CYPSD - Bacreria1051-1200

Reference

Cytochrome P450 HomepageDavid R. Nelson, (2009) The Cytochrome P450 Homepage. Human Genomics 4, 59-65.AlphafoldJohn Jumper, Richard Evans, Alexander Pritzel, et al. - Highly accurate protein structure prediction with AlphaFold. Nature, 1–11, doi: 10.1038/s41586-021-03819-2 (2021)ColabfoldMirdita M, Ovchinnikov S and Steinegger M. ColabFold - Making protein folding accessible to all. bioRxiv, doi: 10.1101/2021.08.15.456425 (2021)Localcolabfoldhttps://github.com/YoshitakaMo/localcolabfold

CYP101-CYP299, CYP1001-CYP1050Cytochrome P450 HomepageComprehensive Bacterial P450sDavid R. Nelson, (2009) The Cytochrome P450 Homepage. Human Genomics 4, 59-65.https://drnelson.uthsc.edu/comprehensive-bacterial-p450s/
CYP1041, CYP1042, CYP1043, CYP1044, CYP1047, CYP1051-Fanele Cabangile Mnguni, David R. Nelson, and Khajamohiddin Syed et al.,More P450s Are Involved in Secondary Metabolite Biosynthesis in Streptomyces Compared to Bacillus, Cyanobacteria, and MycobacteriumInt. J. Mol. Sci. 2020, 21(13), 4814; https://doi.org/10.3390/ijms21134814
CYP1067, CYP1100, CYP1119-CYP1134Mohammad Parvez, David R Nelson, Khajamohiddin Syed et al.,Molecular evolutionary dynamics of cytochrome P450 monooxygenases across kingdoms: Special focus on mycobacterial P450s Sci. Rep. 6, 33099; doi: 10.1038/srep33099 (2016).
CYP1094, CYP1136, CYP1146, CYP1156, CYP1158-1159, CYP1177, CYP1184, CYP1185CYP1137, CYP1320, CYP1136, CYP1719, CYP1762, CYP1851, CYP1912, CYP1976, CYP2029, CYP2287, CYP2337, CYP2725Makhosazana Jabulile Khumalo, David R Nelson, Khajamohiddin Syed et al.,Comprehensive analyses of cytochrome P450 monooxygenases and secondary metabolite biosynthetic gene clusters in CyanobacteriaInt J Mol Sci . 2020, 21(2), 656. doi: 10.3390/ijms21020656.

D. R. Nelson's

Bacteria_1

Bacteria_2

Bacteria_3

https://twitter.com/P450nelson/status/1501396401317883904

Method

Localcolabfold (model1_ptm, recycle=6 or CaRMSD < 0.4, centerd and rotated around proximal Cys)runner_P450align.py -f CYPs/CYPXXXA1.fasta -nm 5 -mr 6 -alirunner_P450align.py -f CYPs/CYPXXXA1.fasta -nm 5 -mr 6 -ali -upMaestro (Protein preparation Wizard)proPKa pH 7.0, save as pdbHeme was extract from proximal-ligand-aligned crystal structure of CYP101A1-CYP150A1Heme was added hydrogen using maestro builder, save as mol2ES_scoreMaestro output

runner_P450.py

align_P450.py

CYP1051

>CYP1051A1 (2545384930)Streptomyces rimosus rimosus ATCC 10970---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----
>CYP1051F1 (2545384930)Streptomyces rimosus rimosus ATCC 10970---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MASRTRIDTP GRNEHRLHTV PLRHVLGGLR AGGPLGLMER TGRRSQGALT 00500051 RLELGAFRPF LVTHPDHLRH VLRDHGANYR RGTAMWKAMG RLTGMGIAGE 01000101 GPQWRASREL WCRGLSGGAH VFADGTADAV AGAVADLERR VAAGATVDAL 01500151 TEMTRVVLRV VNPAFFGSRI PQGECDRLAA AVAVAFDSLL WRMALPFVPL 02000201 AVPLPGDRAF TRATRTVNGI LLPLIRRARH AHHRGPDLMS TLLDGADADG 02500251 RALGDAHVAQ DIVAMFVAGS ESSALTLTWA WVALAGHADI AAEVRREADA 03000301 VLGGGPPRPE HARRLVFTRR VLAEVCRLYA MAWAVPRTAV AEDVIGGVTV 03500351 PAGATLVLSP YLTHRLPAFW ERPLRFDPGR FTDERVRGRH PLAYLPFGDG 04000401 PHQCVGQSFF FQQAALVVAT MMSRFRIAVP TPAEPRAAVA LRPRSRVDLA 04500451 LTPRG

MMSeqs2

Alphafold2

.fasta

Heme Docked

PDBj

CYP1052

>CYP1052A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----

Alphafold2

.fasta

Heme Docked

PDBj

CYP1053

>CYP1053A1 (2563677243)Streptomyces rapamycinicus ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MTTADPALDH FDGTLSATDV RRAHADMREA CPVVHSDRHG GFDFLTRYAD 00500051 VRAALNGTEA FSSADGVRIP PSGVLPPIPA LEFDEPEHSE WRRVLDGPLT 01000101 PRAVRGLESV ITEVVDLLID DFATVGKADL VGQLTEPLPA IVIGRMIGLD 01500151 QAEAVRARAV AAALFAAMGS EEFPARFTEF SEHTQRWLAD RRENPRDDML 02000201 TELASGVVQG KEIDEAAATG LMLAYIVGGH HSTGSALGGL IRNVLTVPGL 02500251 RDDLLTDRRG LPRVIEESLR LTTPLQLFAR TLRCPVQFGD RELAAGGRVL 03000301 LDLAAANRDP REFSDPETFD RGRTRNRHLS FGAGPHVCQG QHLARAELRI 03500351 ALGRLLDRLP DLSLDGEPVE SGLVGGSLMT HFALPVAFTP EISA

Alphafold2

.fasta

Heme Docked

PDBj

CYP1054

>CYP1054A1 (2563677627)Streptomyces rapamycinicus ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSLLPPGSRQ PALLQTMRMR DPVHYFASLR RRYGPVFRMQ LIGFPPQVVV 00500051 STAELAAEIY STDGDGNRAG ALRAGYVPWL GDYSLFTNDG EPWWRHRKLL 01000101 SPALHGRSIA NYPDLIAEIA AEDIRTWPLG RPFALQEHMQ AITLEVTLRL 01500151 VFGIRDVTQL ARLRALLLTL SKASGSPLLF LMPARLRAWA EKSPLAMRVP 02000201 VLPTTRTMKA SAAVDEILFA ELARRRDEED SGATDVLGRL LQARDDQGRS 02500251 MSDQEIRDEL LTLLEAGLET TATGLSWAFE RLMRAPDVLR RLLEELERGE 03000301 DDSYLEAVVK EVLRLRPVIT GSGRLLDKPL RLGGYEIPAG WVAIPMFSLI 03500351 HQDSEAYPDP EEFRPERFLG EGAQAAQKSF LPFGGGRRYC VGAQLAMMEL 04000401 KVIIREVLRR VELTAADPAP EAQRMWHVTL VPGKRAVAVA REQPLNRASL 04500451 SEEPRCPVHP APSE

