Reference
Cytochrome P450 HomepageNelson, DR (2009) The Cytochrome P450 Homepage. Human Genomics 4, 59-65.AlphafoldJohn Jumper, Richard Evans, Alexander Pritzel, et al. - Highly accurate protein structure prediction with AlphaFold. Nature, 1–11, doi: 10.1038/s41586-021-03819-2 (2021)ColabfoldMirdita M, Ovchinnikov S and Steinegger M. ColabFold - Making protein folding accessible to all. bioRxiv, doi: 10.1101/2021.08.15.456425 (2021)Localcolabfoldhttps://github.com/YoshitakaMo/localcolabfoldReference
Cytochrome P450 HomepageComprehensive Bacterial P450shttps://drnelson.uthsc.edu/comprehensive-bacterial-p450s/
Method
Localcolabfold (model1_ptm, recycle=6 or CaRMSD < 0.4, centerd and rotated around proximal Cys)runner_P450align.py -f CYPs/CYPXXXA1.fasta -nm 5 -mr 6 -alirunner_P450align.py -f CYPs/CYPXXXA1.fasta -nm 5 -mr 6 -ali -upMaestro (Protein preparation Wizard)proPKa pH 7.0, save as pdbHeme was extract from proximal-ligand-aligned crystal structure of CYP101A1-CYP150A1Heme was added hydrogen using maestro builder, save as mol2ES_scoreMaestro output AlphaFold2_advanced.ipynb (for the preparation of movie)Method
CYP71
>CYP71A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ---- MAILVSLLFL AIALTFFLLK LNEKREKKPN LPPSPPNLPI IGNLHQLGNL PHRSLRSLAN ELGPLILLHL GHIPTLIVST AEIAEEILKT HDLIFASRPS TTAARRIFYD CTDVAFSPYG EYWRQVRKIC VLELLSIKRV NSYRSIREEE VGLMMERISQ SCSTGEAVNL SELLLLLSSG TITRVAFGKK YEGEEERKNK FADLATELTT LMGAFFVGDY FPSFAWVDVL TGMDARLKRN HGELDAFVDH VIDDHLLSRK ANGSDGVEQK DLVDVLLHLQ KDSSLGVHLN RNNLKAVILD MFSGGTDTTA VTLEWAMAEL IKHPDVMEKA QQEVRRVVGK KAKVEEEDLH QLHYLKLIIK ETLRLHPVAP LLVPRESTRD VVIRGYHIPA KTRVFINAWA IGRDPKSWEN AEEFLPERFV NNSVDFKGQD FQLIPFGAGR RGCPGIAFGI SSVEISLANL LYWFNWELPG DLTKEDLDMS EAVGITVHMK FPLQLVAKRH LSCYP71
Colabfold_advanced outputs
Colabfold_advanced outputs
CYP72
