Key Area 3
(d) One gene, many proteins
Our genome is large - but our proteome is larger - how? In this section, we will explore the idea that one gene forms many proteins through a process known as alternative RNA splicing. You should complete the "Something to Read" section and then choose at least 1 other task to complement your at-home learning.
Something to Read...
Open the document below and read the mandatory course notes provided by SQA for this Key Area. You may wish to use your home learning time to copy these notes into a jotter or choose a digital presentation format that suits your learning style.
Something to Watch...
Here are a couple of short videos on mRNA splicing. The Oxford University one contains too much detail but I think it is excellent to give you more depth of understanding.
Something to look at...
Here is an image of alternative RNA splicing. Gene X is shown at the top, comprised of 5 introns and 4 exons - this is the primary mRNA transcript. Depending on the exons that are included in the mature transcript following RNA splicing, it is hypothesised that protein Y or protein Z could be produced. Note that the ORDER of exons remains the same (you can't combine 3,2,1 for instance). In this way, 2 proteins have been created from the same gene.
You are now ready for your in-class lesson on alternative RNA splicing. Remember to bring any questions or queries with you.
Click here if you are ready to move onto Formation of Polypeptides.