Alphafold2

.fasta

Heme Docked

PDBj

CYP1055

>CYP1055A1 (648749547)Streptomyces violaceusniger---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSAVLFRSWT KTAGTHWPAI TRVADQQGTE HLVVTQHALV RQVLTDQLTY 00500051 RPDNALDAVT PIPVAALRVL AGHRFRLPPT LANNGGVSHP AIRALVADAL 01000101 HPAKVAAQRP WLTGLVAERV AAIRRTLDSG GSTDLHAELN ADLPLLVLAR 01500151 LVELPDAPVS AVKQFARAAL ELFWAPLDAD RQLALADEVG RFHQVLREFA 02000201 DTGGGLAAAL RATGHPPDVL VGALFFLLVA GQETTSQFLT LLLHRLADEP 02500251 TVRAALRADS VSVADVVEEG LRLEPPIVTW RRVAAVDSTL GGSTVAAGTS 03000301 VLLWLARAGR DPAVVPAPDE FRPGQRGSRR HLAFGAGAHR CLGDQLARME 03500351 AAVVVEQVTP LLDGVTVVRP PWYPDNLTFR MPDAFVVRR

Alphafold2

.fasta

Heme Docked

PDBj

CYP1056

>CYP1056A1 (2720607090)Streptomyces venezuelae---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MRSIAFLAPD FLANPWPRYA RFRAEQPVWW SDEIRMFCVF RHRDIRACLT 00500051 GADYTVEYPF RVSRQVFGET LLDLDGPRHQ RLRRPLAGLL LGQRDNIAFR 01000101 AAAGERARTA VAALPADTVL DMVAGPARAV PLTATATFLG VPAERHDWLL 01500151 HTVEYLVGHL DGSSGDFGRA SALRAELEEY LLGLITSGAP PRSMLGEVHG 02000201 WVRDGEITAR EAVGLATLTL AAGFETSTGL ISNTLHCLAR HPGHAAAAAA 02500251 DPGRLRAFVK ETLRWEPPQH DTVRFARRDT TLAGVPVPAG SALKLMLASG 03000301 NRDAEVFEHA EEFRPERSTH GSLTFGHGAH SCLGTHIALD VAEAFVGALL 03500351 ARFPGLRAVD DPLPPITGST FRRPQALRMR LGPKGES

Alphafold2

.fasta

Heme Docked

PDBj

CYP1057

>CYP1057A1 (2562425221)Streptomyces sp. PAMC 26508 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSGPESIHLE PADLDGQAEA ALRALREHGA VVPVDLPEGL RVWVITRYQE 00500051 GRTALTDPRF VKDMRRLQEP GHGFAGQRYA EDVLAVEGRH VLNSDGTEHA 01000101 RLRSAVASHF TAHASAGHEA EVRQIAATLS EKVASQERAD LMSTYAQPLP 01500151 ELVIGRIIGV PDDIMPVIGR LSRQLSSRDN PATAPMRRAY SDLVDLVRDL 02000201 TTHPATDPRT VISGLQEAVA RGDLSRREAA STLMVLFAAG ISTTATGLGH 02500251 AAATLMCTHA ALRPLLGSAS AASLVDEILR HHPPIQFTSW RFAALDVPVG 03000301 STTIPAGSLV LILLASANRD PAAFPAADEL VPDRQATPAP LTFGRGPHYC 03500351 IGAHLARLEI QIGLQTLFER LPDLQLINSH EHTTWRGLLL DRTITSLPVL 04000401 TQAIP

Alphafold2

.fasta

Heme Docked

PDBj

CYP1058

>CYP1058A1 (2562412170)Streptomyces davawensis---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MRSGYATESR GLAWLHQCLA EERAESGLAF NPLRDAFQRA PEEVYAELRH 00500051 RSPVHHSRLL DCWVVTRYAD VARVLRDHTV FRSSPDATTQ DLVDPYVTLD 01000101 PGRPSLFMLD PPDHTRLRGA VREAFAPEAL RRLTPRLEEC VRHTVRALGR 01500151 PGERVDLVPR FATLVPLRVF DLITGLDLHS EDRVTDWVSD VVRGLEPIAT 02000201 ARTAEQALTA YRALGACLDE RRAAPAREGT LHFTLARDVE AGRLSDAEAR 02500251 QLLMFLILAG TKTVSDFLAG AAAELTALPP GAPGRRRVDD ALVDDLIVRT 03000301 SPVQIVARTA ASPAVVGGRS VGVGDRVLLV LASANRDTGR EGRDLAFGGG 03500351 IHRCVGAQLA RLEGRSALSC LLETYPEVRS AEAVPSRRCV TLRSWDRVIV 0400

Alphafold2

.fasta

Heme Docked

PDBj

CYP1059

>CYP1059A1 (2555756066)Streptomyces collinus---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSDGKILFRG TLDERTVSRS SAEPAATVVP MRMGTAGVGL LVNDHGEATR 00500051 ILSDVETYGS AGELMASVFD EPAESHPDAA SEAVFAVNQT DGEEHRRVRR 01000101 ALRRVIDARV RDVSDQLIQD VQQSIESALA LGRLDAVASI GVPVADSVMS 01500151 RLLGLDANLV SALRNAVYQG YPVRELDATL VDWVRDRRAH PADDLVSDLM 02000201 AELPSLDDRQ VAANTRLLAL SGVEVLAALI TNGILCLAQD PGTQSLVRED 02500251 ETLLPGLVHE VQRYASPIAR GIYRMTKRSS VIGKYSVPAG TLLVIGVDVC 03000301 NRDTSAFPDA HRFDPTRGRD FEHLTFGRGR HSCLGIPVTR LIAMQALRMF 03500351 LSGTTRFGLT VEPSELRFHE TMVMNGLVEL PIWVECAD

Alphafold2

.fasta

Heme Docked

PDBj

CYP1060

>CYP1060A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MLRRAEDFPK APSPLFPPLK GSNRAPTAEE RAHAHAARMR GLRAQAVAAR 00500051 VGEIAPGAAR FAEQWPTGRD VEVLPAARHA LAEIGVGYLF SEDAPALLPF 01000101 AARLFLAREV LARPSRWEWP RWVPTPARRF RTRQQAAFTE ALRPIVRRRR 01500151 ASGRLGDDVL GQMLQPSARY GPLPEGAVLD TLPGITVATF EAPTRAAGWI 02000201 LLHLARHPWA ADRVAAEAAS LPADPAATTS AHLDDLRYTQ ALVREVLRLH 02500251 PPSWLLTRQT ARQTELADYT INAGSTVLVC PYTAHRDARE HAEPDEFRPE 03000301 RWLDDSGSPA DPGAFLSFGT GPHGCEGAAL AMAMLTLLTA HTARCHHLSE 03500351 PPGPPGFQVT TFEGLATAGL RLRATSRAPE RSGLR

