Research Vision:
The Saltzman lab is one of the nation's leading labs studying microbial-based immunotherapy for cancer. This lab studies the use of microbes that colonize the tumor microenvironment to act as a "smart bomb" to deliver immune-modulating proteins directly to the tumor microenvironment.
Research Areas:
Microbial-based immunotherapy
Immunomodulating proteins
Cancer modeling
Research Publications:
Forbes NS, Coffin RS, Deng L, Evgin L, Fiering S, Giacalone M, Gravekamp C, Gulley JL, Gunn H, Hoffman RM, Kaur B, Liu K, Lyerly HK, Marciscano AE, Moradian E, Ruppel S, Saltzman DA, Tattersall PJ, Thorne S, Vile RG, Zhang HH, Zhou S, McFadden G. White paper on microbial anti-cancer therapy and prevention. J Immunother Cancer. 2018 Aug 6;6(1):78. doi: 10.1186/s40425-018-0381-3. PMID: 30081947; PMCID: PMC6091193.
Saltzman D, Augustin L, Leonard A, Mertensotto M, Schottel J. Low dose chemotherapy combined with attenuated Salmonella decreases tumor burden and is less toxic than high dose chemotherapy in an autochthonous murine model of breast cancer. Surgery. 2018 Mar;163(3):509-514. doi: 10.1016/j.surg.2017.09.036. Epub 2017 Dec 8. PMID: 29229318.
Drees JJ, Augustin LB, Mertensotto MJ, Schottel JL, Leonard AS, Saltzman DA. Soluble production of a biologically active single-chain antibody against murine PD-L1 in Escherichia coli. Protein Expr Purif. 2014 Feb;94:60-6. doi: 10.1016/j.pep.2013.10.023. Epub 2013 Nov 8. PMID: 24215864.
Drees J, Mertensotto M, Liu G, Panyam J, Leonard A, Augustin L, Schottel J, Saltzman D. Attenuated Salmonella enterica Typhimurium reduces tumor burden in an autochthonous breast cancer model. Anticancer Res. 2015 Feb;35(2):843-9. PMID: 25667465.
Drees JJ, Mertensotto MJ, Augustin LB, Schottel JL, Saltzman DA. Vasculature Disruption Enhances Bacterial Targeting of Autochthonous Tumors. J Cancer. 2015 Jul 15;6(9):843-8. doi: 10.7150/jca.12491. PMID: 26284135; PMCID: PMC4532981.