Reference
Cytochrome P450 HomepageNelson, DR (2009) The Cytochrome P450 Homepage. Human Genomics 4, 59-65.AlphafoldJohn Jumper, Richard Evans, Alexander Pritzel, et al. - Highly accurate protein structure prediction with AlphaFold. Nature, 1–11, doi: 10.1038/s41586-021-03819-2 (2021)ColabfoldMirdita M, Ovchinnikov S and Steinegger M. ColabFold - Making protein folding accessible to all. bioRxiv, doi: 10.1101/2021.08.15.456425 (2021)Localcolabfoldhttps://github.com/YoshitakaMo/localcolabfoldReference
Cytochrome P450 HomepageComprehensive Bacterial P450shttps://drnelson.uthsc.edu/comprehensive-bacterial-p450s/
D. R. Nelson's
D. R. Nelson's
https://twitter.com/P450nelson/status/1501396401317883904
Method
Localcolabfold (model1_ptm, recycle=6 or CaRMSD < 0.4, centerd and rotated around proximal Cys)runner_P450align.py -f CYPs/CYPXXXA1.fasta -nm 5 -mr 6 -alirunner_P450align.py -f CYPs/CYPXXXA1.fasta -nm 5 -mr 6 -ali -upMaestro (Protein preparation Wizard)proPKa pH 7.0, save as pdbHeme was extract from proximal-ligand-aligned crystal structure of CYP101A1-CYP150A1Heme was added hydrogen using maestro builder, save as mol2ES_scoreMaestro output AlphaFold2_advanced.ipynb (for the preparation of movie)Method
CYP151
>CYP151A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSSTTLDSVP SFDVTDPAFS ITSDEVHEAR EKSWYATTPY GLAVLRYEQV 00500051 NRLIKHPKLR QGSAAWPAHN GVTEGPFAEW FASWILNKEG EEHHRLRRLM 01000101 NPAFSPKLIG SLVPRFQALA NELIDNFAEP DRCEFVSEFA EPYAARVIAI 01500151 MLGLPEEEWK VISTESATIG LALGVTLRED LPKIEAAVQR LYEYSDELIA 02000201 DRRANPRDDF MTTLVNASRP DDGRLSDKEL RDAILLLIFG GFDTTRNQLG 02500251 LAMQTFMKHP DQWRLLGERP DLGGKAVEEV MRVNPTVRWV TREVVEDFEY 03000301 EGVTLKAGTT VHLYSESAGT DPRVFEPGFD ITAERKPHFG FGGGVHHCLG 03500351 HFVARSDMSE ALPLLARRLR DPHELPGATW LPDSGNTGPN TLPIGFTPAP 0400CYP151
Heme Docked
Heme Docked
PDBj
PDBj
CYP152 (Peroxygensase)
>CYP152A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MNEQIPHDKS LDNSLTLLKE GYLFIKNRTE RYNSDLFQAR LLGKNFICMT 00500051 GAEAAKVFYD TDRFQRQNAL PKRVQKSLFG VNAIQGMDGS AHIHRKMLFL 01000101 SLMTPPHQKR LAELMTEEWK AAVTRWEKAD EVVLFEEAKE ILCRVACYWA 01500151 GVPLKETEVK ERADDFIDMV DAFGAVGPRH WKGRRARPRA EEWIEVMIED 02000201 ARAGLLKTTS GTALHEMAFH TQEDGSQLDS RMAAIELINV LRPIVAISYF 02500251 LVFSALALHE HPKYKEWLRS GNSREREMFV QEVRRYYPFG PFLGALVKKD 03000301 FVWNNCEFKK GTSVLLDLYG TNHDPRLWDH PDEFRPERFA EREENLFDMI 03500351 PQGGGHAEKG HRCPGEGITI EVMKASLDFL VHQIEYDVPE QSLHYSLARM 04000401 PSLPESGFVM SGIRRKSCYP152 (Peroxygensase)
Heme Docked
Heme Docked
CYP153
>CYP153A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MNSVAEIFEK ITQTVTSTAA DVATTVTDKV KSNEQFQTGK QFLHGQVTRF 00500051 VPLHTQVRGI QWMQKAKFRV FNVQEFPAFI EQPIPEVATL ALAEIDVSNP 01000101 FLYKQKKWQS YFKRLRDEAP VHYQANSPFG AFWSVTRYDD IVYVDKNHEI 01500151 FSAEPVIAIG NTPPGLDAEM FIAMDPPKHD VQRQAVQDVV APKNLKELEG 02000201 LIRLRVQGVL DQLPTDQPFD WVQNVSIELT ARMLATLFDF PYEKRHKLVE 02500251 WSDLMAGTAE ATGGTVTNLD EIFDAAVDAA KHFAELWHRK AAQKSAGAEM 03000301 GYDLISLMQS NEATKDLIYR PMEFMGNLVL LIVGGNDTTR NSMTGGVYAL 03500351 NLFPNEFVKL KNNPSLIPNM VSEIIRWQTP LAYMRRIAKQ DVELNGQTIK 04000401 KGDKVVMWYV SGNRDERVIE RPDELIIDRK GARNHLSFGF GVHRCMGNRL 04500451 AEMQLRILWE ELLQRFENIE VLGEPEIVQS NFVRGYAKMM VKLTAKACYP153
Heme Docked
Heme Docked
CYP154
>CYP154A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MATQQPALVL DPTGADHHTE HRTLREGGPA TWVDVLGVQA WSVSDPVLLK 00500051 QLLTSSDVSK DARAHWPAFG EVVGTWPLAL WVAVENMFTA YGPNHRKLRR 01000101 LVAPAFSARR VDAMRPAVEA MVTGLVDRLA ELPAGEPVDL RQELAYPLPI 01500151 AVIGHLMGVP QDRRDGFRAL VDGVFDTTLD QAEAQANTAR LYEVLDQLIA 02000201 AKRATPGDDM TSLLIAARDD EGDGDRLSPE ELRDTLLLMI SAGYETTVNV 02500251 IDQAVHTLLT RPDQLALVRK GEVTWADVVE ETLRHEPAVK HLPLRYAVTD 03000301 IALPDGRTIA RGEPILASYA AANRHPDWHE DADTFDATRT VKEHLAFGHG 03500351 VHFCLGAPLA RMEVTLALES LFGRFPDLRL ADPAEELPPV PSLISNGHQR 04000401 LPVLLHAGCYP154
Heme Docked
Heme Docked
CYP155
>CYP155A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 DPGDHVVEPG GRRGRTAGVG GGHVVQDGRV SARKADRGRA GPACPVDRAA 00500051 DGTWRVHDFA VARALLRGPG TVQAGLGIET VEKLPPRVRR PVLYRDGPEH 01000101 REHRRQTARY FTPRRVDEHY REPMVRIAEE QLAVLRSAGE APLSDLAFGL 01500151 AVGVVSEVVG LRYSRPGIRR RLERFFPEEF GEPGLTSVRG LYWLVRQNTN 02000201 WLRIHLADVR PAVRAHRRRE HDDLISHLIA EGCSDVEILG ECLTFAAAGM 02500251 VTTREFVCLA AWHLFSDAEL LGHYRSADET GRLAVLQELL RLEPVIGSLR 03000301 RRATGPVELS CRDGPVTVRP GEYVEVHLDD ANADPKAVGE EPLLVRPERA 03500351 GAVGAGLSFG DGPHRCPGAH IALLETDVFL SRLFALDGVR MSGGPRVAFQ 04000401 EAIDGYEIRD LTVALPRAGR GCYP155
Heme Docked
Heme Docked
PDBj
PDBj
CYP156 !!FW!!GA!!