Alphafold2

.fasta

Heme Docked

PDBj

CYP2

CYP1061

>CYP1061A1 (2511976397)Streptomyces cattleya NRRL 8058 = DSM 46488 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MDNEIVLTRY ADALDAYRRK ELGQAQYDEG HVLMAGVLVN LHGTEHRDRR 00500051 RVENQLFRRE TFLHYEKEVF PDVTAAVLAP HARRGATELV ALGHELMLHL 01000101 AVLVAGVDRP EGTEAETRRL AGQLKVFIEA LTLAQSTLDK DERRAAIADA 01500151 FTDWRREFLT PSARRRRALL AGLADGTVPE RQLPRDVLTL LLRHQDRLGL 02000201 SDELIARETA FFLLVAAHTS ATAFVRAVHH LLEWTARHPE DARRAADDPR 02500251 FAQRCVHETI RLNPSSTVGM RRALAPVTLE SGITVPEGAR VVIDLRTVNR 03000301 DPAAYGPDAA EFDPHREIAP GVMPFGLSFA AGMHVCIGQD LAAGVLQSGS 03500351 GPDASLYGLV ATAVRELFAL GVRRDPAAPP VRDTTTTREY WARYPVLLG

Alphafold2

.fasta

Heme Docked

PDBj

CYP1062

>CYP1062A1 (2511978105)Streptomyces cattleya NRRL 8058 = DSM 46488---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MHDVVNCPSA PGGLPLIGHT LAVLGRPLSF FESTRTDDPL VRVVIGRLQV 00500051 YLANDPDLVH RIQVDTDTFE RGRFFEVLAG HFDNPPIASN GPAHRGQRRA 01000101 LKPVFNRPSV RQYTDAIVEE AEALAAGWRP GRLPDVRQQL SDVVACTVLR 01500151 CLFSTELSTE DVHDIQRTIY QVARRLLPGT LLPAAVTQVP TPGNRRLAEA 02000201 MGRFRVLVER LVREREEHGQ GHHDALSALL HARHGATGRP LTPREIRGEF 02500251 LVLLFAALET TSTTLAWALY EIATHPRVAA RLADEVDAVL RDGPATYDGL 03000301 QRMPYLRQVL HETLRLHPPT LFTRRTRHAV TLAGVAVPAG AEVGYSPRAM 03500351 HRHPGLHRDP ARFDPSRIGS EGALPQGAFF PFGVGAHRCI GEHLAMTTMA 04000401 AVVAAVVARW TIRLPPRVRV RETISSMPHP DSLPLQLTTR PSASRRSARY 04500451 ATARYSHPA

Alphafold2

.fasta

Heme Docked

PDBj

CYP1063

>CYP1063A1 (647545138)Streptomyces clavuligerus---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSAFPIKSIS GVEDSLADFV FDPLDAEFLE NPYPVLRALR QDHPAHWHEG 00500051 MRSWIFSRYD DCREILHDTE RFGADPRAVG QELPPARVSI QTLDGEEHAR 01000101 IQRVVVAALQ EADFTLVERR MARLLRRPPG SGADTVDFVQ DIALPVTTRA 01500151 TLSLFGLPAD AEERIADSST VIVRSMMHGL LTEGETDALA ARAAVTDILD 02000201 TWYGRTGDGL LGAIHRRPEA AALDRTALLN SLRVVLLAGI NSTQRLLSLA 02500251 VRTLLARPRG LKEFRAAPSG NRAVHELIRY EGSAQSAARF CRETTTLHGR 03000301 RVRRGEQVVA LLGSANRDER RFADPDGLDL DRHPNPHLGF GRGTHACLGI 03500351 PLTLSIARGT LETLGRDHPG AALAGPVVIE PNPALRGLTS LPVRLR

Alphafold2

.fasta

Heme Docked

PDBj

CYP1064

>CYP1064A1 (647549376)Streptomyces clavuligerus---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MDIPGPEPRA DGGVKAVADA GGLHRYQLEL HAAYGPVVRF QLPGADTAVS 00500051 IADPVLLEAT AHLDERPEGL FSFLDPLCEA GNLQVLPAAE HTPWRRLLLT 01000101 VLAGRPSHER HLPRFTALTT ALADRWAEHA EHPGHDRDDG DGGDGGGRPV 01500151 ELQKDLTALS LRMICAYALG SGVTDPEGVV TAFERVLTAH LGKLYRPPRP 02000201 GPPDEEAERT ERADAALAFL RGAVDEVIAA HRGGRAERSD LIGALVEAGE 02500251 TPARIRDTVM MTMLAAHHTT GVAVSWALYL LALHPGAAGR ATAELDRVLG 03000301 ERAAPAYTDL RRLTYLEMVL KEAMRLCPPG PYGARRTDAE LVVGGYGIPA 03500351 GTTVFYPFWA IHMNPDHWPE PERFRPERFT PRETAKRPRL AHVPFGIGPR 04000401 SCEGARLAVV EAELILAVLL KRFRFRLVPG HEVVPVERFV LWAADDIRMT 04500451 VSPRGRRQDV S

Alphafold2

.fasta

Heme Docked

PDBj

CYP1065

>CYP1065A1 (647548623)Streptomyces clavuligerus---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSPQQTARPR PDSRYGVHMS SLDALDLFDT LARPEQLSDP YPFYDWLRAN 00500051 RPVHLDPDGT VYLSCYRDSA LLKNPDIRDA AEGDGSSHTL NTYNQSLIKT 01000101 VPPQHTDLRR MGAVAFDPDL LKRAGAQVRE TAGHLADQVA EKPAHGDAAD 01500151 LHSMYSLPFT QRTAAIVFGI PDEDFDLLAA LPGRMFSALY PKADPATLAD 02000201 ADDASRALAA YVEDGLRRRR FTPDSGFDRL ARMQDTASMD DLVRLCWLLW 02500251 WASYTSSLAA IDLAVLTLLE HPHTIQALRE RPDAWVKEAL RYRSPHVINS 03000301 ANLTTSRPMT IGTVSVPAQT PVRFLISSMN RDPEAFPDAD TFDPDRPAMP 03500351 RHLTFGEGIH TCIGAKLARM ELAIALTTLV DRIPDLALAS APVWRPYTTQ 04000401 RLVSSLLVTS SPTRN

Alphafold2

.fasta

Heme Docked

PDBj

CYP1066

>CYP1066A1 (647548943)Streptomyces clavuligerus---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MASPQTPLRT LHQVPEAPGR LPLVGHVATL ARDPFRFLMG LREHGDSVLL 00500051 HLGRTPVLFV SDTELVHQAL VAQGSVFATG RIFERLGAVF GNGLPVADIP 01000101 THRKQRRIMQ PAFHRSQMGR YSTTMTANAE AMVARWSPGR RLVADTELLD 01500151 LALSNTTEIL FSSRLSDADR AEVHRSIPVI AHDVLVRAVM PAFLDPLPIP 02000201 LNRRCDTAAA RLRVIVEGIL DGHYRSPQHH DDLLTVLVQA RDPETGRPMD 02500251 GTQLRDELIT MLGAGTETTS SIAAWAVHEI ARHPVAERRL VAELDAVVGD 03000301 RPVTPADIPR LTCAEEILNE TVRLHAAPLL TRRTVKPTVL GDIRLPAGTE 03500351 VAFSPYALHR DPRHFPHPDA FWPERWQHIG SGRPRSFFLP FGGGAHKCIG 04000401 DSMAWTQLHI TLATIYRRWR LRPDRSHRVR QLPAAITRPD HLPMIAEPRE 04500451 PAPARAEGAR S

