a low profile to minimize risk of adverse events compared to competitors.
