Fertility Effects Of Grewia tenax Methanolic Root Extract On Female Wistar Rats
Fertility Effects Of Grewia tenax Methanolic Root Extract On Female Wistar Rats
Peter J. Kasyoki1*, Catherine K. Kaingu2, Christine O. Wangia3, Faraj O. Alkizim4
1 Department of Medical Physiology, Jomo Kenyatta University of Agriculture and Technology, P.O Box
62000-00200, Nairobi Kenya
2 Department of Veterinary Anatomy and Physiology, University of Nairobi, P.O Box 30197-00100,
Nairobi, Kenya
3 Department of Pharmacology, Jomo Kenyatta University of Agriculture and Technology, P.O Box 62000-00200, Nairobi Kenya
4 Department of Human Anatomy, Jomo Kenyatta University of Agriculture and Technology, P.O Box 62000-00200, Nairobi Kenya
Article history:
Received: 29 July, 2021
Accepted: 28 September, 2021
Available Online: 11 March, 2022
Corresponding Author:
Peter J. Kasyoki
Peter J. Kasyoki, Catherine K. Kaingu, Christine O. Wangia, Faraj O. Alkizim are awarded with Marie Curie Research Award- 2022 in Medical Physiology
Abstract
Globally, infertility is estimated to be 8-12 percent of couples within the childbearing years, while in Kenya it is at 11.9 per cent. In ethnobotanical studies in Kenya and India, Grewia tenax, a shrub (Fam. Teliaceae), has been reported to be used as a pro-fertility herb. The objective of the current study was to determine the effects of Grewia tenax root methanol extract on fertility. The plants’ effect on estrus cycle and reproductive hormones in female wistar albino rats was evaluated. The extract significantly regularized disrupted estrus cycle compared to the negative control. The plant extract also caused increased reproductive hormone levels compared to the negative control. The plant extract has fertility enhancing potential. The plant species requires further research to establish its mechanism of action and its effect on reproductive hormone receptors to aid towards development of novel infertility treatment drug.
Keywords:
Pro-fertility, Grewia tenax, Estrus cyclicity, Reproductive hormones
Citation:
Peter J. Kasyoki, Catherine K. Kaingu, Christine O. Wangia, Faraj O. Alkizim, 2022. Fertility Effects Of Grewia tenax Methanolic Root Extract On Female Wistar Rats. International Journal of Medicinal Plants. Photon 116, 992-1001
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