>CYP72A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 --- MEMDMDTIRK AIAATIFALV MAWAWRVLDW AWFTPKRIEK RLRQQGFRGN PYRFLVGDVK ESGKMHQEAL SKPMEFNNDI VPRLMPHINH TINTYGRNSF TWMGRIPRIH VMEPELIKEV LTHSSKYQKN FDVHNPLVKF LLTGVGSFEG AKWSKHRRII SPAFTLEKLK SMLPAFAICY HDMLTKWEKI AEKQGSHEVD IFPTFDVLTS DVISKVAFGS TYEEGGKIFR LLKELMDLTI DCMRDVYIPG WSYLPTKRNK RMKEINKEIT DMLRFIINKR MKALKAGEPG EDDLLGVLLE SNIQEIQKQG NKKDGGMSIN DVIEECKLFY FAGQETTGVL LTWTTILLSK HPEWQERARE EVLQAFGKNK PEFERLNHLK YVSMILYEVL RLYPPVIDLT KIVHKDTKLG SYTIPAGTQV MLPTVMLHRE KSIWGEDAME FNPMRFVDGV ANATKNNVTY LPFSWGPRVC LGQNFALLQA KLGLAMILQR FKFDVAPSYV HAPFTILTVQ PQFGSHVIYK KLESCYP72
CYP73
>CYP73A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ---- MDLLLIEKTL VALFAAIIGA ILISKLRGKK FKLPPGPIPV PIFGNWLQVG DDLNHRNLTD LAKRFGEILL LRMGQRNLVV VSSPELAKEV LHTQGVEFGS RTRNVVFDIF TGKGQDMVFT VYGEHWRKMR RIMTVPFFTN KVVQQYRYGW EAEAAAVVDD VKKNPAAATE GIVIRRRLQL MMYNNMFRIM FDRRFESEDD PLFLKLKALN GERSRLAQSF EYNYGDFIPI LRPFLRNYLK LCKEVKDKRI QLFKDYFVDE RKKIGSTKKM DNNQLKCAID HILEAKEKGE INEDNVLYIV ENINVAAIET TLWSIEWGIA ELVNHPEIQA KLRHELDTKL GPGVQITEPD VQNLPYLQAV VKETLRLRMA IPLLVPHMNL HDAKLGGFDI PAESKILVNA WWLANNPDQW KKPEEFRPER FLEEEAKVEA NGNDFRYLPF GVGRRSCPGI ILALPILGIT IGRLVQNFEL LPPPGQSKID TDEKGGQFSL HILKHSTIVA KPRSFCYP73
CYP74 (Not Monooxygenase)
>CYP74A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ---- MATAAACISF ASPSPARVVI RRQTRASASA SATDRQEVVS PKRRLPLRKV PGDYGPPVVG AIRDRYEYFY GPGGRDGFFA ARVRAHRSTV VRLNMPPGPF VARDPRVVAL LDAASFPVLF DTSLVDKTDL FTGTFMPSTD LTGGYRVLSY LDPSEPNHAP LKTLLFYLLS HRRQQVIPKF REVYGDLFGL MENDLARVGK ADFGVHNDAA AFGFLCQGLL GRDPAKSALG RDGPKLITKW VLFQLSPLLS LGLPTLVEDT LLHSLRLPPA LVKKDYDRLA DFFRDAAKAV VDEGERLGIA REEAVHNILF ALCFNSFGGM KILFPTLVKW LGRAGARVHG RLATEVRGAV RDNGGEVTMK ALAEMPLVKS AVYEALRIEP PVAMQYGRAK RDMVVESHDY GYEVREGEML FGYQPMATKD PRVFARPEEY VPDRFLGEDG ARLLRHVVWS NGPETAAPTL HDKQCAGKDF VVLVARLLLV ELFLRYDSFD VEVGTSTLGS SVTVTSLKKA TFCYP74 (Not Monooxygenase)
CYP75
