Masters Applied Projects

Project 18

Neuroinflammation Following Peripheral Immunomodulatory Therapeutics for TBI


Student:
Nazira Kwanda

Mentors:

Dr. Acharya Abhinav, PhD - Arizona State University, SEMTE
Dr. Sarah E. Stabenfeldt, PhD - Arizona State University, SBHSE
Dr. Kuei-Chun (Mark) Wang, PhD - Arizona State University, SBHSE

YouTube Link:
View the video link below before joining the zoom meeting

Zoom Link:
https://asu.zoom.us/j/85906197009


Abstract
Neuroinflammation associated with TBI may lead to secondary injury causing cell death and reduced regenerative capacity in the brain. Re-establishing immune homoeostasis by the metabolic reprogramming of central nervous system infiltrating T-cells activated during neuroinflammation will induce anti-inflammatory mediation and facilitate recovery post-TBI. We hypothesize that “subcutaneous injections of formulations delivering metabolic pathway inhibitors and an antigen will decrease effector T cell (T_EFF) populations in vivo, increase antigen-specific regulatory T-cells (T_REG), and prevent TBI progression”. This study assesses the immune cells activated and lesions in CCI TBI mouse model. Results from this study will help understand the efficacy of our immunomodulatory therapeutic for tissue regeneration and inflammation prevention post-TBI.