Research Vision:

The mechanisms of lung transplant allograft rejection are unclear, and because of this knowledge gap, survival after lung transplant is limited.

Research Areas:

• Activation of graft antigen-specific recipient lymphocytes after lung transplant

• Antigen presentation in lung transplant rejection

• Lung transplant outcomes

Research Publications:

1. Aggarwal R, Jackson S, Lemke NT, Shumway SJ, Kelly RF, Hertz M, Huddleston SJ. Lung Transplant Recipients With Prior Coronary Artery Bypass Grafting Are at Increased Risk of Death and Early Perioperative Hemorrhage. Semin Thorac Cardiovasc Surg. 2021 May 21:S1043-0679(21)00244-6. doi: 10.1053/j.semtcvs.2021.03.048. Epub ahead of print. PMID: 34023526.

2. Huddleston SJ, Jackson S, Kane K, Lemke N, Shaffer AW, Soule M, Hertz M, Shumway S, Qi S, Perry T, Kelly R. Separate Effect of Perioperative Recombinant Human Factor VIIa Administration and Packed Red Blood Cell Transfusions on Midterm Survival in Lung Transplantation Recipients. J Cardiothorac Vasc Anesth. 2020 Nov;34(11):3013-3020. doi: 10.1053/j.jvca.2020.05.038. Epub 2020 Jun 3. PMID: 32718888.

3. Huddleston SJ, Brown R, Rudser K, Goswami U, Tomic R, Lemke NT, Shaffer AW, Soule M, Hertz M, Shumway S, Kelly R, Loor G. Need for tracheostomy after lung transplant predicts decreased mid- and long-term survival. Clin Transplant. 2020 Jan;34(1):e13766. doi: 10.1111/ctr.13766. Epub 2019 Dec 31. PMID: 31815320.

4. Loor G, Warnecke G, Villavicencio MA, Smith MA, Kukreja J, Ardehali A, Hartwig M, Daneshmand MA, Hertz MI, Huddleston S, Haverich A, Madsen JC, Van Raemdonck D. Portable normothermic ex-vivo lung perfusion, ventilation, and functional assessment with the Organ Care System on donor lung use for transplantation from extended-criteria donors (EXPAND): a single-arm, pivotal trial. Lancet Respir Med. 2019 Nov;7(11):975-984. doi: 10.1016/S2213-2600(19)30200-0. Epub 2019 Aug 1. PMID: 31378427.

5. Elde S, Huddleston S, Jackson S, Kelly R, Shumway S, Loor G. Tailored Approach to Surgical Exposure Reduces Surgical Site Complications after Bilateral Lung Transplantation. Surg Infect (Larchmt). 2017 Nov/Dec;18(8):929-935. doi: 10.1089/sur.2017.144. Epub 2017 Oct 20. PMID: 29053438.