>CYP75A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ---- MMLLTELGAA TSIFLIAHII ISTLISKTTG RHLPPGPRGW PVIGALPLLG AMPHVSLAKM AKKYGAIMYL KVGTCGMAVA STPDAAKAFL KTLDINFSNR PPNAGATHLA YNAQDMVFAH YGPRWKLLRK LSNLHMLGGK ALENWANVRA NELGHMLKSM SDMSREGQRV VVAEMLTFAM ANMIGQVMLS KRVFVDKGVE VNEFKDMVVE LMTIAGYFNI GDFIPCLAWM DLQGIEKRMK RLHKKFDALL TKMFDEHKAT TYERKGKPDF LDVVMENGDN SEGERLSTTN IKALLLNLFT AGTDTSSSAI EWALAEMMKN PAILKKAQAE MDQVIGRNRR LLESDIPNLP YLRAICKETF RKHPSTPLNL PRISNEPCIV DGYYIPKNTR LSVNIWAIGR DPQVWENPLE FNPERFLSGR NSKIDPRGND FELIPFGAGR RICAGTRMGI VMVEYILGTL VHSFDWKLPS EVIELNMEEA FGLALQKAVP LEAMVTPRLQ LDVYVPCYP75
CYP76
>CYP76A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ---- FGNMFDLAGS APYKKIACLK EKYGPILWLK IGSSMNTMVI QTANSASELF RNHDVSFSDR PIVDVNLAHN YYKGSMALAP YGNYWRFSRR ICTVEMFVHK RINETTNIRQ ESVDKMLRLD EEKASSSGGG GEGIEVTRYM FLASFNMVGN MIFSKDLVTD PESKQGSEFF NAMIGIMEWA GVPNISDIFP CLKMFDVQGL RKKMERDMGK GKEITKKFIE ERIEERKKGE KNRSIKDLLD VLIDFEGSGK DEPDKLSEDE ITVIILEMFL AGTETTSSSV EWALTELLRH PQAMAKVKLE ILQVIGPNKK FEECDIDSLP YMQAVLKEQL RLHPPLPLLI PRKAIQDTKF MGYDIPKGTQ VLVNAWAIGR DPEYWDNPFE FKPERFLESK VDVKGQNYEL IPFGAGRRMC VGLPLGHRMM HFTFGSLLHE FDWELPHNVS PKSINMEESM GITARKKQPL KVIPKKACYP76
CYP77
>CYP77A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ---- IFTAFSLLFS LFIFLLTRKP KSKTPNLPPG PPGWPIVGNL FQVAGSGKQF FEYIRDLKPK YGSIFTLKMG SRTMIIVASA ELAHEALIQK GQIFASRPRE NPTRTIFSCN KFSVNAAVYG PVWRSLRRNM VQNMLSPSRL KEFREFREIA MDKLIERIRV DAKENNDVVW ALKNARFAVF YILVAMCFGV EMDNEEMIER VDQMMKDVLI VLDPRIDDFL PILRLFVGYK QRKRVNEVRK RQIETLVPLI EKRRSVVQNP GSDKTAASFS YLDTLFDVKV EGRKSGPTNA ELVTLCSEFL NGGTDTTATA LEWGIGRLME NPTIQNQLYQ EIKTIVGDKK VDENDIEKMP YLNAVVKELL RKHPPTYFTL THSVTEPVKL AGYDIPMDTN VEFFVHGISH DPNVWSDPEK FDPDRFLSGR EDADITGVKE VKMMPFGVGR RICPGLGMAT VHVNLMLARM VQEFEWFAYP GNNKVDFSEK LEFTVVMKNP LRAKVKLRICYP77
CYP78
>CYP78A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ---- MAMASAACSC TDGTWWVYAL PALLGSDTLC AHPALLAGLI FLATVSVALL AWATSPGGPA WTNGRGASAS LLSWDPVVCP CSAASSRCPG AAAPRPRRDG PRRRPRAKEL MAFSVGDTPA VVSSCPATAR EVLAHPSFAD RPVKRSAREL MFARAIGFAP NGEYWRRLRR VASTHLFSPR RVASHEPGRQ GDAEAMLRSI AAEQSASGAV ALRPHLQAAA LNNIMGSVFG TRYDVTSGAG AAEAEHLKSM VREGFELLGA FNWSDHLPWL AHLYDPSNVT RRCAALVPRV QTFVRGVIDE HRRRRQNSAA LNDNADFVDV LLSLEGDEKL GDDDMVAILW EMVFRGTDTT ALLTEWCMAE LVRHPAVQAR VRAEVDAAVG AGGCPTDADV ARMPYLQAVV KETLRAHPPG PLLSWARLAT ADVPLCNGMV VPAGTTAMVN MWAITHDAAV WADPDAFAPE RFLPSEGGAD VDVRGVDLRL APFGAGRRVC PGKNLGLTTV GLWVARLVHA FQWALPDGAA AVCLDEVLKL SLEMKTPLVA AAIPRTACYP78
