Reference
Cytochrome P450 HomepageDavid R. Nelson, (2009) The Cytochrome P450 Homepage. Human Genomics 4, 59-65.AlphafoldJohn Jumper, Richard Evans, Alexander Pritzel, et al. - Highly accurate protein structure prediction with AlphaFold. Nature, 1–11, doi: 10.1038/s41586-021-03819-2 (2021)ColabfoldMirdita M, Ovchinnikov S and Steinegger M. ColabFold - Making protein folding accessible to all. bioRxiv, doi: 10.1101/2021.08.15.456425 (2021)Localcolabfoldhttps://github.com/YoshitakaMo/localcolabfoldReference
CYP101-CYP299, CYP1001-CYP1050Cytochrome P450 HomepageComprehensive Bacterial P450sDavid R. Nelson, (2009) The Cytochrome P450 Homepage. Human Genomics 4, 59-65.https://drnelson.uthsc.edu/comprehensive-bacterial-p450s/
CYP1041, CYP1042, CYP1043, CYP1044, CYP1047, CYP1051-Fanele Cabangile Mnguni, David R. Nelson, and Khajamohiddin Syed et al.,More P450s Are Involved in Secondary Metabolite Biosynthesis in Streptomyces Compared to Bacillus, Cyanobacteria, and MycobacteriumInt. J. Mol. Sci. 2020, 21(13), 4814; https://doi.org/10.3390/ijms21134814
CYP1067, CYP1100, CYP1119-CYP1134Mohammad Parvez, David R Nelson, Khajamohiddin Syed et al.,Molecular evolutionary dynamics of cytochrome P450 monooxygenases across kingdoms: Special focus on mycobacterial P450s Sci. Rep. 6, 33099; doi: 10.1038/srep33099 (2016).
CYP1094, CYP1136, CYP1146, CYP1156, CYP1158-1159, CYP1177, CYP1184, CYP1185CYP1137, CYP1320, CYP1136, CYP1719, CYP1762, CYP1851, CYP1912, CYP1976, CYP2029, CYP2287, CYP2337, CYP2725Makhosazana Jabulile Khumalo, David R Nelson, Khajamohiddin Syed et al.,Comprehensive analyses of cytochrome P450 monooxygenases and secondary metabolite biosynthetic gene clusters in CyanobacteriaInt J Mol Sci . 2020, 21(2), 656. doi: 10.3390/ijms21020656.
D. R. Nelson's
D. R. Nelson's
https://twitter.com/P450nelson/status/1501396401317883904
Method
Localcolabfold (model1_ptm, recycle=6 or CaRMSD < 0.4, centerd and rotated around proximal Cys)runner_P450align.py -f CYPs/CYPXXXA1.fasta -nm 5 -mr 6 -alirunner_P450align.py -f CYPs/CYPXXXA1.fasta -nm 5 -mr 6 -ali -upMaestro (Protein preparation Wizard)proPKa pH 7.0, save as pdbHeme was extract from proximal-ligand-aligned crystal structure of CYP101A1-CYP150A1Heme was added hydrogen using maestro builder, save as mol2ES_scoreMaestro output Method
CYP2006
>CYP2006A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----CYP2006
>CYP2006A2 (2546770101)Streptomyces afghaniensis 772---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSVTHDLVRR SATGRPVIDF DHHSPAYRDT WKQLAARFHA TGSPVAWTEH 00500051 HGGYWVVASW EEVQRIGSDW ETFTSVNDLT GTENGGKGQL IPQMPYRLHL 01000101 GESDPPLHTE RRRIEAPFFT PKALRQWDPV ARQYLDEALD KVAGRGQAEL 01500151 IDDVIIPTTA RTTLYVLGYD ADDWHDAAYA AHEGVYLLPD DPRYPHEAQA 02000201 RLRVRFRDML AARGQTPAGD VLSALATGTV QGEPLGLEVA ESMVNALVFG 02500251 GFDTTTAATA SALIHLTQHP DQAERVRTDA AYRKNAIEEF LRFWPPGTGI 03000301 ARTAVRDTEI LGQPIARGES VYMWLAGANR DPLKFPDPDR LDLERDNARD 03500351 HVSFSTGHHR CLGSPLAKAE LDAMLETILT RLPGLRIDPD AVVGYPSIGG 04000401 AHGYISVPAT FTPTSTPTEV
Alphafold2
Alphafold2
Heme Docked
Heme Docked
PDBj
PDBj
CYP2018
>CYP2018A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----CYP2018