Alphafold2

.fasta

Heme Docked

PDBj

CYP1067

>CYP1066A1 (OCU_13460)Mycobacterium intracellulare ATCC 13950 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MLEFDPFKPG PADELPAVYA ALRERFPVYR TGTNIWVISR FDDVKAVQSN 00500051 PAVFSSRPNP YEGDSAPADA EMKPEVIERL MALTAGIPVD MNEMASAKTI 01000101 AAADPPQHTR IRRIVSRGFT PPRIKEMADA IAKIVDRCLS GIDELPSFDL 01500151 VERLAIPLPV EMICHILGID RSEYGRAKCW SDAFAAAAGG NFSSAAERNE 02000201 LMLTTIKEFS TYFVPLIEAR RVEPRNDLVS AMVAAIDNES LSNVETLMVA 02500251 ITIMVAGNET TTNLIGNAVV ELLANPDQLK LLLDDPSLLP NAVDEANRLT 03000301 TPIQFAFREA TEDTVVAGTT IPKGAIIALH MAAANRDPRR FDEPDRFLIT 03500351 RPPGKSLAFG HGIHFCLGAH LAGQEVRAAI GGLLPYLDRL KLTDAPLERN 04000401 PTALLNGWQR VELAWVS

Alphafold2

.fasta

Heme Docked

PDBj

CYP1067

Alphafold2

.fasta

Heme Docked

PDBj

CYP1094

>CYP1094A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----
>CYP1094E1 (COO91_10679)Nostoc flagelliforme---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MKHLSDYNFF DPEVLVCPYE FYKLAQEEAP IMELPSPKTG AKLFLVTHYD 00500051 LVIEILKDTR VFSSNFSTLL AGKEEHDPEL QKISDQGWPQ MNTLLTADPP 01000101 EHERFRSLVN KAFTSSRINK MRDLIEQIVD ELIDSFIDRG KCEFVSEFAV 01500151 PLPLKVIAQQ LGVPQADLPN FKQWSDAFIA RLGQILSREQ EIECAKDVVA 02000201 FQHYFHDVME SRQKQPQDDL ITDLIQAKVD GERSLDTAEL LSIIQQILVA 02500251 GNETLTSALA AGMLLLTNNK EQIPLVQTDI SLLENFVEEV LRMESPTAGM 03000301 WRVVTEDTKL RDVDLKAGSL VMLRFDAANR DSIKFIQGER FDVRRHNASN 03500351 HLSFGHGIHF CLGAMLARKE MQIAYGRLLI RLKDIRLAQE GYQYLPNVLM 04000401 RTLKHLYIEF DKAT

Alphafold2

.fasta

Heme Docked

PDBj

CYP1119

>CYP1119A1 (MycrhN_5325)Mycobacterium rhodesiae NBB3---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSANDPVPAP PLAVGTGLPW DVCVDDAVAA IASARARHGD TFAVASGNDN 00500051 YLFTFSPAGV EAFYRLPEDK ASKGVADYLM LRRKLPDEIF DGRRLLPTSL 01000101 FRRDDVASYL KNLDCALTET VAELGPDGTV DLFGLTRRLG HRMGLASWAG 01500151 PGSAQGTPFD RLVAAFETLD GSDAFVHPDS MAAVAAGGKQ AERAALDEIV 02000201 AVIETAVHAT ASDQVDESDL FGRIVRAWSQ EPDDVRMRGI ALDVALIHIA 02500251 SMSNLMAALG WALVDLLEHP DEQKRVASGD SEFAQRCALE STRLAQRSIM 03000301 SRAVLAPVDL DTGDVIYRVP AGWTIATLLP LLNTSAAPGL RTWDPDRWQR 03500351 HRLADTAALP SPMLVTAFGH GKHSCPAQPF SLAAMSVAMT RLLNIYEMTP 04000401 GWTSYPKPVP AQIGGVARSV DPCPVSYVRR

Alphafold2

.fasta

Heme Docked

PDBj

CYP1120

>CYP1120A1 (JDM601_3734)Nontuberculous mycobacteria (NTM)---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSDQNIDATT PFDPFTPVLD PYTPLGEAAA HCPVVAAPGG AVVITGAQNV 00500051 SAVFKDAQTF RNELRPAHPG TQPSLVHLDG DEHTRMRKLV VKAFTPRAVK 01000101 NVEAPTYAIA HELIDAFIKR GSADLCTQFA FLLPAMVIAE LVGIPAGDRS 01500151 TFVKWADDAI TAAGPNSSGY AESDPDLRAY VLGIIDQRRA TPGGDLLSEL 02000201 IQVHDGDDHL TTDELVALVR MLILAGTDTT ANLIGSMLHQ LLSEPSRWQR 02500251 LLADRSLIPN VVEETLRFDP PLYWVPRKAA VDTELAGATI PAGTLVCNAV 03000301 GHANRDIEGL ERPYEWDMDR PAARNRTHQT FGFGEHFCIG SSLARLEATI 03500351 ALEVLLERLP DLAVADSYSY QPHGPLMMRG VKSMPVVFTA GSPR

Alphafold2

.fasta

Heme Docked

PDBj

CYP1121

>CYP1121A1 (MycrhN_0267)Mycobacterium rhodesiae NBB3---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MTLHSDTPSA GQLRTATGCP FGASPAVAAP QRDATDRGQL LLRLARSGRD 00500051 AVSYRIGAER NVLLNHPDHA QHVLGSNRDN YSKDTGANRY FRTEVADGIL 01000101 TADGARWRWH RTLLTPAFRD RQRLAATARE AIAALIARFD SAADTGSEVN 01500151 LSAAIAEVTL SITTRALFGM NHQPFIEHCA ALGSVLDDAG SLLPGAAAGV 02000201 GPRDALYRQI RDAVSASATE DHGPALSALT GDPTHAGEAL HQQMVTLLLA 02500251 GYETTANSLT WAWILLMQHP DIYGEWQHLL DTDHDRAADL TKALFDETLR 03000301 LYPSAWLLGR RALADDHVGG IDIPAGAAVT ISPFLLHRHP QFWDDAESFR 03500351 PQRFLTGGTR PTHRYAYIPF GAGHRYCIGS SYAHDEAAMI LTALGARYTF 04000401 QSAHAADARP DHKFVLRAPD PFGVIVRRRS