CYP79
>CYP79A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ---- MATMEVEAAA ATVLAAPLLS SSAILKLLLF VVTLSYLARA LRRPRKSTTK CSSTTCASPP AGVGNPPLPP GPVPWPVVGN LPEMLLNKPA FRWIHQMMRE MGTDIACVKL GGVHVVSITC PEIAREVLRK QDANFISRPL TFASETFSGG YRNAVLSPYG DQWKKMRRVL TSEIICPSRH AWLHDKRTDE ADNLTRYVYN LATKAATGDV AVDVRHVARH YCGNVIRRLM FNRRYFGEPQ ADGGPGPMEV LHMDAVFTSL GLLYAFCVSD YLPWLRGLDL DGHEKIVKEA NVAVNRLHDT VIDDRWRQWK SGERQEMEDF LDVLITLKDA QGNPLLTIEE VKAQSQDITF AAVDNPSNAV EWALAEMVNN PEVMAKAMEE LDRVVGRERL VQESDIPKLN YVKACIREAF RLHPVAPFNV PHVALADTTI AGYRVPKGSH VILSRTGLGR NPRVWDEPLR FYPDRHLATA ASDVALTEND LRFISFSTGR RGCIAASLGT AMSVMLFGRL LQGFTWSKPA GVEAVDLSES KSDTFMATPL VLHAEPRLPA HLYPSISICYP79
CYP80
>CYP80A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ---- MDYIVGFVSI SLVALLYFLL FKPKHTNLPP SPPAWPIVGH LPDLISKNSP PFLDYMSNIA QKYGPLIHLK FGLHSSIFAS TKEAAMEVLQ TNDKVLSGRQ PLPCFRIKPH IDYSILWSDS NSYWKKGRKI LHTEIFSQKM LQAQEKNRER VAGNLVNFIM TKVGDVVELR SWLFGCALNV LGHVVFSKDV FEYSDQSDEV GMDKLIHGML MTGGDFDVAS YFPVLARFDL HGLKRKMDEQ FKLLIKIWEG EVLARRANRN PEPKDMLDVL IANDFNEHQI NAMFMETFGP GSDTNSNIIE WALAQLIKNP DKLAKLREEL DRVVGRSSTV KESHFSELPY LQACVKETMR LYPPISIMIP HRCMETCQVM GYTIPKGMDV HVNAHAIGRD PKDWKDPLKF QPERFLDSDI EYNGKQFQFI PFGSGRRICP GRPLAVRIIP LVLASLVHAF GWELPDGVPN EKLDMEELFT LSLCMAKPLR VIPKVRICYP80
CYP81
>CYP81A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ---- MERFYYVAVA TFVLVFLLHH LLTRKKQQRL PPGPRFAYPI LGHLPLLKKP LQTSFADLVS RHGPIIHLRL GRRHAVVVGS AAVAKECFSG ELDVAIANRP HFPSAREVTF DYSVLTAVNY GALWRTMRRV STVHLLSAHR VNVMSDTVIA RELRVMVRRL ARASASAPGD AARVELKRRL FDLSHSVLME IMAQTRNTYS DDPEEDMSRE ARDMKDIIEE IIPLVGAANL WNYVPLLRWL DLYGAKRKLA DVVNRRDLIF DNMIGAERQK LRQLERKKGE AHASESDKMG MIGVMLSLQK TEPDVYTDTF INALVSNLLA AGTETTSTTL EWAMSLLLNH PDVLKRAQEE IESNVGRDRL LDKNDLPRLP YLHCIISETL RLYPPTPMLL PHEASTDCKI HGYDVPAGSM VLVNAYAIHR DPAMWEDPEE FRPERFELGR AEGKFMMPFG MGRRRCPGEN LAMRTMGLVL GALLQCFDWT RVGDREVDMA TATGTIMSKA VPLEAQCKPR ANMSAVLQKICYP81