>CYP156A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MTLPSTETAP TGEPGRIALY APEFAADPHA AYRSMRRTHG PLVPVDLAPG 00500051 VPATLVIGYY QARRILNDPL RFPADPRAWE KLIPATCPVR PMMEWRPNAL 01000101 RSGGAEHTRY RSANTHAIDQ VDQHGLRALV EQVASDAIEG FRTAGSADLL 01500151 TQYSFPIAFR VLSALLGCPD EIGQRIADGM AKIFDTTNAD QGNLILAQAV 02000201 SDLVTLRRTH PGDDITSRLA LHPVRLTDEE MSHQLVTLYG AGIEPMTNLI 02500251 SNTILKILTD EEFSADLHAG LSTVRDALDA VLYTDPPMAN YCISYPPYPV 03000301 DVEGVLLPAD QPVVISMAAA NNDPALTEGV PAGQHGGNRA HLAWSTGPHT 03500351 CPARSHAYLI AETAVTHLLD ALPETDLARP AAELVWRPGP FHRALESLPV 04000401 TFPAAQSAAH CYP156 !!FW!!GA!!
Heme Docked
Heme Docked
PDBj
PDBj
CYP157 !!GΔ!!_post Cys is short_!!not aligned by my method!!
>CYP157A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSTDAHDVPG AVPLGGPRFQ TDPALLYRQM RREHGAVTPV VLDGDVPAWL 00500051 VLGYRELHQV TGDPVLFSRD SDLWNQWENI PDDWPLLPMI GRRQPSILYT 01000101 VGERHRERAA MISDALEAVD PHLLRGHAER FADELVDRLC AKGEADLVGD 01500151 YAMLLPVRVL ARLYGFPDEQ GPALVTALND MIDGRERALA GQTHLGTSMA 02000201 RLLADRKAAP ADDVASRMLA DESGFTEEEV AQDLMVMMAA GHQPTADWIG 02500251 NSLRLMLTDD RFAASLFGGR NSVAEAMNEV LWEDTPTQNV AGRWAARDTQ 03000301 LGGRRIRAGD LVLLGLQGAN SDPQVRTDGS ALTGGNNAHF SFGHGEHRCP 03500351 FPAQEVAEVI ARTGIEVVLD RLPDIDLAVP AGSLTRRPSP WLRGLTELPV 04000401 RFTPTTALGG TSACYP157 !!GΔ!!_post Cys is short_!!not aligned by my method!!
Heme Docked
Heme Docked
PDBj
PDBj
CYP158 !!FY!!
>CYP158A1 C_1 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MTQETTTLTG QSPPPVRDWP ALDLDGPEFD PVLAELMREG PLTRVRLPHG 00500051 EGWAWLATRY DDVKAITNDP RFGRAEVTQR QITRLAPHFK PRPGSLAFAD 01000101 QPDHNRLRRA VAGAFTVGAT KRLRPRAQEI LDGLVDGILA EGPPADLVER 01500151 VLEPFPIAVV SEVMGVPAAD RERVHSWTRQ IISTSGGAEA AERAKRGLYG 02000201 WITETVRARA GSEGGDVYSM LGAAVGRGEV GETEAVGLAG PLQIGGEAVT 02500251 HNVGQMLYLL LTRRELMARM RERPGARGTA LDELLRWISH RTSVGLARIA 03000301 LEDVEVHGTR IAAGEPVYVS YLAANRDPDV FPDPDRIDLD RDPNPHLAYG 03500351 NGHHFCTGAV LARMQTELLV DTLLERLPGL RLAVPAEQVA WRRKTMIRGP 04000401 RTLPCTWCYP158 !!FY!!
Heme Docked
Heme Docked
CYP159
>CYP159A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSTAQQVPDI LSPEFAANPY PAYRTMRDSA PLIRHEATQS WIVSRYEDVE 00500051 RVFKDRAGQF TTENYDWQIE PVHGRTILQL SGREHAVRRA LVAPAFRGAD 01000101 LQERFLPVIE RNSRELIDAF RHTGRADLVA DYATRFPVNV IADMLGLDKA 01500151 DHDRFHGWYT SVIAFLGNLS GDQEVAAAGA RTRTEFAEYM IPVIRERREN 02000201 PGDDLLSTLC AAEVDGVRMS DEDIKAFCSL LLAAGGETTD KAIAGIFANL 02500251 LAHPEQLAAV REDRSLIPRA FAETLRYTPP VHMIMRQTAT DVTLSGGTIP 03000301 AGATVTCLIG AANRDETRYR DPDRFDIMRD DLTTTTAFSA AADHLAFALG 03500351 RHFCVGALLA KAEVEIGVGQ LLDALPGLRT EDGFEVVERG VFTRGPQSLP 04000401 VRFTPAACYP159
Heme Docked
Heme Docked
PDBj
PDBj
~CYP134A1
CYP160 !!GA!!
>CYP160A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MTSAAPPAFP FPPGPGGTVP PEYARLLTDD PVAEVRLADG SRIWLVTRHE 00500051 DVRTVLTDGR FSRHRAAMLP GSGFGRSQGS GIVDLDPPEH GRLRGPVVAA 01000101 FGASRTARFA PRIEAAAEAA LDRLPAGSGT VDLVAAYTAP FAGRVTAEFL 01500151 GLPGDRWQDV TSDVELLLLP RGATEQALKE ARGRLGQVLD ELLAARRAEP 02000201 GDSVTDTLLD AEELTDDDRR LLLHGLIISG FITIRDLLAR HLFGVLSSPG 02500251 LAARLREDPS VLPSAVQELL RYYPSSNDGL LRVATEDVVL SGRRVAAGDA 03000301 VLPLVSAASR DPEVFADPHV LDIERVADRG IAFGAGQHAC PATGLAVTEL 03500351 TVGIGRLLAA FPRIALAVPP EEVEHSSELL PLGVRSLPVV PGPRNCYP160 !!GA!!