>CYP2018B1 (2515918513)Streptomyces sp. BoleA5---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MLPPKPTALD ARSAAGLVRQ WRRAVEPEAL AAAYDALAAA GPLVPTPWGA 00500051 LLVTGYEECR QVLTGREWLT LGARWRDAHR PGWRASASTV GLCETPLQQD 01000101 PPEHTARRRP LNAVLAPRVV REAAERLVEP LTERHVGEFA AAVRRDGAAD 01500151 VVARVCRPLP TAVLAEMAGL PEWIDRGWLA AESAAMVRVE ELAAPPSVVR 02000201 RADAAALALL DAYDRALAER LRHPARDLLS RWAAEDPAGA RYLLLTLFSA 02500251 GVPTTAALLA GTALALTADP ALAERIRQDP GFAGPLTDEL LRWDPPGRVV 03000301 TRVTDADTEL GGRPVPAGRV VHALIGAAHR DPQRFAAPHV FDPDRPAQRL 03500351 LAFGGGLHYC LGSHLARAQA LAFARAFARE LPGARAAAPP VRHAGPSMAD 04000401 IARLTIHSPL T
Alphafold2
Alphafold2
Heme Docked
Heme Docked
PDBj
PDBj
CYP2027
>CYP2027A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----CYP2027
>CYP2027A2 (2685035264)Streptomyces griseochromogenes---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MTTAPVRLPE HLDHPFSPAG RINPHPAYRW LRTNDPVHHD AASGLWLVTG 00500051 HADCQTVLRD PRFSAAKGQR ERARDDALPP SMLTTDPPDH HRLRAPGALL 01000101 LGPSAVRSVA GDLTRDVDEL LDRLGRRPAA ERPDAVADIG RPLATAVFGR 01500151 LFGLAAAEYA RFETLARAAS INLDPMVPPA RAALGRTAAA ALTRYLDAHC 02000201 ATLARGGRAA PLAAFAADDR LTRSEMLGVL NLAVVGGWQP LAELVGNALC 02500251 SLLPDRAAVR RLAAGDDTSG EGGDAGGEAA RRAVDELLRL EAPIPFTARV 03000301 TTDTVELAGG TLPAGARVLA VISAANRDPA VFADPDELRV DRHPNPHLAF 03500351 GGGPHFCLAA QLVRQAGGLL LPRLLRRFPG MRGPHGVPDW DRCLVPRRLR 04000401 VFPVDLGVPG ADDKDPGTAE EDHG
Alphafold2
Alphafold2
Heme Docked
Heme Docked
PDBj
PDBj
CYP2029
>CYP2029A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----CYP2029
>CYP2029A3 (2685035264)Streptomyces griseochromogenes---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MLTKEIPVAK GLPLIGNLVF LSKNNRKFEQ FCIENYRKLG PLYKACVLGK 00500051 EFKIFAGPEA NMFVTQQGIH HLTTREAFMV MEKEFGENTI MVLDGDSHRR 01000101 SRKIVDQFLN AAAIAQYVNP MIQVTLNFIK DWQIGQRIEL FHAALPKIIL 01500151 NQLSSALLSC TLTDDFVEDI YICISTLLKV TSEQKGESAL RKPTYLKVKN 02000201 RMLTFVKQLV DERRKTGQVT DSPDVVDFLL SVKDDDGQLL TEEEIFSYIP 02500251 IIIAAGLDTV AHTSAFLIYE ILKHPEIYQQ VMAEVSAVFD NRIPDLEDMK 03000301 NMKVLRGAAM ETLRLHPVVF MTQRYVQHPF DYQDYRVESG QIMYFASGVS 03500351 HFLPELFPNP YTFDVERYAP PREEHKQPGA FAPFFLGPHR CAGARLAEIQ 04000401 LMLTAATILY TVQPQLDPPN YTMKTALYTE ESPTLAVKGN FYIKTRRKIP 04500451 LSSLA
Alphafold2
Alphafold2
Heme Docked
Heme Docked
PDBj
PDBj
CYP2034
>CYP2034A1 (2541336578)Streptomyces turgidiscabies Car8---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MLSRCPYAHT ADVQPDPCAD YLALKEVPPV HRDEVLGVWF ITGTRQVAEL 00500051 IRHPSLSSAW PERGRTVLHD PAGAGESGHR TSGTVRRWFM FNDGTRHKAL 01000101 RGLVSPLFSA GRLARLRPFV EEQVGALIGA RSGRIDVMAE LAVPLSSRVI 01500151 CRVLGLPADL APRLDGWAQD IAALLVADYL PEASRRGHLA LSQIEDAVNT 02000201 ALESPDLSPD SGLALLKTAR DNGGIDEADI AAVAGLIVYA GFETTSTFIG 02500251 KAVRSVLHAG AWQDLRIADP VTAAEELFRF DTSVRQIARV ATSPIAVEGQ 03000301 CIEAGDLVLL MLGAANRDPG IFVDPDALNL DRNIKKHLAF GQGQHYCLGA 03500351 GLARMEVQII LERMSATWQD VKLVEPPTTR LHFGIPVLER LELEVSCYP2034
Alphafold2
Alphafold2
Heme Docked
Heme Docked
PDBj
PDBj
CYP2035
>CYP2035A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----CYP2035
