Masters Applied Projects

Project 25

Ligand-Receptor Mediated Interactions between Glioblastoma Tumor Cells and Glioma-Associated Microglia and Macrophages at Single Cell Resolution to Promote Proliferation and Invasion

Student:
Adrienne Parkinson

Mentors:

Dr. Benjamin Bartelle, PhD – Arizona State University, SBHSE
Dr. Christopher Plaisier, PhD – Arizona State University, SBHSE
Dr. Nhan Tran, PhD – Mayo Clinic

YouTube Link:
View the video link below before joining the zoom meeting

Zoom Link:
https://asu.zoom.us/j/6200576443


Abstract:
Glioblastoma (GBM) tumor cells thrive in the presence of many resident and infiltrating cell types including microglia. Identifying interactions between these supporting immune cells and GBM tumor cells is vital for understanding how tumors invade and proliferate in the brain. Here, we analyze RNA sequencing data from four isocitrate dehydrogenase (IDH) wild-type primary glioblastoma tissue samples at single-cell resolution and compare their transcriptome to ten controls from epileptic patients to identify glioma associated transcriptomic changes in microglia. Data from this study will be used in future studies to identify receptor-ligand pairs and prioritize those that likely affect hallmarks of cancer.