The Lancet Infectious Diseases, Early Online Publication, 10 May 2013

doi:10.1016/S1473-3099(13)70085-9Cite or Link Using DOI

Lyme disease vaccination: are we ready to try again?

Paul M Lantos a

Borrelia burgdorferi —the spirochete that causes Lyme disease—was first identified in 1981. By 1983, it was known that most patients with Lyme disease have antibodies to a 31 kD protein that would come to be known as outer surface protein A (OspA). 1 Antibodies against OspA were shown to protect laboratory animals against experimental infection with B burgdorferi . 2 Research in the 1990s 3 , 4 ultimately confirmed the suitability of OspA vaccination for prevention of human Lyme disease. Two commercial Osp ...

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