Heme Docked
Heme Docked
PDBj
PDBj
CYP161
>CYP161A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSTPTAPPSL KAEVPPVLRL SPLLRELQSR APVCKVRTPA GDEGWLVTRH 00500051 TELKQLLHDD RLARAHADPA NAPRYVHNPF LDLLVVDDFD LARTLHAEMR 01000101 SLFTPQFSAR RVMDLTPRVE ALAEGVLAHF VAQGPPADLH NDFSLPFSLS 01500151 VLCALIGVPA EEQGKLIAAL TKLGELDDPA RVQEGQDELF GLLSGLARRK 02000201 RITPEDDVIS RLCLKVPSDE RIGPIASGLL FAGLDSVASH IDLGTVLFIQ 02500251 HPDQLAAALA DEKLMRGAVE EILRSAKAGG SVLPRYATAD VPIGDVTIRA 03000301 GDLVLLDFTL VNFDRTVFDE PELFDIRRAP NPHLTFGHGM WHCIGAPLAR 03500351 VNLRTAYTLL FTRLPGLRLV RPVEELRVLS GQLSAGLTEL PVTWCYP161
Heme Docked
Heme Docked
CYP162
>CYP162A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MRVDLSDPLL YRDSDPEPVW SRLRAEHPVY RNERANGEHF WAVMTHGLCT 00500051 DMLTDPRVFS SQNGMRLDSD PQVLAAAAGK MLNITDPPRH DKIRKVVSSA 01000101 FTPRMVSRLE ATMRETAAKA IDEALAAGEC EFTRVAQKLP VSVICDMLGV 01500151 APADWDFMVE RTRFAWSSTA LDEAEEARKV RAHTEILLHF QDLAAERRRE 02000201 PKDDLMSALV CGEIDGAPLT DQEILYNCDA LVSGGNETTR HATVGGLLAL 02500251 IDNPDQWHRL RDEPALMPSA IQEIVRYTSP VMHALRTATE DVEFGGERIS 03000301 AGDHVVAWLP SANRDEKVFD DPDRFDIERE PNRHLGFIQG NHYCIGSSLA 03500351 KLELTVMFEE LLARVEVAEL AGQVRRLRSN LLWGFDSLPV KFVPRACYP162
Heme Docked
Heme Docked
PDBj
PDBj
CYP163
>CYP163A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSTRPTVSPS ELEQIDLASP VLHAEYELDE IFRHLRADEP VYWQQPRNEQ 00500051 PGFWVISRHA DVNEVYKDKE HFTTEHGNAL ATLLTGGDSA SGAMLAVTDG 01000101 VRHHQVRNVL SRGFSARMLD LIAHTLQETV DGLLLAALER GECDAAQDIA 01500151 ADVPLGAICD LLEIPHADRK YLLGLTSHAW STDYADEPPE ESWVAKNEIL 02000201 LYFSKLLKER RGGVREDMVS LLANCRIDGD PLKAAEQMAN CYGLMIGGDE 02500251 TGRHAITGTI LALIQNPDQW RALKNGDVDL NTATEEALRW TVPSLHGGRK 03000301 ATGDVVINGR RINAGDVVSV WISSANRDET VFDAPDEFNL ARTPNKHFTF 03500351 AYGSHYCLGH YLGRMEVYAV LDGLRRLVGD LEQIGEERWI YSSILHGMSS 04000401 LPIRITGCYP163
Heme Docked
Heme Docked
CYP164
>CYP164A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MRTCVPTRTC VYAFIEYLSH NRPMGTNPPS LVEAQMLLLR LIDPGTRADP 00500051 FPVYRALIDY GPMQLPGMPL TVFSSFSDCD EALRHPLSAS DRLKATLAQQ 01000101 AIAAGAEPRP FYASSFMFLD PPDHTRLRKL VSKAFAPKVV QALEGDIAAL 01500151 VDSLLDKGAA AGQFDVIADL AFPLAVAVIC RLLGVPYEDA PEFGRVSALL 02000201 VQSVDPFITI TGEPPEATEE RLRAGVWLRD YLEQLVKCRR GTPGEDLISR 02500251 LIELDESGDQ LTEEEIIATC GLLLVAGHET TVNLIANAVL AMLRNPSQWK 03000301 ALSSNPQRAP LVVEETLRYD PAIHLIGRVA AKDMTIGQTT LTEGDTMVLL 03500351 LAAANRDPAV YSRPDEFDPD RPSSRHLAFA VGSHFCLGAA LARLEATVTL 04000401 SAISARFPQV QLAGELVYKP NVAMRGMSAL PVQVCYP164
Heme Docked
Heme Docked
CYP165
>CYP165A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MFEESNALRG TEIHRRDRFA PGPELRSLMG EGTMSILQPP DSPGGRTGWL 00500051 ATGHDEVRQV LGSDKFSAKL LYGGTVAGRI WPGFLNQYDP PEHTRLRRMV 01000101 TSAFTVRRMQ DFRPRIEQIV QASLDAIEAA GGPVDFVPRF AWSVATTVTC 01500151 DFLGIPRDDQ ADLSRALHAS RSERSGKRRV AAGNKYWTYM TEIAARARRD 02000201 PGDDMFGAVV RDHGDAITDA ELLGVAAFVM GAGGDQVARF LAAGAWLMVE 02500251 HPDQFALLRE KPDTVPDWLN EVERYLTSDE KTTPRIAQED VRIGDQLVKA 03000301 GDAVTCSLLA ANRRKFPAPE DEFDITRERP VHVTFGHGIH HCLGRPLAEM 03500351 VFRAAIPALA QRFPKLRLAE PDREIKLGPP PFDVEALLLE WCYP165
Heme Docked
Heme Docked
CYP166
>CYP166A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MTDAISFEVP WDRTDKFDPP AVFDSLREER PLAKMVYPDG HVGWIVSSYE 00500051 LVREVLSDLR FSHSCEVGHF PVTHQGQVIP THPLIPGMFI HMDPPEHTRY 01000101 RKLLTGEFTV RRASRLIPRA EAVAAEQIEV MRAKGAPADV VMDFAKPLVL 01500151 RMLGELVGLP YEERDRYVPA VTLLHDAEAD PAEAAAAYEV AGKFFDEVIE 02000201 RRRQRPQDDL ISSLVTEDLT QEELRNIVTL LLFAGYETTE GALATGVFAL 02500251 LHHTDQLAAL RAEPEKLDAA IEELLRYLTV NQYHTYRTAL EDVKLEGELI 03000301 KKGDTVTVSL PAANRDPAKF GCPAELDIER DTSGHVAFGF GIHQCLGQNL 03500351 ARIELRAGFT ALLRAFPELR LAVPADEVPL RLKGSVFSVK KLPVSWCYP166
Heme Docked
Heme Docked
CYP167 !!FY!!
>CYP167A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MTQEQANQSE TKPAFDFKPF APGYAEDPFP AIERLREATP IFYWDEGRSW 00500051 VLTRYHDVSA VFRDERFAVS REEWESSAEY SSAIPELSDM KKYGLFGLPP 01000101 EDHARVRKLV NPSFTSRAID LLRAEIQRTV DQLLDARSGQ EEFDVVRDYA 01500151 EGIPMRAISA LLKVPAECDE KFRRFGSATA RALGVGLVPQ VDEETKTLVA 02000201 SVTEGLALLH DVLDERRRNP LENDVLTMLL QAEADGSRLS TKELVALVGA 02500251 IIAAGTDTTI YLIAFAVLNL LRSPEALELV KAEPGLMRNA LDEVLRFDNI 03000301 LRIGTVRFAR QDLEYCGASI KKGEMVFLLI PSALRDGTVF SRPDVFDVRR 03500351 DTGASLAYGR GPHVCPGVSL ARLEAEIAVG TIFRRFPEMK LKETPVFGYH 04000401 PAFRNIESLN VILKPSKAGCYP167 !!FY!!
Heme Docked
Heme Docked
CYP168
>CYP168A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MDDAFSEEGS AQPRHDAQRP ALAPRSDGFD IHTYHPDFVA DPYPLLRLIR 00500051 SRAPVCRDQA SIWWISRYAD VSACLRDRRF SADPARLGAA GVRQGGASWF 01000101 GHQQLQPLAR FYDNFMLFND APRHTRLRRL FAPAFGPDAV RRWEARIEVL 01500151 VEELLDSLLE RREPDLLRDF AEPLTIRVAA ELFGFPREDT GQLLPWGRDL 02000201 AAGLDLAASH GDAGQINRSA VAFSDYLQRQ ARGWSDGSSR PPSGAAPSIL 02500251 DGAAMLEAGL GLEDLVAAYA MVFMAAFETT ISMVGNATLA LLTHPDQLDL 03000301 LRRCPELAAN AVEELLRFDG AVRGGVRCTL EEVEIGGQRI PPGEKVWLSF 03500351 LAANRDPEMF AAPDRLQLQR ANAKQHVAFA HGPHYCLGAY LARLELQCAL 04000401 RGLVRRRFAL ASEPTDLRWR RSSVFRTLER LPIVPEGDAQ KTCECYP168
Heme Docked
Heme Docked
PDBj
PDBj
CYP169
>CYP169A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MQQTIDCPIR RRLAHLPWAN DGRAGVRHWL EMQRDPLAWL QKMHVAQPDL 00500051 AVARMGPQRL WCLFHPQAVQ ELMVDRRDDL QRWQPALCML KQWNGRSFMM 01000101 REGAPAQARR KEVRPHLAPP PASEVRRLAA EWGERVEEGR EYDLDLEMAA 01500151 FSVTLSGHAL FDVDLQPSAY RIAKAVRLLS RVALLEMSTG LPLGHWFPSK 02000201 LCPRKRWALG QLREAVGEVA ERSPRPLADL RDELCTLLMA SHQSTGVTLT 02500251 WSLLLLAQRP ELLARLRAEL AGVNWTAIRS VADLRDCALL RAVLQECLRL 03000301 YPPAYGLAPR QVTADIEVFG QRLKRGDVTM VSSWITQRDP RWFEAPLEFR 03500351 PERFLEPARW PRGAYFPFGL GDRACPGTAM AMIDLAAALA YWVEHWDIMH 04000401 DGDLAPRGWF SLRPQRARVR FRRRACYP169
Heme Docked
Heme Docked
PDBj
PDBj
CYP170 !!GS!!!