Alphafold2

.fasta

Heme Docked

PDBj

CYP1122

>CYP1122A1 (MycrhN_3635)(MycrhN_0267)Mycobacterium rhodesiae NBB3---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MRATTLPVVS STLRDFSMMV GQGAIRDLRR ARVGSAPTRV PRTRFDPTAP 00500051 EVIRDPFPAM ERLREDPVHV NENLNVWMVA RHEDVTAAAR AHDVLSSGSG 01000101 ILLRSTVLPS VATTDDPDHA RLRRVTAPYF TPSAMRRLQG SLAQFVDPSV 01500151 DALARGDVVD LVPTLTVPLP VSAIALLLGI DRSRWRDFRV WSNGVTALFG 02000201 ARSLGGITYT IGHALPGILS LRNLILDELR LRRRDDRGDV LSGLSKALTT 02500251 GEMTSVEALS AALLVLVAGN ETTTNLLGIL LIQLAEDPEL YARLRDNRDL 03000301 IPAAVEETLR WGSPVQWVTR TALVPYEIAG TVIPARSRVV LFYAGANRDP 03500351 QRFDDPDRFD VERKPIGHTG FGHGAHFCMG AHLARLEVAV ALNGLFDRVS 04000401 GLELAGPVAW TTTPSLSGPT SVPVRAVAR

Alphafold2

.fasta

Heme Docked

PDBj

CYP1123

>CYP1123A1 (JDM601_3734)Nontuberculous mycobacteria (NTM)---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MDQRELTRRL RFRASLLRIG IDGLVGVARD RATAYRYALT GRETAPLTDF 00500051 DPFAPATMRD PYPGYRTLLS GPEVWYSRKR GIWIIPGYDA VRQALRDDEA 01000101 LSSAQSQARF RVRLQTMNAQ DPPVHTRLRR SVSRAFTPRA MKAWEININR 01500151 VADELVAAMI ERGRVEIVDD LAKPLPNRLI TMMLAIPQED RHQFLEWADT 02000201 INEAAFAPLT ARGMALNMRS SQAVIAMHRS LDPMIKARRA APGDDLISML 02500251 AAPSGEDTLS DDEVFWSASM LVGAGSETTT NLISGLFLTL AQRPDVYTRL 03000301 REHPELIPAA IEEQLRLVSP VQGFYRTATR DYRVGDHTIP AGARVLVLYA 03500351 AGNRDPRHYP HPDTFDLDRN PTDHLAFGGG AHYCLGTHLT RIEVSRVLTQ 04000401 LIPHVKEIRL AGEYRYLVNA TMRGLEHLPV ELVPAEAGAA GTATDLRSTG 04500451 SR

Alphafold2

.fasta

Heme Docked

PDBj

CYP1124

>CYP1124A1 (MAP2344)Mycobacterium avium subsp. paratuberculosis K10---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MNVNAATAAC GDDPAERGSA MTTAAVDLSD FSLWCNGFPD ELFAELRRTR 00500051 PLFHHDLTPG VAATVHRDFW VATKHRHAVR LHRDTESFTA ADGPLIQPVA 01000101 MFSSSPTIIT MDPPELNKRR KLISNAFNPR AIAKLEDGIR ARAARMIDSL 01500151 LAHGGGDWIE DVADALPMTV IGDILGIPER DRPRIFDLFD RILKALAPEA 02000201 HPRGGVELEL FASVFDYAMQ LTADKRRNPT GDIWSTLATA VITGEDGEEF 02500251 RLPANELEFF FFVLAFAGSD TTKNALAIGL QAFLANPEQV ERYCADEALR 03000301 PTAVEEVLRW ASPVAYWTRT AKVDVEMDGQ RIAKGERVVS MLRSANRDEE 03500351 VFDAPFTFDI GRQPNPHVAF GGGGPHHCLG AMLARAELRA VFDELLLRCD 04000401 DIEIGPAKAA YPNLITNMSI YDEMPISLRR R

Alphafold2

.fasta

Heme Docked

PDBj

CYP1125

>CYP1125A1 (Mycsm_03081)Mycobacterium smegmatis JS623---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MTSSVLTPID LSRSFSADLH GMLREAAAQG PLATDIDTGA TIVLRQHDVE 00500051 TLAHDPRLEG IGLILFDMMG IADGPLRDWY AKVMFTTEGD YHRRIRSLVS 01000101 RAFTPRSVGA LRDTAAQMAN DAIAAAKQTG DLLTMSSLGT RMICRLLGVP 01500151 DGDDAVFTQW AEALSPVFFV MTPEQIADAT MAIVELQSYV DELTTRRAKD 02000201 PGDDLITSLL AAESDGDCLT HDETVTMIAN LLVAGHDTAG SQIPCSILTA 02500251 LQHRDKVDGT LDDAPRFTSA VNETIRLEPS IPAIPRTAVQ PVELHDTVLP 03000301 SGSMVFLCIA SACRDASAWP EPDRFDPDRF TRPDTAKLLN FGAGTHYCLG 03500351 TALAKVAVEE AVRAVFAADP PLRLTENVGE IPWRQVLGRS PARLTVSPGT 0400

Alphafold2

.fasta

Heme Docked

PDBj

CYP1126

>CYP1126A1 (Mycsm_06649)Mycobacterium smegmatis JS623---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MVSVTPTASS DILNAIIAGG VQDPFPLYEE LREFGNGVHW SDLLNGWFLT 00500051 RADDSRAMLS DAENYSNEMH EVTGAGSHNP DDPRQRRFAE IQSNFLFFVD 01000101 PPRHPVVRSV FRSAFTPRAI SSWRPTVERM TDRLLAQFEA GDEVEFMEQI 01500151 ACVVPVEAIA TVLGVPEEDH ERFRAWSEAL TRANNPAVQG AERDSAITTS 02000201 MELVDYMAAI ADERRAHPQD DLISTVVNTP TRDGSPLDAT EALAQLVVLL 02500251 AAGNETTSNL LGNGITILLD RPQVKRRLVE DPSLMSSAVE EMLRYDPPFH 03000301 LDFRKAIKDS SISGTAIKAG TPVYSLLPAA NRDPRAFDNP LEFDVERQNN 03500351 KHLAFSHGIH FCVGAPLARL EGEVFFTKLL QRFPNISRGI DEPVRRTVNI 04000401 LSRGWETRPV RL

Alphafold2

.fasta

Heme Docked

PDBj

CYP1127

>CYP1127A1 (JDM601_0082)Nontuberculous mycobacteria (NTM)---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MAALDFDFRD PDLHADPLTY QRRFADADPV HRNSQGLWVL TRHADVLAIL 00500051 RDERAGTDRR NLYRSKLDPG RPYLTHVEHN LFYRSGDDHR RLRAPLSRAF 01000101 TPRALASFES EVAARARSLA AALDPAGFDL VAEFAKPLPL GAIATLLGVP 01500151 DSELDNLQDW SMALIAALEP AAPRSVFTAA DDAAAGMKDL LADLLALRRA 02000201 DPGHDLLSVV AASGLPLSDD ELLHNAIFLL SAGHDTTTAV LTGATALLIE 02500251 NPGQRRLLAD AGAAPHAVDE LVRLISPAMM ISRVAEAPIE LGRGKGGAVI 03000301 DPGAPILLGL AAANRDPAVF PDPDRLDLAR PQTGHLGFGF GPHVCLGAPL 03500351 ARMQIRLGLL ALFDRFADLT AQAPPRREPS AVLTSYRSYP LAGAA

