Research Vision:

The goal of my research is to identify the mechanisms involved in the initiation and progression of salt-sensitive hypertension. Current studies are focused on the events involved in the initiation of renal inflammation.

Research Areas:

• Blood pressure control

• Salt-sensitivity

• Renal function

Research Publications:

1. Evans LC, Petrova G, Kurth T, Yang C, Bukowy JD, Mattson DL, Cowley AW Jr. Increased Perfusion Pressure Drives Renal T-Cell Infiltration in the Dahl Salt-Sensitive Rat. Hypertension. 2017 Sep;70(3):543-551. doi: 10.1161/HYPERTENSIONAHA.117.09208. Epub 2017 Jul 10. PMID: 28696224; PMCID: PMC5589123.

2. Evans LC, Dayton A, Yang C, Liu P, Kurth T, Ahn KW, Komas S, Stingo FC, Laud PW, Vannucci M, Liang M, Cowley AW Jr. Transcriptomic analysis reveals inflammatory and metabolic pathways that are regulated by renal perfusion pressure in the outer medulla of Dahl-S rats. Physiol Genomics. 2018 Jun 1;50(6):440-447. doi: 10.1152/physiolgenomics.00034.2018. Epub 2018 Mar 30. PMID: 29602296; PMCID: PMC6032288.

3. Evans LC, Ryan RP, Broadway E, Skelton MM, Kurth T, Cowley AW Jr. Null mutation of the nicotinamide adenine dinucleotide phosphate-oxidase subunit p67phox protects the Dahl-S rat from salt-induced reductions in medullary blood flow and glomerular filtration rate. Hypertension. 2015 Mar;65(3):561-8. doi: 10.1161/HYPERTENSIONAHA.114.04468. Epub 2014 Dec 8. PMID: 25489057; PMCID: PMC4326559.

4. Evans LC, Ivy JR, Wyrwoll C, McNairn JA, Menzies RI, Christensen TH, Al-Dujaili EA, Kenyon CJ, Mullins JJ, Seckl JR, Holmes MC, Bailey MA. Conditional Deletion of Hsd11b2 in the Brain Causes Salt Appetite and Hypertension. Circulation. 2016 Apr 5;133(14):1360-70. doi: 10.1161/CIRCULATIONAHA.115.019341. Epub 2016 Mar 7. PMID: 26951843; PMCID: PMC4819772.

5. Palygin O, Evans LC, Cowley AW Jr, Staruschenko A. Acute In Vivo Analysis of ATP Release in Rat Kidneys in Response to Changes of Renal Perfusion Pressure. J Am Heart Assoc. 2017 Sep 12;6(9):e006658. doi: 10.1161/JAHA.117.006658. PMID: 28899893; PMCID: PMC5634305.