>CYP170A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MTVESVNPET RAPAAPGAPE LREPPVAGGG VPLLGHGWRL ARDPLAFMSQ 00500051 LRDHGDVVRI KLGPKTVYAV TNPELTGALA LNPDYHIAGP LWESLEGLLG 01000101 KEGVATANGP LHRRQRRTIQ PAFRLDAIPA YGPIMEEEAH ALTERWQPGK 01500151 TVDATSESFR VAVRVAARCL LRGQYMDERA ERLCVALATV FRGMYRRMVV 02000201 PLGPLYRLPL PANRRFNDAL ADLHLLVDEI IAERRASGQK PDDLLTALLE 02500251 AKDDNGDPIG EQEIHDQVVA ILTPGSETIA STIMWLLQAL ADHPEHADRI 03000301 RDEVEAVTGG RPVAFEDVRK LRHTGNVIVE AMRLRPAVWV LTRRAVAESE 03500351 LGGYRIPAGA DIIYSPYAIQ RDPKSYDDNL EFDPDRWLPE RAANVPKYAM 04000401 KPFSAGKRKC PSDHFSMAQL TLITAALATK YRFEQVAGSN DAVRVGITLR 04500451 PHDLLVRPVA RCYP170 !!GS!!!
Heme Docked
Heme Docked
CYP171
>CYP171A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 TAYLATHPDL VRTMLVSSGS GDFTRSKGAQ GASRFIGPIL VAVSGETHRR 00500051 QRRRMQPGFH RQRLESYVAT MAAAAQETAD SWSAGQVVDV EQAACDLSLA 01000101 MITKTLFFSD LGAKAEAALR KTGHDILKVA RLSALAPTLY EVLPTAGKRS 01500151 VGRTSATIRE AITAYRADGR DHGDLLSTML RATDAEGASM TDQEVHDEVM 02000201 GIAVAGIGGP AAITAWIFHE LGQNAEIESR LHAELDTVLG GRLPTHEDLP 02500251 RLPYTQNLVK EALRKYPGWV GSRRTVRPVR LGGHDLPADV EVMYSAYAIQ 03000301 RDPRWYPEPE RLDPGRWETK GSSRGVPKGA WVPFALGTYK CIGDNFALLE 03500351 TAVTVAVVAS HWRLHALPGD EVRPKTKATH VFPNRLRMIA EPRSVVRLEE 04000401 PAAMGACYP171
Heme Docked
Heme Docked
PDBj
PDBj
CYP172
>CYP172A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSECPFFPKP YKNKASTLLT FLLKRRSWLD GLYERSYKMQ TGYVKMPNFD 00500051 LYVINDTKEV KRMMVDEVRE FPKSAFLHEL LSPLLGESIF TTNGEVWKKQ 01000101 RELLRPSFEM TRINKVFNLM SEAVADMMDR FSKYPNHAVI EVDEAMTFIT 01500151 ADVIFRTIMS SKLDEEKGKK ILNAFVTFQE QSVHTAMRRM FRFPKWLSYV 02000201 LGDCKRAKAG DVIRQVLSDI IKPRYDMADN AEFEDILGSL LLVVDADTNK 02500251 RFSFEEILDQ VAMLFLAGHE TTASSLTWTL YLLSLYPKEQ EKAYEEITQV 03000301 LQGGVIEISH LRQFKYLTNI FKESLRLYPP VGFFAREAKK DTQVRDKLIK 03500351 KGSGVVIAPW LIHRHEEFWT NPHGFNPSRF EGEYKKDAYL PFGVGERICI 04000401 GQGFAMQEAI LILANILKTY KLELEEGFVP DVVGRLTVRS ANGMRIKFSK 04500451 RKCYP172
Heme Docked
Heme Docked
PDBj
PDBj
CYP173
>CYP173A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MDTQPAPFVP PAPKPRTSPP STLEMIRIVY RNPLELWGEP TYNEPWISAN 00500051 GVGGHLIVAN DPGLIRHVLV DNAKNYKMAT VRQKILRPIL RDGLLTAEGE 01000101 VWKRSRKAMA PVFTPRHIFG FAQPMLKRTK EFVTRYEEGG ASDIAHDMTL 01500151 LTYDILAETL FSGEIAGEPG SFANEIDRLF ETMGRVDPLD LLRAPDWLPR 02000201 LTRIRGRKTM AYFRKIVTDT VKMREEKFRR DPDAVPQDFL TLLLKAEGPD 02500251 GLTRSEVEDN IITFIGAGHE TTARALGWTL YCLAESPWER NRVEQEIDEV 03000301 LAREPDPTKW LDAMPLTRAA FDEALRLYPP APSINREPIE PEMWKDLYIP 03500351 RHAAVLVMPW VVHRHRKLWD RPDAFLPERF HPGNREKIDR FQYLPFGAGP 04000401 RVCIGASFAM QEAIIALAIL LSRFRFDTTA ETKPWPVQKL TTQPQGGLPM 04500451 QVTPRCYP173
Heme Docked
Heme Docked
PDBj
PDBj
CYP174
>CYP174A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MGPMETYVVT EPALVERLLV SDAAEFRKPE FQADAIDDLL GDGLLLSEGE 00500051 SWREQRGRAN PAFSMARVAG FDADIAAHAA DRVDDWPVGD TVDVEAAMTH 01000101 ITLDVILDVM LGVSLPEARV DAIGDALEPV GARFEPDPVR FAVPEWLPMP 01500151 DDREYAAAVA TLDDLVDDIV AAREGTASGG DGDDPMDLLS VLLRARDRGE 02000201 QSLDRLRDEV MTTLLAGHDT TALTLTYTWF LLSEHPDVEA RLHAELDGAL 02500251 DDGAQPTVAQ LQDLDYLEWV LQESMRLYPP VYNVFRTPIE PVELAGSEVP 03000301 AGAPIMLPQW AIHRSPDHWD DPEAFDPERW RPERRADRPR FAYFPFGGGP 03500351 RHCIGKQLAL LEAKLIVATV ASDYRLRYEG DTPLSFVPSL TIHPEQEMRM 04000401 RVEPRCYP174
Heme Docked
Heme Docked
PDBj
PDBj
CYP175
>CYP175A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MKRLSLREAW PYLKDLQQDP LAVLLAWGRA HPRLFLPLPR FPLALIFDPE 00500051 GVEGALLAEG TTKATFQYRA LSRLTGRGLL TDWGESWKEA RKALKDPFLP 01000101 KNVRGYREAM EEEARAFFGE WRGEERDLDH EMLALSLRLL GRALFGKPLS 01500151 PSLAEHALKA LDRIMAQTRS PLALLDLAAE ARFRKDRGAL YREAEALIVH 02000201 PPLSHLPRER ALSEAVTLLV AGHETVASAL TWSFLLLSHR PDWQKRVAES 02500251 EEAALAAFQE ALRLYPPAWI LTRRLERPLL LGEDRLPPGT TLVLSPYVTQ 03000301 RLHFPDGEAF RPERFLEERG TPSGRYFPFG LGQRLCLGRD FALLEGPIVL 03500351 RAFFRRFRLD PLPFPRVLAQ VTLRPEGGLP ARPREEVRACYP175
Heme Docked
Heme Docked
CYP176 !!!FL!!