Alphafold2

.fasta

Heme Docked

PDBj

CYP1128

>CYP1128A1 (BN42_20317)Mycobacterium canetii CIPT 140710010---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MTIRSATGPR LPWDAADPYP FYERHRGVAD PVWDDTAQAW LVFGYHAAQQ 00500051 VLGGPGWAID PLANPNAGLA VDAASSELFK RSMLFADGTE HLRLRGAVRD 01000101 VFTPSFITGL TAGVEAIAAA VIDHPRTATV FDFMTEIALP LPLAVMGEWL 01500151 GLDVESSRLF RTLSSATIRI LVPLATAEEI QTGAAALTRL VAHILPLAAD 02000201 RRSNPSDDLL SFIAADPDLQ LDEVVMTALN TAVGGHETTA YLLGTAAIRL 02500251 FTPRADGNRM LDELDPADPS LITELLRLES PIQATARTAT QIQRIGDTEI 03000301 AQGQQVIVVI AAANRDPAVF DEPDRLRLGR RGPAPLAFGH GPHYCLGAAL 03500351 ARLQISVALR RIVARNPVVC GAASWDRSPA LRGPVSLPMR FIGP

Alphafold2

.fasta

Heme Docked

PDBj

CYP1129

>CYP1129A1 (Mjls_4131)Mycobacterium sp. JLS---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MTDIQAESRP RAEVDLDHHS PEFREDPHGT FRKMRESGCP VAYSDHYEGF 00500051 WALVDYASVF EAARDDALFN SFPSVGVPAS ELPLPILPIE SDPPETQELR 01000101 EVTLKRFSPG SAERFRDAAI AMTDEAIDAF IERGQCDLVG ELTTPLPARL 01500151 ILRLLNFDES RAMDWVHWVH TTVHDRAHDP EKAGTAGLEM FGEIVKHMEE 02000201 RRAEGLGDDL FSDILRGQLN GEPLDDGQIT MYTVLMMLGG MDTTSGFTGN 02500251 VLLRLCEDTE LRQKFIADPG LVKKSTDELL RLYTPTLGLA RTVSRDAEFH 03000301 GQQLCQGDRA ILMWAAANRD PAMFENPDTL DLDRANAKKH MAFGVGMHRC 03500351 LGSHYAKMMF DVMVTRILTR LPDFELAGEP KMFEDAGEVF AVRELPVKFA 04000401 PGPRTS

Alphafold2

.fasta

Heme Docked

PDBj

CYP1130

>CYP1130A1 (MAB_3275)Mycobacterium abscessus VO6705---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MIASLSDDPF WPTRKPLRAS FSLLTGWGRD RPIPPGPIGL PFIGSAIPMA 00500051 RNPYKFLQDC HRRYGDIYRV PLPIHPLVLA NHPDLVSEFM ENTELKYSMS 01000101 APIQGKRLQK AVASVGCPVQ VLEGQALRDR RKRLMPMFGK RHLSVVSDKF 01500151 VEVFTDRIDR WLLVADTGKE VNLQAELPKV VLPAFMYAMF STRLSDDEVL 02000201 HADTATRSVM RAIASGLFLA SPPNIFPLRG RENLPVSGLR LMRTIRQMIR 02500251 DRRANPTDDA DLLNILLAAR GDSSRPLTEI DVYSEIMSAI GGGYETIVAS 03000301 MSWTLALLLQ HPEHLDRLYD EISILHGNAP TPDDLPRLPW ARACFDEGQR 03500351 LQGAPINPRY AMEDTELGGY PIPKYTLVAS SLYVVHRDPR WWGENAETYD 04000401 PMQFFDQDRV NARPRLAFQA FGAGPHHCMG TGMAYMMAQY LLAIIFQRYR 04500451 LHLRPGWQPR QFFSLSTLVK GGVPATITKA

Alphafold2

.fasta

Heme Docked

PDBj

CYP1131

>CYP1131A1 (G6X451_MYCAB)Mycobacterium abscessus 47J26---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSSVTFSPAD IAGLPTAPGP SGIAGAGALV RLIRDPWLYP LTLTEKYGDV 00500051 VSIPTPFVKT VYIGHPDWVD HVLVKHPDRY RRSDMVAKQM VPPKVGHNFF 01000101 AFADDQEWQR GRSLYRPSFT QKNLAELGDL FTESVTGQVD SWAQMPCSAD 01500151 GYLDIEEMTR KLALIVLFNA MFDEYLSPRM LEASVTKNAI SFGMLATTVR 02000201 VAMYSLPAWV PRPLQRRMDG LLEIIMGGAD QLIEMRRRHP TERTDILNLL 02500251 IGATYDDGRP LENDKIAVEI AGMIIGGHET TAAALAWTFA LVSGHSDIER 03000301 RLIDEVDALG GKPVTVADMA RLPLARACFD EAQRLQGGLV INPKTALVDD 03500351 EMGGYRIAAG TTILYSSLAM QRDPRFWPEP DRYNPDRFLN NEADLRAFVP 04000401 FGRGQRLCLG MRMAYIEAVL TIATAYQRYR FELPKGYEPR HQYRMSMGLK 04500451 GGLPARIVRR

Alphafold2

.fasta

Heme Docked

PDBj

CYP1132

>CYP1132A1 (X8CX78_MYCAB)Mycobacterium abscessus subsp. bolletii MA1948---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MRSIDTDSVA PAVPKPPVPR LPPRLPIHKA ALLGLSCLGD PTRLPYLLLP 00500051 KIANRYGDIV RLFTGPTPAL TLTLINHPDY VDHVFTRHHD RYVKHEATIE 01000101 LVSGEPVALP LLEGREWKRV RSAFNPYFGE RALAQATPLM MEGITERVDA 01500151 WSRHVHSGEL VDLEHELGAV VMDGLMRSMF KVRLRPAEID HAVDGARRYG 02000201 VYVISRVAMH FLPRWLPNPL RRSGEEAKAE LFGILDRFVQ ERAGCPSTGT 02500251 PDLVDTLLAL EFDGCPQIRE RRRRSEAAGL VFAGFETTAA ALAWTIALLC 03000301 RNPIALGKAY AEVDALGGKT LAYDDLENLK YLRACFDEAQ RFQAAPANVR 03500351 TAIEDDEVGG YFIPRGSQVI ITQYALQRDP RFWNEPERFN PDRFLTDKIN 04000401 RNTFLPFSIG PRKCMGTRMA YIEGTLVLGA ILQRYAFQIR DGWTPMHRVR 04500451 VSTGLAGGLP ARLFAR

