CYPSD - CYP152_UMAP_identity

Reference

Cytochrome P450 HomepageNelson, DR (2009) The Cytochrome P450 Homepage. Human Genomics 4, 59-65.AlphafoldJohn Jumper, Richard Evans, Alexander Pritzel, et al. - Highly accurate protein structure prediction with AlphaFold. Nature, 1–11, doi: 10.1038/s41586-021-03819-2 (2021)ColabfoldMirdita M, Ovchinnikov S and Steinegger M. ColabFold - Making protein folding accessible to all. bioRxiv, doi: 10.1101/2021.08.15.456425 (2021)Localcolabfoldhttps://github.com/YoshitakaMo/localcolabfoldAutoDock VinaO. Trott, A. J. Olson, AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization and multithreading, Journal of Computational Chemistry 31 (2010) 455-461

D. R. Nelson's

Bacteria_1

Bacteria_2

Bacteria_3

https://twitter.com/P450nelson/status/1501396401317883904

CYP152_Conssensus sequence

>Consensus/1-484 Percentage Identity Consensus MTTDEGRREEEMGTMMMMAEIPRVDPGLDSTLALLREGYLFISRRRRRLGSDPAAGDVFETRLLGGRPAICLRGEEAARLFYDEDRFKRRAGAMPKRVQKTLFGEGAVQGLDGEAHRHRKAMFLDSLMTPKERVERLVELAEREWRAALIARWEAGGEVVLYDEAAEVLTRAVCRWAGVPLDEMSKAEVDRRARELAAMIDGFGALPGPRHKGYWRARLARRRAERWAADLIEAVRAGKLEPAPEGSALAVIAWHRDEDGELLPARVAAVELLNVLRPTVAVARFIAFAALALHEHPEWRERLRAEGDAERGSLVDDDYLEAFAQEVRRFYPFFPFLAARARRDFEWDGYRFPKGQLVLLDLYGTNHDPRLWENPDEFDPERFLGWDKDIGAESPFDFIPQGGGDHATGHRCPGEWITVELLKAALRFLAEEIDYDVPDEQDLSVDLRRMPTRPRSGFIITNVRRKADRAADHADAEQSQTVIR
>Top20_ConsensusMAEIPRDPGLDSTLALLREGYLFISRRRRRLGSDVFETRLLGRPAICLRGEEAARLFYDEDRFKRRAGAMPKRVQKTLFGEGAVQGLDGEAHRHRKAMFLSLMTPERVERLVELAEREWRAALARWEAGGEVVLYDEAAEVLTRAVCRWAGVPLDEAEVDRRARELAAMIDGFGAPGPRHWRARLARRRAERWAADLIEAVRAGKLEPPEGSALAVIAWHRDEDGELLPARVAAVELLNVLRPTVAVARFIAFAALALHEHPEWRERLRAGDDDYLEAFAQEVRRFYPFFPFLAARARRDFEWDGYRFPKGQLVLLDLYGTNHDPRLWENPDEFDPERFLGWDGSPFDFIPQGGGDHATGHRCPGEWITVELLKAALRFLAEEIDYDVPEQDLSVDLRRMPTRPRSGFIITNVRRK