>CYP176A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MTATVASTSL FTTADHYHTP LGPDGTPHAF FEALRDEAET TPIGWSEAYG 00500051 GHWVVAGYKE IQAVIQNTKA FSNKGVTFPR YETGEFELMM AGQDDPVHKK 01000101 YRQLVAKPFS PEATDLFTEQ LRQSTNDLID ARIELGEGDA ATWLANEIPA 01500151 RLTAILLGLP PEDGDTYRRW VWAITHVENP EEGAEIFAEL VAHARTLIAE 02000201 RRTNPGNDIM SRVIMSKIDG ESLSEDDLIG FFTILLLGGI DNTARFLSSV 02500251 FWRLAWDIEL RRRLIAHPEL IPNAVDELLR FYGPAMVGRL VTQEVTVGDI 03000301 TMKPGQTAML WFPIASRDRS AFDSPDNIVI ERTPNRHLSL GHGIHRCLGA 03500351 HLIRVEARVA ITEFLKRIPE FSLDPNKECE WLMGQVAGML HVPIIFPKGK 04000401 RLSECYP176 !!!FL!!
Heme Docked
Heme Docked
CYP177
>CYP177A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MTDVTVLFGT ETGNAEMVAD DIASALGEFD IEATVVGMED FDVADLAASG 00500051 TVVLVTSTYG EGELPATTQP FFDAMKAAEP DLTGLRFGAF GLGDSTYDTY 01000101 NNAIDILVGA VTDAGATQVG ATGRHDAASF QPADGPVAEW AKQFAEALSD 01500151 RTRRGGHEMT AASIDRELVP WSDPEFRNNP YPWYRRLQQD HPVHKLEDGT 02000201 YLVSRYADVS HFAKLPIMSV EPGWADAGPW AVASDTALGS DPPHHTVLRR 02500251 QTNKWFTPKL VDGWVRTTRE LVGDLLDGVE AGQVIEARRD LAVVPTHVTM 03000301 ARVLQLPEDD ADAVMEAMFE AMLMQSAEPA DGDVDRAAVA FGYLSARVAE 03500351 MLEDKRVNPG DGLADSLLDA ARAGEITESE AIATILVFYA VGHMAIGYLI 04000401 ASGIELFARR PEVFTAFRND ESARAAIINE MVRMDPPQLS FLRFPTEDVE 04500451 IGGVLIEAGS PIRFMIGAAN RDPEVFDDPD VFDHTRPPAA SRNLSFGLGP 05000501 HSCAGQIISR AEATTVFAVL AERYERIELA EEPTVAHNDF ARRYRKLPIV 05500551 LSCYP177
Heme Docked
Heme Docked
CYP178
>CYP178A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MIDLADLDLF TDGDPHEAWR VLRRDRPVHW NATGGDTASG VGPSGFWALT 00500051 RYQDVHDAYV DAGLFSSRWG TVMGGSHRRD ADSASGRMLI ASDDPQHRLM 01000101 RQQVHRAFLP ALMDRARRVV RDYVNAALDR VLKDGGGDFA TDVAPELPAG 01500151 LLAAMFGLER RDALHLLALT RSMIGFQDPR YHSDSTPPAV LVSSQVEIFD 02000201 VMMDLMETRR RAPSDDLVSI LLGASINGRR FTEDEVLYNC LNVAVGGNET 02500251 TPFTASAAVQ AFMDFPDQAQ RLLDDGGLLP TAVEEIFRWT STNAYVQRVA 03000301 TRDVELHGQL IRAGDPVTLW NASANRDEEK FPNPDRFDVR RTPNRHIAFG 03500351 VGVHRCIGMG AAQMEIALLL KEIVRRGITF EPAGPPARLR SNFMLGLTCL 04000401 PVHATVAQDA SCYP178
Heme Docked
Heme Docked
PDBj
PDBj
CYP179
>CYP179A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MDLELHGRLD ELQRDPYPHY ARARRFTALE HVPELDAWLV ARDADVREVL 00500051 RRPDDFSSAN ALRPDVMPAP AALAVLGGGF GGRPVVVTAD GARHQELRAP 01000101 IVRGLSPARV AAVLPYAAER ATALVDRFLS GAESGRVELM AAYARRLPGD 01500151 VIGRIVGLDP ADVPAVVYGG HRAEELLFRP LTEDEQVVAA QDVVAMQHLL 02000201 DAFVRDRRAD PREDLASEII ASVAPGDGEL TLDQRHDIVA HLQNLLLAGH 02500251 LTTTALIGTT VLNLLRHPRQ WELLCAEPER IPAAIEEAAR YDSALQGFRR 03000301 VTTRPVTLAG TELPAGASVF VAFGGANRDG GRHPRPDEFD ITRTPRRHLA 03500351 FGFGVHGCPG AQLAREQLRL TLEQLTRRLP GLRPADDRPV TMRPTLIHRS 04000401 PRSLHLVWCYP179
Heme Docked
Heme Docked
PDBj
PDBj
CYP180
>CYP180A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSVREQAPPV PDVFDPRRYA AGVPHAAYRT LRDHHPVARQ AEPEVLGWPA 00500051 GPGFWAVTRH ADVVRVLKDS TTYSSRFGAT QIRDPDPDDL PFIRDMMLNQ 01000101 DPPDHGRLRR LVSRAFTPRR VDRFESLARD RARTLLAAAL AGARAGDGSC 01500151 DLVATVTDDY ALLNLADLLG VPESDRGLLL HWTRRVIGYQ DPDEAGEPLL 02000201 DAAGKPVDPR SPGALRDMFE YARQLASYKR EHPADDIMTT LATDPELTGP 02500251 ELAMFFFLLT VAGNDTVRGA APGGLLALAE HPEAYARLRA RPQQLPSAVE 03000301 ELLRWHPPVL TFRRTAVRDT DLAGQRIRAG DKVVVFHASA NRDGRVFTAP 03500351 DRLDLSRSPN PHVSFGDGPH VCLGAHFARL QLRVLYAQTL RALPAPRVAG 04000401 PPGRLVSNFI NGIKSLPLQV ACYP180
Heme Docked
Heme Docked
PDBj
PDBj
CYP181 !!GA!!
>CYP181A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MLPAEYETLR ERGIGQVELP TGKLVWMVVR PEYARIVLSD PRFSSDKTDD 00500051 RFPKLTPNSL MKLRYCAPFM INLDGPEHLK KKKSIMDEFS PEGLARLLPR 01000101 LRVAVEEKID DMLRQPTKPV DLVKELAFPI AWQLQEMFLG IPAAELETMR 01500151 DNVWKLLLGT TTEAEEREAA DRLNGHAEEV LKEKAKHLGD DMMSRLIVQE 02000201 REKHGEVNWY ELAPLMLSNA QGIHNSVSTM ISLGVLTLLN HPEQRPTLLA 02500251 HPDRMTTAVD EMLRYFSVND GTPMRLATED MLIGDTLVKA GDGVAVPTLP 03000301 VNRDPSVCPY PHQLDIMREE PARHLAFGHG PHKCPADRLV PSLLEIVYTT 03500351 LFERVPTLAL AVPEAELTYK YHSIQAFGPA EMPVTWCYP181 !!GA!!
