Genomics and Bioinformatics

Genomics

The most important of our isolates needs to be comprehensively characterized for the full exploitation of their useful properties which can be achieved by their genome analysis. The genome analysis of microbes can provide a comprehensive view of their genetic makeup and evolutionary history. It helps in identifying their genes responsible for various functions such as metabolism, virulence, antibiotic resistance, and symbiosis. Therefore, in order to have a detailed understanding of our microbes at the genetic level, we have their whole genome sequenced followed by an extensive genome-mining leading towards identification of the genes of probiotic and industrial importance. 

Bioinformatics

To uncover the diversity and distribution of metabolically important genes and proteins across bacterial and fungal species, we perform sequence analysis, looking for key sequence features. This approach is essential for investigating the function, structure, and evolution of proteins. With the continued development of sequencing technologies and bioinformatics tools, sequence analysis of proteins and enzymes can play a critical role in understanding the molecular biology and biochemistry of microbes and other organisms. 

Additionally, we analyze bioactive molecules to understand their mechanisms, targets, and interactions with these targets using in silico methods, including molecular dynamics studies. These approaches allow us to explore the dynamic behavior of biomolecular systems, providing insights into the structure-function relationships and aiding in the development of new therapeutic strategies. 

Research Projects:

Research Outline

Bioactive Molecules for Beneficial Applications

Maximizing Health with Probiotics

Bioenriched Functional Foods

Probiotics for Plant Health

Biological Pollution Control

Management of Phytopathogens

One Health Approach to Zoonones

Ecology and Diversity

Genomics and Bioinformatics