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The Lancet Infectious Diseases, Early Online Publication, 10 May 2013
Borrelia burgdorferi —the spirochete that causes Lyme disease—was first identified in 1981. By 1983, it was known that most patients with Lyme disease have antibodies to a 31 kD protein that would come to be known as outer surface protein A (OspA). 1 Antibodies against OspA were shown to protect laboratory animals against experimental infection with B burgdorferi . 2 Research in the 1990s 3 , 4 ultimately confirmed the suitability of OspA vaccination for prevention of human Lyme disease. Two commercial Osp ...
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