Heme Docked
Heme Docked
PDBj
PDBj
41% to CYP105
CYP182 !!FW!!_post Cys is short
>CYP182A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MHGRCGMRSG MEAQPYATAP AGSPRLESLR VEPLLTSEFD ADPAGVYERL 00500051 RRTYGPVAPV GLMGVPVWLV LDYHEVLEVL RDDSQWRRDI RYWRARAQGQ 01000101 LPRDWPLLAG YEVRQTMFLD GDEHHAARLT HHSALRPFQD GHSPQGWELR 01500151 AAVARYADEL IALLAAESGS AGYADLGAQY TRPLLLMVTG KLFGCPVGLG 02000201 DELVMDLWRM LDGGPDAGPA TDRAAAVMTR LAAHRRQRPG DDLTSYLLLA 02500251 DPGMTDEQLG RELLMNAVYL NDITGNMVMN TLLEVLRGNA TVRRSVSDGH 03000301 LGETFHRVAL VNPPVANMCF RFAAGDVRLG AFWIRAGDVV SPSAAAAHQD 03500351 LLTIGTSPLG DATASTRAHL GWGAGQHQCP GAARELAGMI VTTAVGRIFD 04000401 HFTKAELTLP ADQLPWRSGP VVRGLRLLPV RYELRGTPSE SHPVPPPRHD 04500451 GEAPDTAPTA DHRSRGLLSA LRRLMTGTGR AGCYP182 !!FW!!_post Cys is short
Heme Docked
Heme Docked
PDBj
PDBj
CYP183
>CYP183A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSQHTFVAGT APGAVPVVGH AWQMMRRPLH FMSSLSAHGD LVKIRIGPTS 00500051 AYVPCHPELL RQVLTNDRVF DKGGVFYDRA RDIAGNGLVT CPYRDHRRQR 01000101 RLMQSAFQRT QLERYSTAMR AEIDATAARW HDGTVIDAFP ELYGMALRTV 01500151 ARTLYSTPVT EELAQRVEQA FDTVLNGLFR QMFLPHSLRR LPTPANLRYR 02000201 NNLRFLHDTV QDLITEYRRD DTQRDDLLSA LLASRDEDGG RLGDTEIHDQ 02500251 VITVMAAGTE TVAGTLTWIF HLLSRHPEIE ARLYEEIDTV LDGKPPHWDD 03000301 LPSLSLTDRI ITEALRMYPP AWIFTRLTAS DVDLAGVRLP EGTTIVFSPS 03500351 SVQRHSEAYD DASRFDPDRW LPDRTSAVAR QAFTAFGTGA RKCIGDLFAR 04000401 TEATLALATM LSQWRVTVEP DADVRPVALA TVYHPRRLRL RLTARTPGQCYP183
Heme Docked
Heme Docked
PDBj
PDBj
37% to CYP170A1
CYP184
>CYP184A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MAAVTAAGAA QAPIVAGHPL LGSMNDLLND PLATYLRARR DHGDVVRFRA 00500051 GPPGLRADIY AVFSAEGAQQ VLATESGNFR KDNVFYGELR DSVGNGLLTS 01000101 QDATYLRQRR LVQPLFTRRR VDGYAGQVAD EAAGLAEAWR GIPGGGVELV 01500151 GEMHRFALRV VGRILFGTDM ETTFEVIERT LPLLQEYALK RGLAPVRTPR 02000201 TWPTPANRRA ARTQAELFAL CDGIIDSRRN RKNEGDGGEE SGEDLVTLLV 02500251 RAGNAEDGSL DAAELREQVL IFLLAGHETT ATALAFALHL LARHPEQQRR 03000301 VRDEADRVLG GPGGRAPTAA DMEALPYLTM VLKEAMRLYP SAPVIGRRAV 03500351 ADAEVDGVRI PAGADLFVSP WVTHRHPDYW PDPERFDPER FTPEAEAGRP 04000401 RYAWFPFGGG PRACIGQHLS MLESVLGLAV LIREFEFEAV GEEEVPLGAG 04500451 ITLLAKGPAR CRVIPRSSGP RSSCYP184
Heme Docked
Heme Docked
PDBj
PDBj
CYP185
>CYP185A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MRADTRFMVE TASPPLTELP LAPRNTLPCR EQIRCLRSFI DGMQRLRDVG 00500051 GPVTRIVLGP RWLVPPALLV TSPQGAHDVL SLPDAVADRG GSRNMRQLQR 01000101 LMGGNLLDLP HDRWLPRRRT LQPLFTKKHV PRFAGHMAAA AQSVAVSWAD 01500151 GATVDLDRAC RALTLRALGR SVFGVDLDQR AEDVGPALRT SLSWVADRAS 02000201 RPVNLPQWVP TRGQRKARAG NATLHRLAAE ILADVRADPD RDAPLVRALL 02500251 EARDPETGRG LTDDQICDEL VLFMLAGHDT TSTTLCYSLW ALGHHPDIQE 03000301 RVYAEVAALG DRELTTDDVP QLTYTMRVLH EALRLCPPGS GTMRMLNEEM 03500351 TVDGYRVEAG TVAIVNFYAM HRSPTLWDAP ERFDPDRFSP ERSAGRNRWQ 04000401 YLPFGGGPRS CIGDHFAMLE ATLALATVIR AVSVESQNTD LPVETPFTVI 04500451 AAAPVPARVT RRCYP185
Heme Docked
Heme Docked
PDBj
PDBj
CYP186
>CYP186A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSDGGHQLRG AQALATLVDL GFPAIASGVI ARRPPVLGLL ERMQADERAG 00500051 RRMHRLRSEF GRGPVELVIP GRRIVVVTDP EDVAAVLVQA PEPFHPANRE 01000101 KRKALQWFQP HGVLISQGPI REQRRTVNEA ALDSGAAMHR LAESFAAKVA 01500151 AEADTLVART LPGQRLDADE FMTAWWRLVR RLTLGERARD DHAITDQLAR 02000201 LRRAGNWSFL SLPHYRARSR FLSHLYRYAE DPEPGTLVGA LADVPAGGAV 02500251 DPVGQIPQWL FAFDAAGMAL LRALAVLATH PLQRDRALED AGEPNRPLLR 03000301 PYLRGCLLES VRLWPTTPAI LRDTTEDTHW REGAERFTVA KGAGLLIVAP 03500351 AFHRDDQVLP FAHDFVPEIW IDGRAQLYPQ LVPFSAGPAE CPGRNLVLFT 04000401 TSTLAANLLN RLHFDVRSEP RPVPGEPLPM TFNHAGIEFS LRPARRAVTA 04500451 ATVDPATCYP186
Heme Docked
Heme Docked
PDBj
PDBj
CYP187
>CYP187A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MDSRIRDDPA VDTAALLRDP YPIFARYRAQ AGVFRGSVMD WSKTPKELMP 00500051 EHQYAAMSFD AVNTVFRDGK TFNSKIYDST IGLFIGPSIL AMEGKTHRDH 01000101 RNLVSAAFKS KSLARWEPEI ARPICEALVD EFVDTGSADL VRDYTFEFPT 01500151 RVISKLLGLP EEDLPWFRRR AVELISYSVK YKRAFEASAA LKDYFLDQIE 02000201 RRRSRPTEDI IGDLVTAEID GEKLTDEAIY SFLRLLLPAG LETTYRSSGN 02500251 LLYLLLTHPD QFAAVQNDHD LIGAAIEEGL RYETPLTTVQ RSATKDTELE 03000301 GVQIPAGAVI DVCIGSANRD ENRWERPEEF DIFRKRIPHI TFAAGEHTCM 03500351 GLHLARMETR VAMETLLNRV TDLRLIADDD PHIFGQPFRS PTAIPVTFRP 04000401 AGCYP187
Heme Docked
Heme Docked
PDBj
PDBj
CYP188
>CYP188A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSIQDVTTDD DREKITYHFD RHTPEYRLQF EKITEEMHSR CPVAWTETYD 00500051 GHWVAAGSNE VFELARCPVV SNHHDISGET PFQGITIPKA SRATVVRGGI 01000101 LEMDEPEHSA YRGALNPYLS PAAIKRWEPF VDEITRAAID EHISSGRIDF 01500151 VEHLANVVPA VFTLAMMGIE LKKWNVYSEP THASVYTPEH APEREKINEQ 02000201 HREMGIDLIN NMMEIRQNPR PGLVNALLQL RIDGEPAPDM EILGNLGLII 02500251 GGGFDTTTAL TAHALEWLGE HPDERERLSR ERDTLLNPAT EEFLRFFTPA 03000301 PGDGRTFAED AEVAGYKFKQ YERLWLSWAM ANRDPSVFDK PNEVILDRKG 03500351 NRHFSFGIGV HRCVGSNVAR TVFKSMLTAV LDRMPDYVCD PEGTVHYDTI 04000401 GVIQGMRNLP ATFTPSRPLG PGLDETLEKL QRICNEEELA RPITERKERA 04500451 VIDCYP188
Heme Docked
Heme Docked
PDBj
PDBj
CYP189
>CYP189A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MPPFDDGVPM AQPSTSATPD LYYDPYSVQL NMEPHEVFAR IREEAPLYYN 00500051 EQHDFYALSR YHDVNKAVID HETFISGRGA LLELIKSGME IPPGTLIFED 01000101 PPIHNIHRNL LSRMFTPRKV LALEPQIREF TTRCLDAVAG SDTFDFVNDL 01500151 GEQMPMRVIG MLLGIPEDRQ RAITDHGEET LQGTTVDSLA TGEVFAEFID 02000201 WRADNPSDDI MTDLLNAEFE DETGTVRKLR RDELLLYLTV IATAGSETTT 02500251 RALGWAGKTL ADHPDQRRDL VENPALIPQA IEELLRWEPP ALQIARYVTR 03000301 DVEYYGKTVP AGSAMLMLVG AANRDHRRFP PNGDVFDIHR EQFSHMTFGA 03500351 GTHFCMGNAL ARLELRVALE EILKRFPEWE VDWDNARPSE TAAVRGWAAM 04000401 PTFVRCYP189
Heme Docked
Heme Docked
PDBj
PDBj
CYP190 !!!FL!!!
