Research Areas:

• Vascular-level approach to sepsis, hemorrhage, and volume overload

• Large animal modeling and physiology

• Device design

Research Vision:

Our interdisciplinary and multi-institutional research group believes synergy between surgeons, anesthesiologists, basic scientists, and engineers is vital to address major clinical challenges. Using techniques such as large animal modeling, rational device design, and artificial intelligence, we are characterizing a novel animal model of septic shock, and harnessing information from transduced venous waveforms to estimate intravascular volume.

Research Publications:

1. Wise ES, Hocking KM, Polcz ME, Beilman GJ, Brophy CM, Sobey JH, Leisy PJ, Kiberenge RK, Alvis BD. Hemodynamic Parameters in the Assessment of Fluid Status in a Porcine Hemorrhage and Resuscitation Model. Anesthesiology. 2021 Apr 1;134(4):607-616. doi: 10.1097/ALN.0000000000003724. PMID: 33635950; PMCID: PMC7946734.

2. Wise ES, Hocking KM, Eagle S, Absi T, Komalavilas P, Cheung-Flynn J, Brophy CM. Preservation solution impacts physiologic function and cellular viability of human saphenous vein graft. Surgery. 2015 Aug;158(2):537-46. doi: 10.1016/j.surg.2015.03.036. Epub 2015 May 21. PMID: 26003912; PMCID: PMC4492846.

3. Wise ES, Hocking KM, Evans BC, Duvall CL, Cheung-Flynn J, Brophy CM. Unregulated saphenous vein graft distension decreases tissue viscoelasticity. Perfusion. 2017 Sep;32(6):489-494. doi: 10.1177/0267659117697814. Epub 2017 Mar 9. PMID: 28820033; PMCID: PMC5967241.

4. Alvis BD, McCallister R, Polcz M, Lima JLO, Sobey JH, Brophy DR, Miles M, Brophy C, Hocking K. Non-Invasive Venous waveform Analysis (NIVA) for monitoring blood loss in human blood donors and validation in a porcine hemorrhage model. J Clin Anesth. 2020 May;61:109664. doi: 10.1016/j.jclinane.2019.109664. Epub 2019 Nov 28. PMID: 31786067; PMCID: PMC8171001.

5. Wise ES, Wergin JE, Mace EH, Kallos JA, Muhlestein WE, Shelburne NJ, Hocking KM, Brophy CM, Guzman RJ. Upper Extremity Pulse Pressure Predicts Amputation-Free Survival after Lower Extremity Bypass. Am Surg. 2017 Jul 1;83(7):804-811. PMID: 28738956.