>CYP2035A2 (2519822269)Streptomyces sp. LaPpAH-185---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 VVDVNDPTRS PRHDRPDAEN RSVEAAGGGC PYGGETGTGS TGGPRVPATT 00500051 ASGTAHVEDT ERTGDFDSHD PALAEDPFPA YARLRSRCPV SWSEAWGGFW 01000101 VAAGHAEASR AGREGVFRTG HLLPDGTIQG VTIPPLGQTG RLVPLEADPP 01500151 RNLKYRKLLS SFYSAGRVRA RMPEFRRLAR ESLDAVISQG TGDLVTALTL 02000201 RVPGIVTMRD LGLPDDRWFE MDSLVHRALL AAPHDLPGAR AHAQQITMAL 02500251 VEELDVRQEH GSDSADRSVL PALIEATVDG EPVSDEDILS MLYLILLGID 03000301 PVSSLTATAL LHLAEHPRLR DRLIADPSLV PRAAEEYARW MSPVQGTSRT 03500351 AGEDTELGGR TLRAGERVFV SWASANRDEA VFPHPDTVDL DRDTAGHLAF 04000401 GAGPHYCLGA SLVRALFTVM LEEVLTRIPD YRVSDRDAVT WFPDITSFYG 04500451 VTSLPVQFTP QSARIA
Alphafold2
Alphafold2
Heme Docked
Heme Docked
PDBj
PDBj
CYP2045 (memory over of RTX-3060)
>CYP2045A1 (2689317861)Streptomyces reticuli---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MAGTARHGSE LPGVDLWVPA VRNDTAGAVP VAGPDELFGE RAGSAGRDDT 00500051 LCGIFARRVR EHGDRTALID GERRYSYRTL DEVSNAWAQE LTRLGAAPGD 01000101 IVPVSLPRSA ELVVAVLAVL KTGAAYSLLA PEWPRARQEE LVALLDARIV 01500151 VTAGPAAWDR PVFTPPPVER SERRRTAPPA PALSPDAPAT VFFTSGSTGA 02000201 PKAVVSPHRA TVSLFDDPVF ADFGPGSVMP LAAALPWDAF SLELWGMLLS 02500251 GGTSVLIDGP YLLPAVLREL TAAHRVNVLW LTASLFNMFV EEDPGCFGGL 03000301 RRLFVGGERL SPRHVRTFLA AHPSITLVNG YGPVESTVFA TVHEITAEDC 03500351 ARENGIPIGR AVAGRRIEVR RDGEPCAAGE PGELFIGGDG LALVYLGQPG 04000401 LTEEKFVRVH GPGRPRRMYR TGDLVSADAD GVLHFHGRIG RQVKLRGHRV 04500451 ELAEIEALVR QAAGVTDCVA VPRTDRDGTC HGIAAFYTTE HATGPEPGEL 05000501 RRDVAARAPG YLVPDRLEHV ERFPLSANGK VDHRRLAAAL PPPDTAPAVD 05500551 RATARDPLEA TVRSAFAEVL RRGDVPSDAS FFALGGTSLD AGRLCTRLGA 06000601 LLGEPVPISL VMTHPTPGGL LEELRRSRPD APHSAPAGPR PSSPHEAVEL 06500651 LGMQAAFAMA HEFQPDDLAP LCPSVWRIDG PLDLDALAGA VRDVGLRHEA 07000701 LRAVYEAVPR PRARVDAAVP PASLHVLPPA AGEEEALRLL TGHVLAPLAI 07500751 GSGEVWRCAV VTHASTAYFA LCVHHVAFDA WSQRILLEEL ALAYTARRAG 08000801 REPDFGRPPA RLADVQRERA VQLAPHRLTR QLEFWQEALT GLPPLRFGSG 08500851 PVPPGDSPGH AEAPDDTPGG TELSFTVPGP DVTTLEKAAL DAGTTLFTVL 09000901 LAGYGTVLHR TLGQDAFGIG VPVAKRDIPS SDSFVGCLIN TLCIPFRGAG 09500951 GDFTSVLNAT HDIVTRAFAA QDVPFAEVVG TVRPARSGRN PLFQTMFAFQ 10001001 DVGQGEFGLP DCRVAPVDAG HPRAMHELVA EVWPQADGSL KVSFAWQPER 10501051 VPARTVRELL TAYRELLTTV AAEPATTARR HTADQGVPAV GVSFWEDPYP 11001101 VYKTFQDRSG IFWDEMLEVW VAAGRSAVNT VLRSPAMSSD WLRLNASGPV 11501151 SREFPELERM LRGWFMLMDP PNHTALRRTM QSFFVRSRVD SLAGEFRDIV 12001201 AARLDQLRPL DHVDLAHDFA TPVASGVLAR VLDVPVDVIA AAAVHMAPIA 12501251 SFLAQPHKRE FAERAAAAVG RLDGLYRELA PHLSEGSALF PLLGDDPAAP 13001301 EAAYLHTAHL LSFAGQETTA GLIASGLLHL LREPRRYREV ATGQADPDAV 13501351 VEEMLRFDTP VPQVPRVALS DVTVEGRTIR AGDRVLALLA AANRDWRNTP 14001401 DADVLDFTRR QRHMAFGVGI HYCLGAPIAR GAAKTAISEW TAAFPSARLA 14501451 PETVRWAVGT GYRRLESAQV QLVERGNERCYP2045 (memory over of RTX-3060)
Alphafold2
Alphafold2
Heme Docked
Heme Docked
PDBj
PDBj
CYP2054
>CYP2054A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----CYP2054
>CYP2054A2 (2547559704)Streptomyces acidiscabies 84-104---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MAVSVEPGQL REGRPFDPYG AHRDDPYSFL ADLVEMEPVF YAPLLDAWCV 00500051 TRREDMVAVL RDDRNFTARD HNPRSKVELP DDVSRMLRTW RGAGALAVGS 01000101 LDPPEHSRIR DVLNIGFTPA RVRAFEPTVR AIATNLAERT AASPEFDFIT 01500151 EYAVPYALDV ICRRLGIPDE YVERCRVWSE QRIELMMLQS YTDPDWLREY 02000201 ARGLMEFGAF ARSLVQERLA SPQDDLISEL LHDGRAGTTL TAEEVSVQVP 02500251 TLIFAGHMTC AEALGTIVHQ QLRSPGGWAD VVDGKVATRD LVEEGLRFDS 03000301 PLAGMYRTAL QDVTVGGVHL AAGSRLLLLY GAAGRDSRTH ACPAGFSPGS 03500351 ESSAHLAFGH GIHFCLGAGF ARLELEAAIE AVAATMPGLT LAPGLPPRHR 04000401 PVFPLRALSE LRVRTSGRSA GGVDDTLASV ER
