Research Vision:

Our research focuses on deciphering the mechanisms of how cancers evade the antitumor immune response. Our goal is to develop novel colorectal cancer therapies designed to increase the number of tumor-infiltrating T cells. Our approach aims to boost the effectiveness of existing immune checkpoint inhibitors to improve patients' survival outcomes.

Research Areas:

• Colorectal cancer

• Tumor immunology and immunotherapy

• Gut microbiome

Research Publications:

1. Zhao X, Yuan C, Wangmo D, Subramanian S. Tumor secreted extracellular vesicles regulate T-cell costimulation and can be manipulated to induce tumor-specific T-cell responses. Gastroenterology 2021Aug;161(2):560-574.e11. doi: 10.1053/j.gastro.2021.04.036

2. Zhao X, Kassaye B, Wangmo D, Lou E, Subramanian S. Chemotherapy but Not the Tumor Draining Lymph Nodes Determine the Immunotherapy Response in Secondary Tumors. iScience 2020 23(5):101056

3. Yuan C, Graham M, Subramanian S. Mucosal Microbiota and Metabolome along the Intestinal Tract Reveal a Location-Specific Relationship. mSystems 2020 5(3):e00055-20

4. Nair, AA Tang X, Thompson KJ, Kalari KR, Subramanian S. MicroRNA response elements frequency identifies dysregulation of MAPK signaling in triple negative breast cancer. doi: http://dx.doi.org/10.1101/817098. iScience 2020 23(6):101249

5. Yuan C, Burns M, Subramanian S*, Blekhman R*. Interaction between host microRNAs and the gut microbiota in colorectal cancer. mSystems 2018 15: 3 e00205-17.