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Computational Drug Discovery | Bioactive Compound | Microbial Pigment
Computational Drug Discovery | Bioactive Compound | Microbial Pigment
Tanjilur Rahman, Mohammed Sajjad Hossain Bappi,Tanim Jabid Hossain*
Summary: Dengue virus (DENV) and Zika virus (ZIKV), members of the Flaviviridae family transmitted by Aedes mosquitoes, continue to pose significant global public health challenges. Despite extensive research, effective treatments for these viruses remain elusive, highlighting the urgent need for new and efficient antiviral therapies. This study explores prodigiosin, a microbial tripyrrole pigment, as a potential antiviral agent against DENV and ZIKV through comprehensive computational analyses. Prodigiosin exhibited favorable drug-likeness properties, meeting Lipinski's rule of five and demonstrating optimal physicochemical and pharmacokinetic characteristics according to Ghose's, Veber's, Egan’s and Muegge's filters, essential for oral bioavailability. ADMET profiling further revealed high intestinal absorption, minimal risk for drug-drug interactions, and a low toxicity profile, with no observed AMES toxicity, hepatotoxicity, or skin sensitization. Molecular docking studies showed prodigiosin’s strong binding affinities to the NS5 methyltransferases of both viruses, suggesting disruption of the viral replication process. Notably, prodigiosin's binding affinities were comparable to those of chloroquine and ribavirin 5'-triphosphate, known inhibitors of ZIKV and DENV, respectively. Molecular dynamics simulations further supported these findings, demonstrating stable and specific interactions between prodigiosin and NS5 MTases, with low root mean square deviation values. Additional analyses, including root mean square fluctuation, radius of gyration, and solvent-accessible surface area, confirmed the compactness and stability of the complexes. These promising results suggest that prodigiosin could serve as a broad-spectrum antiviral agent, warranting further experimental validation and continued investigation for therapeutic development against flaviviral infections.
Traditional Fermented Beverages| Probiotic Benefits
Traditional Fermented Beverages| Probiotic Benefits
Tanim Jabid Hossain*, Md. Sajib Khan, Jannatul Ferdouse
Summary: Fermented and dairy beverages, enriched with probiotics, stand as integral components of Bangladesh's culinary heritage. This article explores the diverse landscape of these beverages, emphasizing their significance as potential reservoirs of probiotic lactic acid bacteria. From the iconic fermented beverage date palm sap to an array of dairy staples like milk, borhani, and laban, each beverage presents a unique microbial profile. Studies isolating strains within these drinks underscore their probiotic potential, exhibiting multifaceted benefits such as antimicrobial efficacy, antioxidant capabilities, a cholesterol-lowering effect, and exopolysaccharide production. In vitro probiotic assessments further unveil the strains' ability to withstand gastric conditions and colonize the gastrointestinal tract. The exploration extends to genomic dimensions, unraveling the genetic basis of promising probiotic strains and offering insights into their mechanisms of action. This includes the identification of genes encoding key bioactive metabolites, antimicrobial peptides, nutraceuticals, and flavor compounds. Importantly, while this research is rooted in the context of Bangladesh's culinary heritage, the implications of probiotic lactic acid bacteria extend globally, enriching our understanding of probiotics' impact on health, offering potential benefits to populations worldwide. However, this burgeoning field faces certain limitations, necessitating further research to bridge gaps in understanding the exact mechanisms for probiotic functionalities, specific health effects, and unexplored probiotic properties. The intricate interplay between the beverages and lactic acid bacteria opens avenues for innovative applications beyond tradition, leveraging the full potential of these probiotic-rich beverages for functional food development, health-focused interventions, and potentially advantageous contributions to food preservation. Importantly, while this research is rooted in Bangladesh's culinary tradition, the implications of probiotics extend globally, enriching our understanding of their health benefits and potentially influencing wellness worldwide.
Environmental Engineering | Bioremediation
Environmental Engineering | Bioremediation
Biosurfactant-Producing Bacteria: Key Insights into Isolation, Characterization, Production, and Applications in Environmental Remediation and Microbial Enhanced Oil Recovery (MEOR)
Biosurfactant-Producing Bacteria: Key Insights into Isolation, Characterization, Production, and Applications in Environmental Remediation and Microbial Enhanced Oil Recovery (MEOR)
Tanim Jabid Hossain*, Md. Sajib Khan
Summary: Biosurfactants, amphiphilic molecules produced by diverse microorganisms, play a pivotal role in environmental remediation and microbial enhanced oil recovery (MEOR) due to their unique properties. These molecules are identified through rigorous screening processes following the isolation and characterization of biosurfactant-producing bacteria from various environments, including soil, marine habitats, extreme environments, industrial settings, and oil reservoir. Methods such as drop collapse test, oil displacement method, surface tension measurement, emulsification assay, hemolysis assay, and Thin layer chromatography (TLC) are commonly employed to determine the biosurfactant producing capacity of these strains. For industrial applications, scaling up production often requires optimizing culture conditions, bioprocess engineering, and fermentation parameters. In environmental bioremediation, biosurfactants enhance the biodegradation of hydrophobic pollutants, facilitating the cleanup of oil-contaminated soils and waters. Their ability to solubilize and emulsify hydrocarbons makes them effective in mitigating the environmental impacts of oil spills and industrial effluents. Additionally, biosurfactants are significant in MEOR strategies as they improve oil recovery efficiency by reducing interfacial tension, altering wettability, and mobilizing trapped oil fractions in reservoirs. Their biodegradability, low toxicity, and robustness in harsh conditions make them sustainable alternatives to chemical surfactants in petroleum extraction processes. In addition, biosurfactants have diverse applications across multiple sectors, including their use as biopesticides and soil conditioners in agriculture, emulsifiers in the food industry, and drug delivery systems and skincare formulations in healthcare. This review synthesizes recent advancements in biosurfactant research, emphasizing their diverse habitats, screening strategies, production, and applications in sustainable environmental remediation and MEOR. Future research should explore biosurfactant producing strains having high efficacy and innovative applications of biosurfactants to address evolving environmental and industrial challenges.
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