Alphafold2
Alphafold2
Heme Docked
Heme Docked
PDBj
PDBj
CYP2073
>CYP2073A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----CYP2073
>CYP2073A2 (2518244903)Streptomyces bottropensis ATCC 25435---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MTTTLPHFDP FSPDALAHPG GALADGPLAL GSVGYTVLSF ELGTTVLRDS 00500051 RFQNAALKLM EDFGITGGPV HDFRAQSMLM AEGPRHLRLR TPLARFMGPA 01000101 TVENIRGVLR EIIQDLAADL DPSVPVDFHG GIDRRLPARV YCYLAGAPAE 01500151 DAPKVASLSE RTLSLLNRDP SMTPVILGAY EELFAYLKDL VARKRAEGLG 02000201 EDMLSFLIAQ HDAGKLSEDE LLNEATAMLE ASSVNTTHQT GLVVWTLLRN 02500251 REIWQRLVED PTLIPAAVVE VLRLYPRPGI VSRIATEDIE LNGTVIPAGS 03000301 DVHVAVWSAN RDPARFENPA DFMLGRERNQ PLTFSTGSHN CLGQGLARVE 03500351 MEEVVTYLAE HFPNAVVVEE GTEIGQAGGR WLVKSLTVDL KP
Alphafold2
Alphafold2
Heme Docked
Heme Docked
PDBj
PDBj
CYP2076
>CYP2076A1 (645984453)Streptomyces sp. AA4---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MAEIVQRLWR HFARQEPFGK DAPSFFAELA ERAPVVRFDG MWVISGYDLV 00500051 TRLCTHPGFP MAAPVFQENV RRDNPQFVRF FSGTMSVRAA EEHQRLRSVL 01000101 TGAFSGRRLA ALRGRIDEVV AELLAEPLRR GEAEFVADIA TPLPARVTAV 01500151 LLGIPAADRD LVTARATGMM NQLAAGFLAE THPEAGPPIT AAEFAELREY 02000201 VAGQLARRRA EPAEDLIGHL AQAQQDGKLS ADEAVDMVLL LFMTGLDTVT 02500251 AALANTLVVL SERPEIAAAL AADEQCADRV FAEAIRLRTP VAFGSRQVTH 03000301 DLSVGTLDFK AGDTVILAFA AANLDPRKFA DPLEFRWDRP ITGNVAFGHG 03500351 SYYCLGSALA AMTAQSLLQA VHHRLPTPSR PLAELPWRQS LAFPTPRVLP 04000401 VTFAPALAES GARCYP2076
Alphafold2
Alphafold2
Heme Docked
Heme Docked
PDBj
PDBj
CYP2080
>CYP2080A1 (651526682)Streptomyces griseoaurantiacus M045---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MAHSEHLDAV QISSYAGVKE VMNKVAEAFT GTYSTLWPLT EPLPVDQQVF 00500051 PSADPPRHTR QRKLFVKALS ASRIAHMRPF SERLAERLLD GILARGTGFD 01000101 LVTAYSRRIS EGHIAELLGL PEELRERFMY LSTLTELSTA DGKGMGYRAE 01500151 LDEWQAQLAG MVRERRAAGE DSDDLITRLC FAEDEGDRLS ELEVASLIRA 02000201 MIRAGNTTSA AALTNTVAAL ERHPEQKVKY LADIEGLTPS LVEEGLRYDG 02500251 PALGLWRRCA RETTVQGYPL TPGDRVFTVT AAANHDPEVY DRPDEFLIDR 03000301 DWKELPPHLT FGWGIHHCIG VNLARLELET SLAALYRRLP GLRLEPGAEI 03500351 PQVPGPVFRN WLSLPMEFDP VSTGAGRCYP2080
Alphafold2
Alphafold2
Heme Docked
Heme Docked
PDBj
PDBj
CYP2180
>CYP2180A1 (2515787339)Streptomyces vitaminophilus DSM 41686---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 VARDVRQVLA SDHFWSERAA DRRNGALTEE DRERREALRD FYAHWPVFSD 00500051 GDRHRRLRRA AIRLLRDVVT PGLPSSCERL VAHRLNQSRA GTFDGMERVA 01000101 RPLAREAVVA LTGRAGADRL IELGGVVMNE LATPRIEMAR IDAALEVIDA 01500151 LRDWLRTAPA GPPSAFVAGL AELWEDDTLG PDVATALLTQ IVTGAYEPTV 02000201 TALCLVGERV TGGVLAESPR QTVLEEVVRL ATPFRFASRY ARRPVTVGPH 02500251 RLDVGDGIVL CLGTANFDPD HYPEPLELRR RGRTPRSFSF GAGEHYCPGA 03000301 PLAQAITGVL LDSLTRLGVH LSVERVEREP ELSMLRYRRL DGRLVHRDVP 03500351 APRVPHRDVR PGTAFRCPLT TSLGAAVTVL VIDTDPGLDD AHALAMALTP 04000401 SPTRPRLPVA AVCTVAGNVD IDTVTANARW LLGAYGGAAA ETPVHRGAAG 04500451 PIAGPTVRAA DIHGADGLGD LPRWAVPDVP ERAAPAALTL IDAARRHPGG 05000501 TTVVALGPLT NVALAVRLEP RLPELLDRVV VMGGAIHGRG NLTLNAEFNF 05500551 GADPAAADLV LASFPRLTLV SWETTLAHCF TPAEFAGFFA GDGRAAGVLR 06000601 RIVENRFATD PGYAGRPAYL RADPLAMAVA LDPGVVTGAE HHRVCVGYGP 06500651 GGLAHGLTAV DWCDTRTDRP PVEIVLEVDR DRLLELLTIH CYP2180