>CYP190A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MTTPQMIFDP FSEQYFENPF DIYRQMRDDA PLYYDSEQDF YALSRHEDVA 00500051 AALKDHEAFS SSRGCDLAMV KGDEPPQKSI IFMDPPEHRH MRSLLNKAFT 01000101 PRAVQAQRDT VVEQVEHYLG QIDSDEFDVV QDFSGPFPVE VITRMAGVEP 01500151 EYRQQVRHWI DTSLSREPGQ VAYSEAGMKA NIDTAMYYYS LVQKRRENPQ 02000201 DDMISRLIAA EIPGENGEMR RLDDVEITGF ATLLGGAGAE TVTKLIGTAM 02500251 VTFAKFPDQW QKLLDDRSKV PAAVEELLRY EGPVQYNVRY TLKEARVPSG 03000301 TIPAGKPVFL LKASANRDER AWTDPDVFDI DRDRTEAQNL GLGYGIHSCL 03500351 GAALARLEST IALERLLDFM PRYEVKWDGL QRVHMQNVAG YSHVPVKVLR 0400CYP190 !!!FL!!!
Heme Docked
Heme Docked
PDBj
PDBj
CYP191
>CYP191A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MTTTVKPPVT EAVTGEFSYD PFDPAVMADP TPYYRVLREK YPLYHIEKWD 00500051 TWALSRFSDI WEVLEVNDGT FVASEGTLPA ATVLAEHNDG AVPDPPWHPM 01000101 PFHANFDTPI YDSVRRCTSP QFRPRSVTKL ADRIRTLANE RLDELLPRGQ 01500151 FDLTQDYGGI VAASVVCELV GLPVDLAADV LATVNAGSLA EPGSGVEVAN 02000201 ARPGYLEYLT PVVQRRRAGE GRELPIVDNL LQYRLPDGSA FSDLEAAVQM 02500251 LGVFIGGTET VPKIVAHGLW ELTRHPEQLA AVRTDLDANV PIAREEMIRF 03000301 CAPAQWFART VRKPFTLHGT TLQPGQRVIT LLASAGRDER EYPDPDSFIW 03500351 DRRIERLLAF GRGQHFCLGV HLARLEITIM VTEWLKRVGE FRVDERAARR 04000401 PPSSFQWGWN NVPVEVCYP191
Heme Docked
Heme Docked
PDBj
PDBj
CYP192
>CYP192A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MDADVRSAPL IPPAPKVHPR QLGGSFVGEL RIALEMSRNL MGAWCEEDFD 00500051 NLFTPYVFMG QPGMVVSDPA AARRILSSPN YVRPVKAARS VRPIAGDGLL 01000101 LSEGETWRRQ RKSLAPVFTP MAVEGLLPHF VAAGASLAEA LSGHARADLS 01500151 EAFHHATLDA VLSALFSRRA DAQGDQLAYM VRRYMEGPAH FNLMDFVSRG 02000201 ADDLTFLDVE RRRQGAAWFQ AVEHLIAQRQ AHPHAEARDL LDRLLAARDE 02500251 DGAPLSNQEI RDQCGTMLVA GFETTSRLLF WATYLLALDP ATQDRLRAEV 03000301 LAAPAAAVRT LDDLQAWPLM RSVLFETLRL YPTAPLLARE AIGPDTVMGH 03500351 AVVPGQIITI SPWLIHRHRK LWDAPTAFVP DRFIDQPHPW GIEAFLPFGA 04000401 GPRVCIGASF ALAEAQIVLA SLLERFEIGL VSDRPVIPIA SITLGPDHAP 04500451 AFTLTPVSCYP192
Heme Docked
Heme Docked
PDBj
PDBj
CYP193
>CYP193A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MARGCASRCS RPVSDASPAP RAGTLSGARL ECRLCRFMAL DERCLCVCRC 00500051 PLLWVMRTRY RARTPCPNRW GQTAAPERAS LAGHSRETAL STAPRIDIDP 01000101 AAFWADPYPM LANMRKEAPI AFVPQLGSTL LTSRDDISIS EKQIDVFSSH 01500151 QPAGLMNRLM GHNMMRKDGE AHQVERRAMF PTVSPKTVKG YWTALFQAHA 02000201 DRIIDAIEPG RIDFMRDFAL PFSGECLKSI TGLTNIGFAE MDAWSQGMIE 02500251 GIANYVGDPA VEARCHAATS GIDAAIDDML PVMRKNPDQS ILGVLLASGM 03000301 PMESVRANVK LAISGGQNEP RKAIAGTVWA LMTHPEQLDL VRRGEVTWLQ 03500351 AFEEYARWIS PIGMSPRRIA KPWSIRDVAF ELDERVFLMF GSANRDEKHF 04000401 ERADQFDVRR DTSKSVAFGA GPHFCAGAWA SRAMIADVAL PTLFARAGRI 04500451 EIADDEPVRI GGWAFRGLQN LPARWLHCYP193
Heme Docked
Heme Docked
PDBj
PDBj
39% to CYP1232A24
CYP194
>CYP194A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSDVSEPVAH PPVTDWVNDF DHTDPQWTDD PFPIWDELRA ASPVVHTERF 00500051 LGCYMPTTYE AVREIANDTE HFSSRRIIVR DVRPEIARNA APPITSDPPV 01000101 HKPAKQLLLP PFTPDAMKKL EPRVRTICNE LIDGFISDGK VDAAARYSKY 01500151 IPVRAIAHML GIPESDSDLF VNWIHMILEL GIKDETMLLQ AVQEMSAYFR 02000201 THIEERRSRP TDDLISYLMN AKDKEGQPLE ESHVLGSLRL LLIAGIDTTW 02500251 SAIGSSLWHL ARTPADRERL IAEPGLIPIA VEELLRAYSP VTMAREVVKE 03000301 TTISGCPVKA GNMVLLSFPA ANRDPKMFPD ADKVVIDRRE NRHAAFGLGI 03500351 HRCVGSNLAR MEMQVALEEW LKRIPDFRLD PAGTVTWSQG TVRGPRQLPF 04000401 LLGKAMCYP194
Heme Docked
Heme Docked
PDBj
PDBj
CYP195