Alphafold2

.fasta

Heme Docked

PDBj

CYP1133

>CYP1133A1 (MKAN_03590)Mycobacterium kansassii ATCC 12478---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MKPTIVSGPS GAAALRWWAR MARDPLATYA SLQRTYGDAV RLPFRRHRPI 00500051 LLLSRPEHAE HVLVTQQRNY VKAVTYLPLR ALLGSGLLTS EGNVWERHRR 01000101 IIQPVFARRH LNAFAPEIVA AAQRRVATWR DGDVVDAAEQ MRALTLEIVG 01500151 RVLFGASLAG SAQRIGDALG AIQHAAIISV LLSAAVPEWA GSAWLRRVPG 02000201 VAAPVSTLDA VVAEIVTRRR AETGSGDGAD LLDLLLTARD EDGSTFDDVE 02500251 IRDEVLTLML AGHETTSTAL TWTLALLSRC PAARRRLEAE VDDVLAGRPA 03000301 CADDVDRLVF TEAVINEAMR LYPPAWSIER DAVEADDIAG IPVAAGTTVV 03500351 VPPYLLHRHP QFWPNPEGFD PDRFLTETDR PRYSFVPFGG GRRICVGAGF 04000401 AMFEAKLVLA TIAQAHPLDL LSGGMPAVRT EITLRPRGPV PMRITQRLAQ 04500451 AVDRRAQPTA RDAIETIEGV PASAP

Alphafold2

.fasta

Heme Docked

PDBj

CYP1134

>CYP1134A1 (MAB_1426)Mycobacterium abscessus 103---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSASALQPEP LSAPVEVAAG ECPVNHDLYP GGPTFLRWHH TRVGYLKSWR 00500051 LALGAVWSTY RHTISEYLAD LPGQDDVIVA RAPMRKAVIV RNPELARHVL 01000101 VANQDNYIKS AEYDLLAVGF GRGLVTDLNE GLWNRNRRLV QPIFAKRQVD 01500151 LFAPQMAEAA ARTISRWDEL YAEGKPVDIT AEMNYLTMDI VAQTMFGIDL 02000201 SGDMAERMRI YFARLLKLFG VGFIVGAAPP LRWVVDKLAA HGPDELSSHT 02500251 PRLAIRALRI GASVAAPRTM KGLRWVERTI DQLIADHRSG RIARQDNLLA 03000301 LLMAAEDPET GAKYTDLEIR DELMTFLGAG FETTAAALAW TWYLLSRNPD 03500351 ARAKLGQEVD RVLGGRQPTA ADVDNLPWTA AVLNEAMRVY PPILGLARTA 04000401 KADDVLGDYP ISAGTTVMVL IDSIHHNERV WDDAKTFDPA RFLKENLQPE 04500451 QRKAHMPFGA GKRMCVASGF ANLEAIIGIA ALAQNYELDL LPGQQPRREV 05000501 TFTGGPEGEI LMRLRKRHP

Alphafold2

.fasta

Heme Docked

PDBj

CYP1136

>CYP1136A1 (Cyan7822_0990) Gloeothece verrucosa---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MTNQLLNNFL LLEEGQTPPS ETTLPPRQPQ WFDTFSYIAD PDQFCRQNLA 00500051 KYGPIFKTGV FGETTVFVGS AKVNQMAFNG DQHYTEIALP PTTMDMFGQY 01000101 SLFQRTDLHR SRKSALSPAF TGKMLEGYLP LINQVVLEGI QSWKTTDLLS 01500151 VFPAVEKICF DVLVPLLLGV DLNQKDSLKG LPISSKTELK ALYKTFFDGF 02000201 YGLVKWKSPL TVYGRGYQAR EKLLDFMGSV IQQRRAQGEV INSQADFLSM 02500251 MLAGQEENPT GVFQDIFIKN QCLLQLWASH YEICGLVSSL IYQIGRHPEV 03000301 KKRLVQEQIE VMGEQTSDKM ITSQQLKAMV FLEATIKETL RTLSPSSTVN 03500351 RRLTKSVVLD GVLYQKGWVL IAEQRIAHIL PEHFKQPDVF DPERFLSPRN 04000401 EGKMYEFIAF GGGVHACLGA QLAMLITKVF ACYLLQLLNW EVTQAASFVQ 04500451 FPLKRLKSNY QIPIHSRATA

Alphafold2

.fasta

Heme Docked

PDBj

CYP1146

>CYP1146A1 (ACK67088.1) Rippkaea orientalis PCC 8801---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSNDLNRIPG PSPQFLLGNA LDFANTPSHI RLYEYSLAYG DIMLFWLFTQ 00500051 PSILINDPAL IEQVLVIDRD RYYKNAPRKA AEPVMGDSLF LSNGQDWEFK 01000101 RRNHPFSAPQ IDTYFEQILP TIQTTTNRYL QALQPSSTPK SVELFGELVK 01500151 LSFEIFCLTV LGAEMDSSYF DAFSLLMEEM NNRGGQAFLP YPLSLNPQFW 02000201 VARQRWNSFI EEQIKERQQR SPQQGIDLLS FVIQDTKLST KQLREELSTA 02500251 YTAGTRNVAE AVAAVLFLCA KNPQVMQTLL SEITLFLRES GSDFSLAQIN 03000301 QFNYLDLVVK EALRLYPAVP FFIREVLPKQ SPMLGGYTLP EKTQIFVSSW 03500351 SFHRNPKYWQ NPHEFMPERF INPPPAFHYF PFGAGPRQCI GMAFTLTCTK 04000401 VMVVNILSQY SVELEPNTTF ETQYFSGTIM PRDGLKIKLS RQLL

Alphafold2

.fasta

Heme Docked

PDBj

CYP1156

>CYP1156A1 (Cal7507_3320)Calothrix sp. PCC 7507---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MHTPITPLIP PEHLGLNGED NQSGLAKRHQ SLTYDLFAPE VIANPYPLYK 00500051 RIREEDPVHY EASLGYWILT RYQDVEAALR DERLSANRRT LFIQQLGNLD 01000101 VSLIQNFLQL TGNSMIEKDP PDHSRMRKLA NQGFTTRALE SWRSIIQKTT 01500151 DTLLDQVQHQ GYMDIVSDLS VPLPSLIIAK IFGVPESDRA NLIQWATDTS 02000201 SFWGAPSGKN IEELAQKADT SAAQFTAFIN QLVAERRQNP GTDMISLLTM 02500251 AYTEQNLDFA ELPSLCILIL NAGRSTTTDL IPNGVSALLN HPQQLQKLKD 03000301 NPALISSAIE EIIRYDSSVS FVFRIAKEDI EIGGQKIPAG SVIALGLAAA 03500351 NHDPAKFPLP DNFDIERSPN EHLGFGPGIH FCLGAVLARM ELNICFSTLL 04000401 KRFPNLQFDS TRPPLPRRST LVFKGFDALP VRF

Alphafold2

.fasta

Heme Docked

PDBj

CYP1158

>CYP1158A1 (Cyan7822_5890) Gloeothece verrucosa---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 FKLHGHLFEC HQFNVSYAPL MGKNALFLQD GEAHKRLRRI MMPPFHRERV 00500051 QKYADYIQEI AQESVKDWTR GKVLKIRSLM HRLALEVTLR IFFSERTLPI 01000101 EKIRYWFETK VFTETKSWKP WFNYSRLQPQ IRQLIREEIE FRKEAKFESV 01500151 DLLNWLQLAQ DEEGNFLSEE ELQDQLLTLM ITAVDPIAMS LTWALYWIHK 02000201 LPKVKATLSE ELKTLEGKLD PLAINQLPYL TAVCQETLRL HPILPTVSGR 02500251 RLTTPIEVMG YHFPEGTTVA PCAYLVHRRE ELYPEPRSFK PERFLQNQYS 03000301 AYEYFPFGGG NRLCLGAALA PLEIKIVLAT ILSSHDLSLM DQEPLSMVRY 03500351 GTLVAPSETF QMIVIK