Alphafold2
Alphafold2
Heme Docked
Heme Docked
PDBj
PDBj
CYP2189 (No Cys)
>CYP2189A1 (647548725)Streptomyces clavuligerus---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSFPSSSVDL LDERVLADPC PVHAALRAVG PVVRLARHHA WAITHHQAVE 00500051 EALTTGILIP RPADSSTPAC PGHHPRPDTA AVRAVQTVLR QAREVLAGHT 01000101 HAGVTDAAAA ARHLTARTVL ALAGTPRPAP LRLPARKPVT AALAALLHPT 01500151 PPPTRPKTRP AGPGARPDGA GKGLSPVVRC ALAHADVTAA GLTETLWQLA 02000201 HHPDQWTRVR AQPSRLAPAA LHEALRLQPP QPHQVFTAAA TVLLSGVEVA 02500251 AGDEVWLLHR AAGRDPAQWG PTADSFDIHR PRTNPRLPGS HCPTATALAR 03000301 AQTTTLLQAL AAHPYLTPAA APGRTHTTTQ HTWLFAPLTT NPTTSHNPRG 03500351 LPASCYP2189 (No Cys)
Alphafold2
Alphafold2
Heme Docked
Heme Docked
PDBj
PDBj
CYP2238
>CYP2238A1 (2579965594)Streptomyces sp. Mg1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSAPSTRPLL SLYRAIYAAA VTATLLVAGF GLWTGLSLRS WPVALVSVAV 00500051 AGLLVLAVRR RLTEFRSRRH LPGPKPSFFL GNMSDLLLHG HGGRHESLQA 01000101 LHDEYGPLVC FHAAWGSAPF VSLSYVSPNL LRKELDSHRR ADRTVLSRSL 01500151 MGMAGGELHQ THRQVIAPSM AFRGVSERGS VLKDVSDRYV DKWKHVDEGY 02000201 EGLQSDLRDW SVNCLSAFLF GDDWDVGADL HAYHRALSAI EEEVSFRAFH 02500251 PFFVRWVFPR RRRRVRAAYH RVAAELGEVV TRREQRIPAA CPAHGATGAA 03000301 AATGAAGGDL LDRVTRAPWS AEDRVEELMS LILGGADPMS YVLSQALVML 03500351 SLDPHVQEKA RKTIEASSSC AQEGDPGPDP YVRNIVYETL RMFPPVPFSA 04000401 KFSDERAVVE QGMSIPPGTV IMWMKNAVGK NPEIFREAER FNPDRFDPER 04500451 FPADGEKRND TISSFLPFGA GPRHCVGNRL AEQQCIVLLT EILKNFHVVP 05000501 LRHIKVQFHS TISVVPSAVP VRLVPRCYP2238
Alphafold2
Alphafold2
Heme Docked
Heme Docked
PDBj
PDBj
CYP2266
>CYP2266A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----CYP2266
>CYP2266A2 (2584334378)Streptomyces leeuwenhoekii---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 VFLDRKSLWP HLLRWEKLAA DADGPFRLRF GTLFIADANA ARQVLVESAD 00500051 SYVEQSGFFR IGPTPLPREP RIQASRELIK VLAHHGPNSS FDIDRAVHEL 01000101 RDGRGRLRHQ RWGAELIRRY FAPVIAHERH AEINSLVDVY VTSSIVGDDI 01500151 VGHAIRGPHR SVPRIRAGFA EQLKRLPAGG TGANDLVDVV LSLRGELSPA 02000201 DRAQLLQRLV LSAVGFTGVA LEWVVLLGIQ HGYNSPAVRP EHIRSLVRET 02500251 LRLYPTAWRL VRVAAADHDM DGIWVRKGEH VLIGTHAIHR TGAVWDDPLH 03000301 FLPSRWEKLT DDQRKSYLPF GKGGAMCPAN GFALKALEHL GYLILHDFEG 03500351 DVRLRRRKPH VRTLLAPPAG WTRLTRKRTT SGSNGR
Alphafold2
Alphafold2
Heme Docked
Heme Docked
PDBj
PDBj
CYP2286
>CYP2286A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----CYP2286
>CYP2286A3 (2518246559)Streptomyces bottropensis ATCC 25435---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MTLRHLAPYD PLDPAHNADP AARLAEARDR CPVSQPRPGV HFLTLHDDVR 00500051 DVLTTHEVYS SVDNFALEGG AKTADLPAAP ITMLDPPDHT ALRARLRRWF 01000101 APAVIRKQEP RVRDIVTDVL DAWQPGQRAE IYHDLARQVP TRVVYAFLGL 01500151 PEEDWDRLHQ WADAIDDVVP IVPIDMPEFV ALCRYLGEQF AAQAAAPATG 02000201 DGVLDGLAHP ADGQPPLTPA EAVIHAFQLI VAATDTTASL ITNLLHELLA 02500251 DRSHWERLLA DRSLIPTAIE ESLRHDAPLQ YVLRTATQER EISGCPVKPG 03000301 DRLAASLQSA NWDDRAWGAD AADYSLDRPA GQATPMAFGY GIHTCLGAPL 03500351 ARLQSRVVLE QLLERFPELR LAPGYRREPA PGLVMVRRPA RLDVVL
