Research Vision:

My research program aims to understand the alterations in myocardial bioenergetics following chronic cardiac ischemia and revascularization in an effort to target adjunctive therapies that will provide more complete recovery following CABG.

Research Areas:

• Hibernating myocardium

• Surgical revascularization

• Mitochondrial basis of cardiac ischemia

Research Publications:

1. Chen Q, Qi S, Hocum-Stone L, Lesnefsky E, Kelly RF, McFalls EO. Preventing Myocardial Injury Following Non-Cardiac Surgery: A Potential Role for Preoperative Antioxidant Therapy with Ubiquinone. Antioxidants (Basel). 2021 Feb 10;10(2):276. doi: 10.3390/antiox10020276. PMID: 33579045; PMCID: PMC7916807.

2. Hocum Stone LL, Swingen C, Wright C, Qi SS, Rassette M, McFalls EO, Kelly RF. Recovery of hibernating myocardium using stem cell patch with coronary bypass surgery. J Thorac Cardiovasc Surg. 2021 Jul;162(1):e3-e16. doi: 10.1016/j.jtcvs.2019.12.073. Epub 2020 Jan 11. PMID: 32059928.

3. Hocum Stone L, Chappuis E, Wright C, Kelly RF, McFalls EO. CoQ₁₀ enhances PGC1α and increases expression of mitochondrial antioxidant proteins in chronically ischemic swine myocardium. Nutr Metab (Lond). 2019 Dec 30;16:92. doi: 10.1186/s12986-019-0418-8. PMID: 31892934; PMCID: PMC6937679.

4. Hocum Stone L, Wright C, Chappuis E, Messer M, Ward HB, McFalls EO, Kelly RF. Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery. J Vis Exp. 2018 Mar 27;(133):57229. doi: 10.3791/57229. PMID: 29658941; PMCID: PMC5933266.

5. Hocum Stone LL, Swingen C, Holley C, Wright C, Chappuis E, Ward HB, McFalls EO, Kelly RF. Magnetic resonance imaging assessment of cardiac function in a swine model of hibernating myocardium 3 months following bypass surgery. J Thorac Cardiovasc Surg. 2017 Mar;153(3):582-590. doi: 10.1016/j.jtcvs.2016.10.089. Epub 2016 Nov 16. PMID: 27939502.