>CYP195A1 C_1 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MNADAKELAA SFDLEKLTPE FYDNPYPTYR ALRENEPVKR LPNGTVFLTR 00500051 YDDLVTTYKN TKSFSSDKKR EFAPKYGNTP LYEHHTTSLV FNDPPAHTRV 01000101 RRLIMGALSP RAIAGMEADL IKLVDGLLDA IAAKGSCELI EDFAASIPIE 01500151 VIGNLLDVPH DERTPLRDWS LAILGALEPV VSPEAAARGN KAVKDFLSYL 02000201 ETLVARRRGK PGNPERDVLT RLIQGEGNGE ENGERLTEKE LLHNCIFLLN 02500251 AGHETTTNLI GNGLVALDRH PDQKQRLIDH PDMIKTAVEE MLRYESSNQL 03000301 GNRMTTERVE LGGVMLDAGT SVTLCIGAAN RDPAQFPDPE SFDIARTPNR 03500351 HLAFATGAHQ CAGMALARLE VAIAISRFLA RFPNYAVNGR PVRGGRVRFR 04000401 GFLSVPCAIG CYP195
Heme Docked
Heme Docked
PDBj
PDBj
CYP196
>CYP196A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MLPRSAGAGR NKVAVARCPF GQPTGALVMS MQNVAAPALQ FTAPRRNELT 00500051 HIPGDEGWPV IGKTFQVLAD PKGHIEANGA KYGPVYRTHV FGETNVVLLG 01000101 PEANELVMFD QQKLFSSTHG WNKVLGLLFP RGLMLLDFDE HRLHRKALSV 01500151 AFKSGPMKSY LSDLDRGISA RVAQWKAKPG EMQLYPAMKQ LTLDLAAASF 02000201 LGADIGPEVD EINRAFVDMV AAAVAPIRRP LPGTQMARGV AGRKRIVAYF 02500251 RQQIPLRRGN HGGDDLFSQL CRATHEDGAL LSEQDIIDHM SFLMMAAHDT 03000301 LTSSLTSFIG ELAANPDWQD RLRAEVLALG LAPGAPSSFD DLEKMPLSEM 03500351 AFKEALRIKP PVPSMPRRAM RDFTFKGFRI PAGTAVGVNP LYTHHMKDIW 04000401 PEPDRFDPLR FTEEAQRNRH RFAWVPFGGG AHMCLGLHFA YMQAKCFARH 04500451 FLQNIEVSLA PGYKPDWQMW PIPKPRDGLK VRVKAVCYP196
Heme Docked
Heme Docked
PDBj
PDBj
CYP197
>CYP197A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MPTNTMPTGP KGNPVLGNTI EFGKDPLQFI TRCSQEYGEI VRLRFERERD 00500051 TFLLNDPKHI QYVFMNKGGE FSKGYQQDPI MGLVFGNGLL TSEGSFWLRQ 01000101 RRLSQPAFHP KRIADYADTM VGYCERMLNT WMDNDTRDIN DEMMQLTMAI 01500151 ATKTLFDLDL HKGDTQEASR SLDTVMTAFN EQMTNVFRHV LHLIGLGKLV 02000201 PPVSRELREA VESLDKMIYS IIEERRKHPG DRGDLLSMLI STYDEDDGSY 02500251 MTDRQLRDEI ITLFLAGHET TANTLSWAFY LLSQHPHVEE KLYQEVSQVL 03000301 GNRPATLEDM PKLSYAEHVI KETLRVQPTV WLISRRAEKD VTLGDYHISA 03500351 GSEIMISQWG MHRNPRYFND PLTFLPERWD NNDNKPSKYV YFPFGGGPRV 04000401 CIGERFALME ATLIMATIVR EFRMELVDEL PIKMEPSITL RPKHGVTMKL 04500451 RKRCYP197
Heme Docked
Heme Docked
PDBj
PDBj
CYP198
>CYP198A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MRRPAFPASV MNSSGAVWQH KRRTLMPAFR AALVRESAMQ ASAATRSLLH 00500051 ELGDSCATQD MRTLMTGLCA QLGAGFLLGD SANAADLLRM LPMVDAISKQ 01000101 TRRQSLAPTW WPSSGRRRLR RLRADIDMAL DRILMQSTQR PPRAASVLAL 01500151 LLAETARDDG DWCRDEAAAI LMSALEPMSA ALTWTLLLLA QHPHIAQEVA 02000201 QEASALDGAD VASGTSLLDR LPQSRACVKE SMRLYPPAWI TARIAQRDAT 02500251 LNGFHVPRGT QLLVSAWVVH RDGRHFPDPE IFLPARWLDD SATHSLTRYS 03000301 YFPFGGGPRS CIGCMLALTQ MTIVIATVLH ACSLHLAPDA RPSPFPALVL 03500351 RPMDVRIALR PRVIRSVVPS RAHASPVRLA SVTPNDCYP198
Heme Docked
Heme Docked
PDBj
PDBj
CYP199
>CYP199A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSAPGSAASG VPHLDVDPFD MNFFADPYAA HELLREAGPV VYLDKWNVYG 00500051 VARYAEVHAV LNDPATFCSS RGVGLSDFKK ETPWRPPSLI LEADPPAHTR 01000101 TRAVLSKVLS PTVMKQVRDR FAAAAEERVD ALIEKRSFDA IADLAEAYPL 01500151 SIFPDALGLK SEGREHLIPY ASVVFNAFGP PNQLRQEAIA RSTPHQAYVA 02000201 EQCQRENLAP GGFGACIHAQ VDEGAITASE APLLVRSLLS AGLDTTVNGI 02500251 GAAVYCLARF PEQWQRLRGD LSLARSAFEE AVRFESPVQT FFRTTTREVE 03000301 LSGATIGEGE KVLMFLAAAN RDPRRWDKPD SYDVTRRSSG HVGFGSGIHM 03500351 CVGQLVARLE GEVMLTALAR RIAKIEITGE PKRRFNNTLR GLDGLPVTIT 04000401 PACYP199
Heme Docked
Heme Docked
CYP200
>CYP200A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MAPRLDFTSE AFFRDPPAAI AALRASGPVV ATRFPLVGDV WITTTHDATA 00500051 EVLKDGTTFT LRKEDGKVAG LRWWMPKLVT TIANNMLTMD EPDHTRLRSI 01000101 VDEAFRRRAI VAMEPRIRAI ADGLANDLFA DGSPADLVQC YARILPVSVI 01500151 CELLGLPAAD RPRFIAWANK MSSLTNVVSF FRLLFAFRKM RAYLERQLQI 02000201 ARVRGGEGLI AELVQVELEG GQITPDEMVS MVFLLLAAGS ETTTHLISGS 02500251 VYELLRNPAL RDWLEEDWSR ISLAVEEFLR FVSPVQFSKP RYLRRDVELA 03000301 GVRLKKGDRV MVMLAAANMD PAVHDRPERL DLTRKPNRHM SFGTGIHFCL 03500351 GHQLARIEAT CALQALLARW PKLELAVDPA QIHWRKRPGM RAIARLPVVA 04000401 GGNRRPSRGA AAEPLLADCYP200
Heme Docked
Heme Docked
PDBj
PDBj
42% to CYP107BR1