CYP82
>CYP82A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ---- FVLNYLNTTT IAFISLISLL FFLFRFSKVS HTKEPPIISG SWPLLGHLPL MRNTQTPHKT LGALVDKYGP IFTIKLGATN ALVLSNWELA KECFTKNDIV VSSRPKPVAV ELMSYNQAFI GWAPYGAYWR QLRKIVTLEI LSNRRIELLS HIRVSEVQTS IKELVNVWSN QISSQYGLLD DTKSSSTNDE PSTTDYVSVE LKKWFAQLTL NMVLRMVVGK RCFGDVDVEN KEEAKRFLEN IRDFMRLIGT FTVGDGVPFL KWLDLGGHEK EMKKCAKKFD VMLNEWLEEH REKKGLGSED KVVGERDFMD AMLLVLKDKP IEGFDVDTII KATTLELILG GSDTTAGTLT WAMCLLLKHP HVLEKLKEEL NTYIGKERCV NESDINKLVY LHAIIKETLR LYPPAPFSSP REFTEDCTIG GYHIKKGTRL MPNLWKIHRD PSVWPDPLEF KPERFLSTHK DVDVRGQNFE LLPFGSGRRM CAGMSLGLHM VHYILANFLH SFEILNPSPE SIDVTEVLEF VTTKATPLEV LVKPCLSFKC YESMCYP82
CYP83
>CYP83A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ---- MEDIIIGVVA LAAVLLFFLY QKPKTKRYKL PPGPSPLPVI GNLLQLQKLN PQRFFAGWAK KYGPILSYRI GSRTMVVISS AELAKELLKT QDVNFADRPP HRGHEFISYG RRDMALNHYT PYYREIRKMG MNHLFSPTRV ATFKHVREEE ARRMMDKINK AADKSEVVDI SELMLTFTNS VVCRQAFGKK YNEDGEEMKR FIKILYGTQS VLGKIFFSDF FPYCGFLDDL SGLTAYMKEC FERQDTYIQE VVNETLDPKR VKPETESMID LLMGIYKEQP FASEFTVDNV KAVILDIVVA GTDTAAAAVV WGMTYLMKYP QVLKKAQAEV REYMKEKGST FVTEDDVKNL PYFRALVKET LRIEPVIPLL IPRACIQDTK IAGYDIPAGT TVNVNAWAVS RDEKEWGPNP DEFRPERFLE KEVDFKGTDY EFIPFGSGRR MCPGMRLGAA MLEVPYANLL LSFNFKLPNG MKPDDINMDV MTGLAMHKSQ HLKLVPEKVN KYCYP83
CYP84
>CYP84A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ---- MESSISQTLS KLSDPTTSLV IVVSLFIFIS FITRRRRPPY PPGPRGWPII GNMLMMDQLT HRGLANLAKK YGGLCHLRMG FLHMYAVSSP EVARQVLQVQ DSVFSNRPAT IAISYLTYDR ADMAFAHYGP FWRQMRKVCV MKVFSRKRAE SWASVRDEVD KMVRSVSCNV GKPINVGEQI FALTRNITYR AAFGSACEKG QDEFIRILQE FSKLFGAFNV ADFIPYFGWI DPQGINKRLV KARNDLDGFI DDIIDEHMKK KENQNAVDDG DVVDTDMVDD LLAFYSEEAK LVSETADLQN SIKLTRDNIK AIIMDVMFGG TETVASAIEW ALTELLRSPE DLKRVQQELA EVVGLDRRVE ESDIEKLTYL KCTLKETLRM HPPIPLLLHE TAEDTSIDGF FIPKKSRVMI NAFAIGRDPT SWTDPDTFRP SRFLEPGVPD FKGSNFEFIP FGSGRRSCPG MQLGLYALDL AVAHILHCFT WKLPDGMKPS ELDMNDVFGL TAPKATRLFA VPTTRLICALCYP84
