Research Vision:

Our lab group investigates the role of the microbiome in outcomes following colorectal surgery. We aim to improve outcomes by reestablishing healthy gut flora.

Research Areas:

• Intestinal microbiome

• Anastomotic leaks

• Surgical site infections

Research Publications:

1. Jahansouz C, Staley C, Kizy S, Xu H, Hertzel AV, Coryell J, Singroy S, Hamilton M, DuRand M, Bernlohr DA, Sadowsky MJ, Khoruts A, Ikramuddin S. Antibiotic-induced Disruption of Intestinal Microbiota Contributes to Failure of Vertical Sleeve Gastrectomy. Ann Surg. 2019 Jun;269(6):1092-1100. doi: 10.1097/SLA.0000000000002729. PMID: 31082907.

2. Jahansouz C, Staley C, Bernlohr DA, Sadowsky MJ, Khoruts A, Ikramuddin S. Sleeve gastrectomy drives persistent shifts in the gut microbiome. Surg Obes Relat Dis. 2017 Jun;13(6):916-924. doi: 10.1016/j.soard.2017.01.003. Epub 2017 Jan 4. PMID: 28279578.

3. Jahansouz C, Xu H, Hertzel AV, Serrot FJ, Kvalheim N, Cole A, Abraham A, Luthra G, Ewing K, Leslie DB, Bernlohr DA, Ikramuddin S. Bile Acids Increase Independently From Hypocaloric Restriction After Bariatric Surgery. Ann Surg. 2016 Dec;264(6):1022-1028. doi: 10.1097/SLA.0000000000001552. PMID: 26655924.

4. Nalluri H, Kizy S, Ewing K, Luthra G, Leslie DB, Bernlohr DA, Sadowsky MJ, Ikramuddin S, Khoruts A, Staley C, Jahansouz C. Peri-operative antibiotics acutely and significantly impact intestinal microbiota following bariatric surgery. Sci Rep. 2020 Nov 23;10(1):20340. doi: 10.1038/s41598-020-77285-7. PMID: 33230230; PMCID: PMC7684314.

5. Jahansouz C, Xu H, Hertzel AV, Kizy S, Steen KA, Foncea R, Serrot FJ, Kvalheim N, Luthra G, Ewing K, Leslie DB, Ikramuddin S, Bernlohr DA. Partitioning of adipose lipid metabolism by altered expression and function of PPAR isoforms after bariatric surgery. Int J Obes (Lond). 2018 Feb;42(2):139-146. doi: 10.1038/ijo.2017.197. Epub 2017 Aug 14. Erratum in: Int J Obes (Lond). 2019 Sep;43(9):1880-1881. PMID: 28894292; PMCID: PMC5803459.