Alphafold2
Alphafold2
Heme Docked
Heme Docked
PDBj
PDBj
CYP2287
>CYP2287A1 (ACB51997.1) Crocosphaera subtropica---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MNSTNQSSVS LKPNLLDRIL NRFQAWAIEN PQNFVSLTLL PIIGFLEGFL 00500051 ANFLFSYPVY LDMKKRKLGS TFCCAGQVVL ADFKTIETNL TSPQARTWYL 01000101 GISPLSARHC PQIDIGGRNV FLISLSDTGT EGNDHDAFRH CVEDYFFTDE 01500151 MKVRQHDPVG RELLETLGAD YRELASENRL EGFFIDENRG LMSFLIRYLH 02000201 YVIFAIDPHD DSSIAALTNF HYTRRGTLHY FAASRILERF NLLGWSEIPG 02500251 MIEAVGTIYE KSPVLANFQE NNPKYNNMTR RELAKLMVAL MSIAALQGPL 03000301 HLGRTAMGYQ SLPPYKGLKT SEIDVTAYWD RLDLDNPSSI KLFLLECGRL 03500351 FTPVSASHRV ATDSFTTTIA GKTRTFPPGT IILIPMILGM LTETVWGATP 04000401 YEFQPQRENL CPYHMGFHSV GDRHAGRICP GKDLALETLT DVIRIVGKVR 04500451 RSQLGLTSHCYP2287
Alphafold2
Alphafold2
Heme Docked
Heme Docked
PDBj
PDBj
CYP2307
>CYP2307A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----CYP2307
>CYP2307A3 (645208404)Streptomyces ghanaensis ATCC 14672---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MTANDAQKQG LCPVDLWSEE FNENFWETIG ALQQKASLGV HRQGSTPCYY 00500051 ATRYQDVFNV LRDAATYSSE GGVAILGGDN RSEPPKNEGR FLPEDLDAPA 01000101 HTEWRKVIDP FLTVKRVEAY ELTISKTIDE LLDAVLPNGR FKVLADFLRP 01500151 LQLKIIFTEL LHLPGEEIED WMHWSHDLFV GETPEIAAQA FASINKAAEE 02000201 LVLRRMADPI PDDLVSAVCT VKEIGGREPT LAERTAVVVP LAIAGTESVG 02500251 TLLSAIVHHL ATHPDDLAEL VADPGLVPVA VEEGLRMFAN VTALQRTVTR 03000301 DTELAGVPLE AGAKVWTSYN GANRDPEQFP DPHTWNLHRD EVRHVAFGVG 03500351 PHRCLGSNHA RLMMRKVLAR LLERMPRFTL APDQTISRFS MPTRGIHEVI 04000401 IDVPAQG
Alphafold2
Alphafold2
Heme Docked
Heme Docked
PDBj
PDBj
CYP2337
>CYP2337A1 (ABW25859.1)Acaryochloris marina---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MDVISYSIVT PQEFLGKRQQ LFGQNFAALG RIIVGEYNLA AKIIAEPQQR 00500051 EPYIGRFRCI PDRFSKNFLL FLSDKEVKGD TTHKKARSAV LEVVFKPAFD 01000101 NTESQEAKDL LNQLATIANQ HGNPPALDDI SDDIQRTVIQ YIMLVLLEVK 01500151 LSPQQLSSLK TLFFSSKPKE SLLISRVKPL APSANKLQEV KRLEGIALNL 02000201 IENSPVMSRY VPTTENDLSR TELSTLLLEA IAIAGCLGSE SLLRSLIAKV 02500251 PRDLEIDVDN RHEVLRVVLE TARRHSPVNN INTIAQTETE VTINGRKRKF 03000301 PKGTLFSANI GLANLDSTVF ENPLDFNPHR DNLLAALSFN SVGEAKRREC 03500351 PGRSIAEKMG SDLLVALQCK TVKSCYP2337
Alphafold2
Alphafold2
Heme Docked
Heme Docked
PDBj
PDBj
CYP2340
>CYP2340A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----CYP2340
>CYP2340B2P (2712584497)Streptomyces avermitilis---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MGSPRYVIYA SATTPDLVAA KYAPKVHGFL ARLFAESNAG KPLMHEYYEN 00500051 YFDLYWDLHL GVTGEAIPPE VRTIGAGFTA VLGHWYPTED IVRENIMRVR 01000101 ELRPRLREWI DRRVQAVIDG DVQDPEGTFV HYWLKNGQGG EHFRREDIVF 01500151 ECFHNFLAFS QWGNMLYRTM ALLDEGSGDP AVRSWFERAM TNGPDAADGG 02000201 AFTPLDRYVM ELFRTVSPNG GSLSTVSTER GADPRSGSVL TLHPSVSDPR 02500251 HWRNPEEFDP DRYRGVPTSA DNAETRSRQA GLARCPFPPA PFTVRDGRRA 03000301 EMTNSAFGAV YGVVDGTAYP VCDAAGYAPF GFGYRRCGGE QLTTEFVKEF 03500351 LRTVWSRGIE FTTLDLERSE KLPVSPRTVI DDNIGFRQGP