Alphafold2

.fasta

Heme Docked

PDBj

CYP1159

>CYP1159A1 (ACK66447.1) Rippkaea orientalis PCC 8801---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MFKGLKIALQ ADTGRWFTRC NNCQQTIGNN PDTVTVHVEG SVSEHPYAQF 00500051 EVVDVGNGKI ALKADTGKYV GRCNGCIVGG AYPDFLTIHV DDPSMPWAQF 01000101 TPERLANGKY AFKADTGKYF GRCNGCSPTS AYPDTVAVHV DNPHNSPWAQ 01500151 WTVSYVPFSY LERYDAIPAD NVAEKAKLVG RAMATDSRNF FKELRANRPI 02000201 FITPKFVLVT LFPDVQEVFS RPEVFSVRLY APKMDPNHGP AMLSRDNTVY 02500251 NWREKSIMKT MLDWEDLPRI KQAAGEVAKA ALDKFAPTKK IETVNELAKW 03000301 VLVRMSGDYY GFPGPDRETM YRWSSATQSG MLRNLANDPQ IHEASVQAGK 03500351 EMRDYLTQLL QQKKANNTPS TAPKDIFTRL VQANLTSDIP FDESRILTNM 04000401 ALLLISTLDT TAQAIVQSLE QLLRRPDILP KAVAAAKAND DVTFAKYVWE 04500451 ALRFNPVSPA LPRFCESDYT VAAGTSRATR IPANSLVLVS LGSAMMDGAI 05000501 VQNPEQFSIE RPKHNYMHYG YGDHTCLGEH IGNVVVSEVI KQVLLRPGVR 05500551 LIPGDEGKLQ AQPNAILKSF VIAYDG

Alphafold2

.fasta

Heme Docked

PDBj

CYP1177

>CYP1177A1 (AFY47549.1)Nostoc sp. PCC 7524---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MFIFLEINLI QPDKLAESLG LVAVLSIVAL LMRSHYFPKG SNPNLPPGSY 00500051 GLPLIGETIP LALDIHSFYR ERVQKYGPIF KTHLFGKPVI IFNGPEAFTF 01000101 FLNQEYFTRA NASPKPIQEL LAWDALPLLD GDEHRRRKRI ILQAFTPQAF 01500151 DQYIPLIEQT ANYYLPRWEK LGSFVWLTEY RKFSASLTNA LFIGTAPGAS 02000201 SEAVGEITDT FIKGFSAIPI NLGFNAYGKA LKNRDWLLNY IDQAIEQHRQ 02500251 QPRKDLLGLV LTSRGEDGST LTDDQLRREV MHLFFAAYSG FYVALTLLSL 03000301 TLAKYPEMTA RARKEVNQYV PDGALDMAKL QKLVYLEQIT KEIRRFYPIN 03500351 AATFFGQVKQ DCEFHNFRIP KGWGAVAGIH TTMQMPQVFA EPQTFKPCRF 04000401 APENFATLPE NSYVPQGGGP RDGHRCAGED LVTVLLQVMG VYLLRRYTWE 04500451 LPPQNLEFNQ DLFPTPKDGL KVKFGIHQQA V

Alphafold2

.fasta

Heme Docked

PDBj

CYP1184

>CYP1184A1 (AFY56912.1)Rivularia sp. PCC 7116---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MIQQNNTQST KTCPFHAGKE YQPFVEPQLE NPYSFFQIAR NQEPVFYSSV 00500051 VNAYVITKYE DVLNILKNPT IYSSAKSLQT AGDMTPEAGK VLQQGFPFVS 01000101 LINSDGEKHR RLRSPFLKVF AADKLAKVEG SIYAIANRLV DNFINDGSVE 01500151 IVSKFGHPLP LEVILTMYGV PLEKMEQVKK SGSDISMFFS SKLTPERQIE 02000201 CAQSYVSLQH YIASLIEQKR SAPGNDLISQ LLTSDLTTPE IVLMLCEMII 02500251 AGHKTSANLI SKALKLLLDT PGAWQALHEN LSLIPIAVEE VLRYDTPAQS 03000301 MIRVTTQEVT ISGVQIPKDS RLLVLYGSAN RDSEKYENAD KFNIERFKDA 03500351 PVDHLAFSHG THHCTGSNLA RREVRIALEV LSQRLPNLRI TSNQELHHLP 04000401 ILTNRGYESL YLEWD

Alphafold2

.fasta

Heme Docked

PDBj

CYP1185

>CYP1185A1 (AFY57880.1)Rivularia sp. PCC 7116---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSKLANNQTA PLEFNPRSPQ FRANPYPTYD YLRTHHPIYY RSERNDWVLT 00500051 RYDDIVEVFR NPSFGRSQQK PKLQTANQQP INHFLSLRQE SQQLMKLWLV 01000101 LLNPPDHTRI RHLLRNPFTP SRIQTLRSHI SANVNNFIDG VKNSGKVDII 01500151 KDLAYPLALG VNCKILGIPE QEWHPRFKQW SDNLSIIADV DVTPIANEQG 02000201 LLTIAGLAEY FRSWIAKCRS CSQPQDNLIG SLIEAEANGE ISEEELLGTC 02500251 IFMFAVGHSS TANLIGNTIL TLLNHPQQLY LLQADPSLIE TTISEVLRYE 03000301 SPVQGISRTA LSDIQLSNQT IHRGEVVNCI IAAANRDPAK FLEPNKFDIR 03500351 RKPNPYLSFG QGIHNCIGKH LGRLVAEIAV GTVVKRLPEL SIATESFEWD 04000401 DSFLGRGLKS LPVIF

Alphafold2

.fasta

Heme Docked

PDBj

CYP1200

>CYP1200A1 (651287498)Streptomyces sp. Tu6071---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 ATSAPPQPSV DGIPNLDPVP TFVPLAARSG GGLPLIELPS GHTAVHLTRY 00500051 ADVHRVLTDP SFGRTATNVE DGPSFLPTIM PKELLLNLDM PDHSRMRGFV 01000101 NADYSVAGVE RLRPLVRELV AAKAARLRGA ERPDLYATVL DTLPAEVNGR 01500151 FLGIPDADIA YYRPLGHTVQ VASHEDVPGL VADFTELYTY LTGLVTGARP 02000201 RIEGGVIDRF LAARDTVEPP LDDAELVGIL LGSVLGADQN ILSVASKIAY 02500251 VLLCRPVLWQ RLAAEPGIAP RLVDELIRLI PLGNISAFPR IAGRRIELAD 03000301 GVVEEGDVVY PDAFAANRDP EVFPEPLLID PDRTGKRHLQ FGYGMHHCMG 03500351 AALARMEIAE LLTTLAAEFP TLTLDTDPAG LTWDSGVILR RPVTLPVRW

Alphafold2

.fasta