CYP85
>CYP85A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ---- MGAMMVMMGL LLIIVSLCSA LLRWNQMRYT KNGLPPGTMG WPIFGETTEF LKQGPNFMRN QRLRYGSFFK SHLLGCPTLI SMDSEVNRYI LKNESKGLVP GYPQSMLDIL GTCNMAAVHG SSHRLMRGSL LSLISSTMMR DHILPKVDHF MRSYLDQWNE LEVIDIQDKT KHMAFLSSLT QIAGNLRKPF VEEFKTAFFK LVVGTLSVPI DLPGTNYRCG IQARNNIDRL LRELMQERRD SGETFTDMLG YLMKKEGNRY PLTDEEIRDQ VVTILYSGYE TVSTTSMMAL KYLHDHPKAL QELRAEHLAF RERKRQDEPL GLEDVKSMKF TRAVIYETSR LATIVNGVLR KTTRDLEING YLIPKGWRIY VYTREINYDA NLYEDPLIFN PWRWMKKSLE SQNSCFVFGG GTRLCPGKEL GIVEISSFLH YFVTRYRWEE IGGDELMVFP RVFAPKGFHL RISPYCYP85
CYP86
>CYP86A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ---- MEALNSILTG YAVAALSVYA LWFYFLSRRL TGPKVLPFVG SLPYLIANRS RIHDWIADNL RATGGTYQTC TMVIPFVAKA QGFYTVTCHP KNVEHILKTR FDNYPKGPMW RAAFHDLLGQ GIFNSDGDTW LMQRKTAALE FTTRTLRQAM ARWVNGTIKN RLWLILDRAV QNNKPVDLQD LFLRLTFDNI CGLTFGKDPE TLSLDLPDNP FSVAFDTATE ATLKRLLYTG FLWRIQKAMG IGSEDKLKKS LEVVETYMND AIDARKNSPS DDLLSRFLKK RDVNGNVLPT DVLQRIALNF VLAGRDTSSV ALSWFFWLVM NNREVETKIV NELSMVLKET RGNDQEKWTE EPLEFDEADR LVYLKAALAE TLRLYPSVPQ DFKYVVDDDV LPDGTFVPRG STVTYSIYSI GRMKTIWGED CLEFRPERWL TADGERFETP KDGYKFVAFN AGPRTCLGKD LAYNQMKSVA SAVLLRYRVF PVPGHRVEQK MSLTLFMKNG LRVYLQPRGE VLACYP86
CYP87
>CYP87A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----CYP87
>CYP87A3 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ---- MQPYLQLASL RLATTIPLAP RLYDANLLAA SGAAMASSMA YIALLCAALA AVVALLRWAY RWSHPRSNGR LPPGSLGLPV IGETLQFFAP NPTCDLSPFV KERIKRYGSI FKTSVVGRPV VVSADPEMNY YVFQQEGKLF ESWYPDTFTE IFGRDNVGSL HGFMYKYLKT LVLRLYGQEN LKSVLLAETD AACRGSLASW ASQPSVELKE GISTMIFDLT AKKLIGYDPS KPSQVNLRKN FGAFICGLIS FPLNIPGTAY HECMEGRKNA MKVLRGMMKE RMAEPERPCE DFFDHVIQEL RREKPLLTET IALDLMFVLL FASFETTALA LTIGVKLLTE NPKVVDALRE EHEAIIRNRK DPNSGVTWAE YKSMTFTSQV IMEIVRLANI VPGIFRKALQ DVEIKGYTIP AGWGIMVCPP AVHLNPEIYE DPLAFNPWRW QGKPEITGGT KHFMAFGGGL RFCVGTDLSK VLMATFIHSL VTKYSWRTVK GGNIVRTPGL SFPDGFHIQL FPKN
