Research Vision:

Development of neuromodulation therapies for the treatment of cardiometabolic diseases such as hypertension, diabetes, and obesity.

Research Areas:

• Interaction of renal nerves and renal inflammation in hypertension

• Autonomic neuromodulation

• Neurogenic mechanisms of cardiovascular disease

Research Publications:

1. Banek CT, Knuepfer MM, Foss JD, Fiege JK, Asirvatham-Jeyaraj N, Van Helden D, Shimizu Y, Osborn JW. Resting Afferent Renal Nerve Discharge and Renal Inflammation: Elucidating the Role of Afferent and Efferent Renal Nerves in Deoxycorticosterone Acetate Salt Hypertension. Hypertension. 2016 Dec;68(6):1415-1423. doi: 10.1161/HYPERTENSIONAHA.116.07850. Epub 2016 Oct 3. PMID: 27698066; PMCID: PMC5159336.

2. Banek CT, Gauthier MM, Van Helden DA, Fink GD, Osborn JW. Renal Inflammation in DOCA-Salt Hypertension. Hypertension. 2019 May;73(5):1079-1086. doi: 10.1161/HYPERTENSIONAHA.119.12762. PMID: 30879356; PMCID: PMC6540804.

3. Osborn JW, Foss JD. Renal Nerves and Long-Term Control of Arterial Pressure. Compr Physiol. 2017 Mar 16;7(2):263-320. doi: 10.1002/cphy.c150047. PMID: 28333375.

4. Asirvatham-Jeyaraj N, Gauthier MM, Banek CT, Ramesh A, Garver H, Fink GD, Osborn JW. Renal Denervation and Celiac Ganglionectomy Decrease Mean Arterial Pressure Similarly in Genetically Hypertensive Schlager (BPH/2J) Mice. Hypertension. 2021 Feb;77(2):519-528. doi: 10.1161/HYPERTENSIONAHA.119.14069. Epub 2021 Jan 4. PMID: 33390041; PMCID: PMC7803455.

5. Osborn JW, Tyshynsky R, Vulchanova L. Function of Renal Nerves in Kidney Physiology and Pathophysiology. Annu Rev Physiol. 2021 Feb 10;83:429-450. doi: 10.1146/annurev-physiol-031620-091656. PMID: 33566672.