>CYP2340Bx WP_238577422.1 [Streptomyces inhibens]---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSTPHAWVGL LPPTFDPDYI ERAVVPYLSS SEYVGERPAL PMIDLALSKE 00500051 NAAPPHFWGM LYDGWAPDPK EGTTVFITGY DQRVPDNERK KIYASATTPD 01000101 LCAAKYAPKV HGFLARLFAE TNAGKPLMHE YYQNYFDLYW DLHLGVTGEA 01500151 IPPEVRSIGA GFTAVLGHWY PTEDIVRENI MRVRELRPRL KEWIDRRVQA 02000201 VIDGDVHDPE GTFVHYWLKN GQGGEHFRRE DIVFECFHNF LAFSQWGNMI 02500251 YRTMALLDAG HGDKAVRSWF ERTMTNSPDT ADGGAFTPLD RYVMELFRTV 03000301 SPNGGSLSTV STERGAEPRL GSVLTLHASA SRDPRHWRNP EEFDPDRYRA 03500351 APTSADNAET RSRQAGLTRC PFPPAPFTVM DGRRADVTNS AFGAVYAVVD 04000401 GTAYPVCDTA GYAPFGFGYR RCGGEQLTTE FVKEFLRTVW SRGIEFTTLD 04500451 LEHPEKLPVS PRTVIDDNIG FRQGP
Alphafold2
Alphafold2
Heme Docked
Heme Docked
PDBj
PDBj
CYP2349
>CYP2349A1 (2545382156)Streptomyces rimosus rimosus ATCC 10970---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MDNPYPLYRR LRETSPVLWD PVRHHWTVTR HQEVTQALRS PALHAVPRRL 00500051 GPRTPPTLRL LNSAMLDSDP PEHTRRRRVF TQAFTPRLTA DLAPAITHRV 01000101 DALLDRVHES GHMDLIEDLA TPLPLHVIGQ LLGIPPQDRP RLHAGARGYA 01500151 RLWGGDDTDQ TTIGQAVTDI TRAIDHCREL ITQRRNAPRS DLISRLASPA 02000201 GRAGSLSDGE LAANLFMVFT AGHYTTTDFL GNSVLALAHH PHQWQQLCTD 02500251 PALASSAVTE LLRYEAPVQF VIRLAAQDLT LAGQRITAGQ LVVLLLAAAN 03000301 RDPRAFPDPD RLDLTRTPNH HLTLGFGIHS CLGTALARLQ GEITLSRLAA 03500351 RMPRLRPAGD TIRWKTTTGL RGPLRLSVHW DCYP2349
Alphafold2
Alphafold2
Heme Docked
Heme Docked
PDBj
PDBj
CYP2357
>CYP2357A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----CYP2357
>CYP2357B2 (2513739447)Streptomyces sp. AmelKG-F2B---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MTVQLTGPTD RDNELSMMGV YTPRYVEDPY PLYRRAREIN PVLWDPTMGD 00500051 GGAWMVTGYE PALTTLRDSV FSARRPQWDP GTHSPEQAAP LRALYSQLFV 01000101 TDAPDHKRLR KLMTKPFLPR AVEAMRDGIE RGARALLDAV LPRGGMDFMT 01500151 DYAMALPSAV VCGVLGVPVE ERELFWKRIL SWGLLVDEGP LSKEHPGYHL 02000201 ASVGKYMDYF REQLRRRESE RTDDLMQTLA DAWADGGFTS EEELLGNLIF 02500251 MLTAGQTTTA HQIGNSVLAL LDHPDVLARL TADPSLVPYA TPELMRYDSS 03000301 VQLTKRRPVR DVELGGQTIR AGEEIYVWMG AAHRDPKAFP DPDRLDVDRP 03500351 RSQNLALGHG AHYCLGGQLG QLINEVAVRQ FVERVRRPEV DRAKIHRTET 04000401 PTFRGPHSMP MTFTS
Alphafold2
Alphafold2
Heme Docked
Heme Docked
PDBj
PDBj
CYP2365
>CYP2365A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----CYP2365
>CYP2365C1 (2546762687)Streptomyces aurantiacus JA 4570---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MGRLEADPYP IYGRLRAEEP VAWVPAVGAW LVTRWDDVRH VLTSPESYTT 00500051 TNDASPLSTY CGSQNVLNQE GDRHAAIRKA VGDRFRQETA PAVTAHARSV 01000101 AARRLGDLAD RDHADLMAEY FEPVSVETAS WLLGLDAVDG VDTATLTRWS 01500151 TGLTAALYNP TKAGAAHVTG AAVSGAMDRT LTPHLARLLD QPDDSPLSAL 02000201 VHAAGPADDA SWGVHQTLAT VRMMTSAVRE PGWLAGNTLH ALLTHPEQMD 02500251 ALRADPGLLD AAVYEGIRWA APVGAVGRLT TKPLVLGGQE LPAGAPVAPG 03000301 IASANRDEAA FPAADRFDLL RARTTTPLSL GLGRHECLAA HVVPAIVEGA 03500351 LRQLLERFPE LHLEQDVRPY GWKFRKLDTL PVGWRDRSAA GA
Alphafold2
Alphafold2
Heme Docked
Heme Docked
PDBj
PDBj
CYP2378
>CYP2378A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----CYP2378
>CYP2378A2 (2574339998)Streptomyces yeochonensis CN732---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSALAPSSSL RLFDDRVLAD PYPSYGALRC TGAAVHLEEY GVWAIPRHTD 00500051 VAAILKDPDT FGSDGGIALT ALANQEILGG TVLASDGARH IKLRRVLSKQ 01000101 LAPRAMKALT SRITARAERL VDQYTASGRF DAIALSRHMV CDTVMELMGL 01500151 PDADRDVLLD GAAATFDVFG PHGDRYQQAL PLASRMVEML HEKLIREKVN 02000201 RESWMGAIFE AVDAGEIDEG DAVPLASAYT AAGIDTTVLG LADCLVQLAQ 02500251 HPQQWQLLRR DPDRWATPAF HESLRREAPI QGFGRLLTQA TDVGGVHLDA 03000301 GEQVWLLYGS AGRDPRQWGD EADVYDIQRP DNHQHLAFGG GPHLCAGIPL 03500351 AELQARAVLR ALAARCSHLT LDGEPVRVLN NLLRGHSAAP IAVELAPSSN 04000401 SADRSPEACQ QGPVT