CYP88
>CYP88A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ---- MLGVGMAAAV LLGAVALLLA DAAARRAHWW YREAAEAVLV GAVALVVVDA AARRAHGWYR EAALGAARRA RLPPGEMGWP LVGGMWAFLR AFKSGKPDAF IASFVRRFGR TGVYRSFMFS SPTVLVTTAE GCKQVLMDDD AFVTGWPKAT VALVGPRSFV AMPYDEHRRI RKLTAAPING FDALTGYLPF IDRTVTSSLR AWADHGGSVE FLTELRRMTF KIIVQIFLGG ADQATTRALE RSYTELNYGM RAMAINLPGF AYRGALRARR RLVAVLQGVL DERRAARAKG VSGGGVDMMD RLIEAQDERG RHLDDDEIID VLVMYLNAGH ESSGHITMWA TVFLQENPDM FARAKAEQEA IMRSIPSSQR GLTLRDFRKM EYLSQVIDET LRLVNISFVS FRQATRDVFV NGYLIPKGWK VQLWYRSVHM DPQVYPDPTK FDPSRWEGHS PRAGTFLAFG LGARLCPGND LAKLEISVFL HHFLLGYKLA RTNPRCRVRY LPHPRPVDNC LAKITRVGSCYP88
CYP89
>CYP89A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----CYP89
>CYP89A2 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ---- MEIWLLILAS LSGSLLLHLL LRRRNSSSPP LPPDPNFLPF LGTLQWLREG LGGLESYLRS VHHRLGPIVT LRITSRPAIF VADRSLTHEA LVLNGAVYAD RPPPAVISKI VDEHNISSGS YGATWRLLRR NITSEILHPS RVRSYSHARH WVLEILFERF RNHGGEEPIV LIHHLHYAMF ALLVLMCFGD KLDEKQIKEV EFIQRLQLLS LTKFNIFNIW PKFTKLILRK RWQEFLQIRR QQRDVLLPLI RARRKIVEER KRSEQEDKKD YVQSYVDTLL DLELPEENRK LNEEDIMNLC SEFLTAGTDT TATALQWIMA NLVKYPEIQE RLHEEIKSVV GEEAKEVEEE DVEKMPYLKA VVLEGLRRHP PGHFLLPHSV TEDTVLGGYK VPKNGTINFM VAEIGRDPVE WEEPMAFKPE RFMGEEEAVD LTGSRGIKMM PFGAGRRICP GIGLAMLHLE YYVANMVREF QWKEVQGHEV DLTEKLEFTV VMKHPLKALA VPRRCH
CYP90
>CYP90A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----CYP90
>CYP90A2 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ---- MVSLPTLLLL FAASAAAIFL HRAFSRRKFR LPPGSYGLPF IGETLQLISA YKSSNPEPFM DERVRRYGSI FMTHVFGEPT VFSADPELNR FILQNEGKLL DCSYPGSISN LLGKHSLLLM KGALHKRMHS LTMSFANSSI IKDHLLHHID RLIGLNLDTW SDRVTLMDQA KKITFELTVK QLMSFDPDEW TESLRKEYVL VIEGFFTLPL PLFSTTYRRA IKARTKVAEA LTLVVRQRRE EYNQGKEKKS DMLGALLASG DHFSDDQIVD FLLALLVAGY ETTSTIMTLA VKFLTETPLA LAQLKEEHDQ IRARSDPGAP LEWTDYKSMV FTQHVVNETL RVANIIGGIF RRATTDIDIK GYTIPKGWKV FASFRAVHLN PEYYKDARTF NPWRWQSNSS EAANPANVYT PFGGGPRLCP GYELARVVLS VFLHRIVTRF SWVPAEEDKL VFFPTTRTQK RYPIIVKRRN ANHV
CYP91X→Rename to CYP81
>CYP91A1X>CYP81D1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ---- MEETNIRVVL YSIFSLIFLI ISFKFLKPKK QNLPPSPPGW LPIIGHLRLL KPPIHRTLRS FSETLDHNDG GGVMSLRLGS RLVYVVSSHK VAAEECFGKN DVVLANRPQV IIGKHVGYNN TNMIAAPYGD HWRNLRRLCT IEIFSTHRLN CFLYVRTDEV RRLISRLSRL AGTKKTVVEL KPMLMDLTFN NIMRMMTGKR YYGEETTDEE EAKRVRKLVA DVGANTSSGN AVDYVPILRL FSSYENRVKK LGEETDKFLQ GLIDDKRGQQ ETGTTMIDHL LVLQKSDIEY YTDQIIKGII LIMVIAGTNT SAVTLEWALS NLLNHPDVIS KARDEIDNRV GLDRLIEEAD LSELPYLKNI VLETLRLHPA TPLLVPHMAS EDCKIGSYDM PRGTTLLVNA WAIHRDPNTW DDPDSFKPER FEKEEEAQKL LAFGLGRRAC PGSGLAQRIV GLALGSLIQC FEWERVGNVE VDMKEGVGNT VPKAIPLKAI CKARPFLHKI ISCYP91X→Rename to CYP81
CYP92
>CYP92A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ---- MEPATWAVFL GIALCAAAAL FLSRGRRPVY NPPPGPKPWP IIGNLNLMGE LPHRSMNELS KRYGPLMQLR FGSLPVLVGA SVEMAKLFLK TNDAAFSDRP RFAIGKYTAY DFSDLLWAPS GPYLRQARRI CATELFSATR LESFEHIRDE EVRVMLRQLR QAAGRTVRLR DYLQMLALGV ISRIVLGNKY VMEEVADGEG DSAPAITPAE FREMVDEFFA LHGAFNIGDY IPWLDWLDLQ GYVARMKRMK ARFGRFLERV LDVHNERRLR EGGNFVAKDM LDVLLQLADD TSLEVQLSRD NVKAITQDLI IAGTDSNANT LEWAVSELLK NPKILAKAME ELNHVIGPDR LVTESDLPRL PYIEAVLKET MRVHPAAPML APHVAREDTS VDGYDVLAGT VLFINVWAIG RDPGLWDAPE EFRPERFVES KIDVRGHDFQ LLPFGSGRRM CPGINLALKV MALSLANLLH GFEWRLPDGV TAEELSMDEA FKLAVPRKFP LMVVAEPRLP ARLYTGACYP92
CYP93
>CYP93A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----CYP93
>CYP93A2---- 1234567890 1234567890 1234567890 1234567890 1234567890 ---- MAYQVLVICV VSSIVFAYIV WRKERKKKLP PSPKGLPIIG HLHLVSPIPH QDFYKLSLRH GPIMQLFLGS VPCVVASTAE AAKEFLKTHE INFSNRPGQN VAVQFLTYVF GPYGPSVKFI KKLCMSELLG GRMLDQFLPV RQQETKKFIK RVLQKGIAGE AVDFGGEFMR LSNNIISRMT MNQTSSEDEK QAEEMRMLVA DVAELMGTFN VSDFIWFLKP FDLQGFNKRI RKTRIRFDAV LDRIIKQREE ERRNNKEIGG TRQFKDILDV LLDIGEDDSS EIKLTKENIK AFIMDIFVAG TDTSAATMEW AMAELINNPC VLEKARQEID AVVGNSRIIE ESDIVNLPYL QAIVRETLRI HPGGPLIVRE SSKSVVVCGY EIPAKTRLFV NVWAIGRDPN HWENPFEFRP ERFFENGQSQ LDVRGQHYHF IPFGSGRRSC PGTSLALQIV HVNLAIMIQC FQWKFDNGNN KVDMEEKSGI TLPRAHPIIC VPVPRLNPFP VM