Alphafold2
Alphafold2
Heme Docked
Heme Docked
PDBj
PDBj
CYP2427
>CYP2427A1 (2519051957)Streptomyces sp. AmelKG-E11A---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 LTEQTVPRPP VPTGASQAEM LERYEDDRLG HLLSSARRFG PVCELTEGTV 00500051 LVSDPALVHD VLKRTNTDFL VTSNIRRDEV SGERGDPGTE AWMRGRRATQ 01000101 KGMGPAALAA HREWLAEETG RLIAGWRTRS SVTDPVTELE RLSARSFTRF 01500151 CFGTRDPGAA ARRTGELLAA LTPIISSPFH FPRAIRRFMP RYRRSVDAQR 02000201 SLERELRRAL DAPGGGGLVE SLADAGLDPE ASVRMLVSNG LASYRVPAAA 02500251 VTWTLVALAR HPAVADGLAG RLGRAGTDDG PGDADGDPLL AWTIAESLRL 03000301 WPPNWLILRT ANGEQSCGGW RLPPGASVIV SPYVVHRTAP SFAGDPDTFR 03500351 PERWSGLNPG PGEYLPYGIG SRWCVGKALA DLELTTIVAA LAREFRFSVR 04000401 TMAERPDVRT TLLPASLTLG LRPRCYP2427
Alphafold2
Alphafold2
Heme Docked
Heme Docked
PDBj
PDBj
CYP2540
>CYP2540A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----CYP2540
>CYP2540A2 (2561481897)Streptomyces sp. CNX435---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 LIDLLREFGS ELYSDPQACY AALRNEGPVH EVILPDGRRC HLVLNYSDAR 00500051 CLLSSDSLSN QRPGRENSHM LESDDPRHSM LRQAIASTFS KSNVRAMQPM 01000101 ISRIVDRQIS LLPPGEDVDL VEDFARLVPA LVIGRVLGIL SDDEPDLRRW 01500151 TTDILATDDG SQRMGDARAK LTRFVSEIFE RRRPVSHDGL IWELMTTRSR 02000201 KTNITDADLI STITLLIIAG HEATVNLINN AILCYLEFPD VPGELASGRA 02500251 HIDDLIAETL RYQPPLSLSA NRYLVRDLEL SGKTLEGDGS LVIASFASAN 03000301 RDGAKYESPD SFSLRRRKAS HLGFGSGSHH CLGNTLAIAE AHCAVSELIR 03500351 RYPDMTHRGE TQWRPSCISR SQRSLVVRLD QCRKSHTAQA SGKSIT
Alphafold2
Alphafold2
Heme Docked
Heme Docked
PDBj
PDBj
CYP2723
>CYP2723A1 (2519820409)Streptomyces sp. LaPpAH-185---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MDDVTAGTGL STLRADREVT PLEWFDELRE SHGMGWDETT GTWYVTRYDD 00500051 VYDLLRDPRL GAQVETYCPP GLTEEQQKTY WRVTEFIDRW PVFSDPPRHS 01000101 GMRRLLLPLF TAAAVARAAA AAADTVAVAG PAAAPDGLFA DVVRPALAAG 01500151 LCSLLDEPPE ALARLGDCAT RILAFGSIET YDPAAGLRAE KALDELTELV 02000201 RQRCAAPAGV LATALSRSLS DGTLDLLDAT AVYAQLVSGA LEPTAAAVAH 02500251 LLEVVTGPEG TGLDIKADVD GTIDEALRLV TPFHLAMRRA LTDVHIHGHR 03000301 VRAESRVVLV LVAANRDPRQ FAEPDAFRLD RAGARHVAFG RGRHACLGAA 03500351 LTRQVMREMV LELAASGVLE KLPPLRAVWN TDFGGRFVQD VVVAQDACYP2723
Alphafold2
Alphafold2
Heme Docked
Heme Docked
PDBj
PDBj
CYP2725 ??
>CYP2725A1 (2519820409)Streptomyces sp. LaPpAH-185---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MEVKDLTQCP VKDIVNVYLS KSAMNRSKDP RQNRLFYSMS PVGHRFLENI 00500051 DSEDPQFEAI SSLAKQVSKV LESNCKQGFE NRLKAYWASN LPAYPVCSIR 01000101 DSAFGAVLDE VWFAFFARAC PNPDLVVKAA HNILMVVKNR ETVDIKSRRN 01500151 AIALVADAVK LGLNPQLELQ EIELQETFTN IHEVIFALIV SSVDELSEGF 02000201 AHTVIALAQH APTPTSLDEF ALAFYEALRL YPLFTRSTRP SNDNTCLYSL 02500251 NYVNYHRRTD IFGKDALQYN WQRWQAKNWL GQTFIFGVAS NRSCPGRGSA 03000301 IEMVPRMVQV WMQTYQTQSY IRHTRNLPCG GLAIVTPIGK RVPWFLSWLH 03500351 FGAWIYSHAS FCLIQRAWVN HQNAKASNKR READHYYASL KALRIPAAAS 04000401 HGSVQPSRLS AKSCYP2725 ??
Alphafold2
Alphafold2
Heme Docked
Heme Docked
PDBj
PDBj