CYP152 Subcluster_Conssensus sequence

>01_A_Consensus(209)_AEHKMNEQIPKDKGLDNSLALLREGYLFIKNRRDRYQSDIFETRLLGQKVICMSGEEAAKLFYDTEKFQRKGAAPKRVQKTLFGENAIQTMDGEAHKHRKLLFMSLMTPERLKRLAELTMEQWEAAIDKWEKMDEVVLFDEAKEILCRAACEWAGVPLKESEVKERAEDFGAMVDAFGAVGPRHWKGRRARNRAEKWIEGIIEDVRSGKLKAPEGTALYAMAFHRDLDGNLLDTQMAAVELINVLRPIVAISTFITFSALALHEHPEYKEKLRSGDDDYLEMFVQEVRRYYPFFPFLGARVRKDFTWNGYEFKKGTLVLLDLYGTNHDPRLWENPDEFRPERFKEWKGSPFDFIPQGGGDYYKGHRCPGEWITIEVMKVSLDFLVNKIEYEVPEQDLSYSLVRMPTLPKSGFIMSNVKRKF
>02_D_Consensus(179)_DMLDSTLPLLAEGYAWLPDRRRRSGGGVVRTRLLGRPAVALRGPDAVRFFYDERHVRRHGALPEPVLDTLFGHGAVHTLDGEAHRVRKALFLSLLKDPDGVAGLVEHVTAAWDEAVAEWAGRPRVVLFDEAARVLTRAVCRWAGVPLDDDEAEALARDLVAMVDGFATAGPRHWRARRARARQEARLARLVEDVRSGAVPTAPAGSALEAVARHRDADGELLDPRTAAVELLNVIRPTVAVAWFVAFAAHALHRWPEHRERLRAGDPAYAEAFAHEVRRFYPFAPFVGGLAARDLEWRGEPIPAGTLVLLDLYGQNHDPELWPDPYAFDPERFLGREPGRDELIPQGGGDPATGHRCPGEDITVALLEALAVRLARLDYTVPEQDLRIPLRRIPTRPRSGFVLTGVRAP
>03_B_Consensus(134)_BGMPEIPRDKGLDSTLALLRDPYRFISRRCRRLGSDVFETRLLLRKTICMTGAEAARLFYDPDRFVRAGAAPERIQKTLFGEGGVQGLDGEAHRHRKAMFMSLMTPERIEALAELTEREWRRRARDWARMEQVVLYDELQELLTRAVCAWAGVPLPEAEVPRRTRQLTALFDAAGAVGPRHWRARLARRRAEAWLAGIIEQIRAGRLQPAPEESAAHVIAWHRDLDGALLPPRVAAVELLNVLRPTVAVSVYITFAAHALHRHPEWRERLASGDPGYLEAFVQEVRRFYPFFPAVAARVREDFEWRGYRFPKGRRVLLDLYGTNHDPRLWDEPEEFRPERFRDRDPSPFDFIPQGGGDHHTNHRCPGEWIAIELMKVALRFLTREMRYEVPEQDLRIDFSRLPALPRS
>04_P_Consensus(128)_PQMATIPRDRSPDSTLAFLREGYRFIGRRCDRLGSDIFQTRLLLRPVICLRGREAARLFYDPDRFTRRRGAMPPRVQRLLQDRGSVQGLDGAAHRDRKAMFMSLMTPAAIRRLGQLFDDEWRARIPRWEGAGPVVLYDEVGRVLTRAVCAWAGVPLAEAEVARRTAELHAMIEGAGAVGPRHWRGLLLRRRTERWARDLVERVRAGALPAPEGSALAVIAEHRDADGRLLPRRIAAVELLNVLRPTVAVARFIVFAALALHDHPAWRDRLRAGDDAALEAFVQEVRRYYPFFPVAAGRVRRPFDWRGHHFPRGDWVLLDLYGTNHDPRLWPEPERFRPERFAGWRGDPFGLVPQGGGDHATGHRCPGEWITIELMKRAVRLLTGAMRYDVPPQDLAVDLRRMPALPPSGFVITNVRRTA
>05_M_Consensus(85)_MMKEVPEVKIKLTDVKELYNKGYNLLGELREEADAPVVKAKFLNKEAIAIYGEEAAKKFYDPRNFKREGAMPKLVLKTLFGEDGVQTLDGAAHHHRKNIFMDLMTPERMEDYHRILDKNLTQELDQQHGQFELFDLSKDVLFTSICEWAGINLAQYSKEEIDKLADYQISMISGAVTSPIDHIKGVENRKKSEKWAQSLIEEARKNPVAGKENVALYAFANATDLDGELLPIEVAAVELLNIIRPTVALTVWAALMGHALFSRPDLYQQLKNDFDTLQDSFIQEMRRYYPFFPMLPAIALQDVEVDGYLIPKDSWVVLDLYGTNHDERTIEAPESFMIKRYVGKAKDISYEEEYEMIAQGGGDFRQMHRCAGEWITLHSLRVFSDQLVNKYEFSVPEQDWTIPMNQFPTYPNSKALLYKE
>06_N_Consensus(76)_NMHKSMPKEEGLDHTLSLLKEGYLFIMNRRKSFQSNVFETRLLGEKAICLTGKEAAELFYDNDKFKRKGAAPKRLQKTLFGEGGVQGLDGEAHRHRKAMFMSLMTKDSLEEITKLTREEWERALEKWESEDEIVLYEEAKKVLTRVACEWTGVPLQEEEVEKRTDQLSDLFESAAALGPKHWKGRRSRSKAEEWIEDLVEEVRNGKLEVDEDRALYQFSWHRDENGELLDKEVVAVELLNLLRPIVAISVYIAFTALALHQFPEEAEKLKGGDEDELQWFIQEVRRFYPFFPFTAARVKQDFEWNGYEFEEGTLTLLDLYGTNHHPDLWENPDTFNPERFKDWQGSPFDFIPQGGGEFDIGHRCAGEWVTIDIMKETLDFLVNHLEYDVPEQDLSYSMNDIPSLPKSKVKLTNIRRK
>07_O1_Consensus(64)MAAMLIDDSLSLLTRGYGFGAHIWRRARPGARAVPMRLLGRPALLVRGAEGVELFYDESRIARHGAMPAIVQETLFGHGSVHSLDGAEHRHRKATFVDVAYEDEQVERLTPLLEREWRRELDAWLAGGTRSAYDAAVGAFGRAIMRWAGLPGTPAAKTRWAARLAQIVDGFGVPYSPEYLLAVLNRRWSDRHAARLIEAVRAGRLDPAEGTALHEWAWHRDRSGALLPARLAGIELQNSIRPMIAVARFVAFAAKELHDRPEWRERIAAETAERGSLVGGPLATAFAQEIRRTAPFVPMLPGWATTDVELDGERVPAGGRVVLDILGTDTDERSWERADRFDPERFLGVDDYEAITTFVPHGGADVATGHRCPGEKLAIAGLAAAVAVLSDPRLTILDEGLDVNRRRLPTKPASGGRVRAAGAAGGRCPFH
>08_L_Consensus(38)_LMAKRIPKDKGLDNTLKVMKEGYEYVPNRLEKFNTNIFETRVLGGKRAVVISGKEAAELFYDNDKIERKGTLPKRVVNTLFGKGAIHTTTGKKHIDRKALFMSLMTEENLKYLRELTRNYWFMNTERMQQMDEVNVYKESIILLTKVGFRWAGIIATPEEIEQIAKDMDIMIDSFKGLGTAYKGYREAKKARARVEDFLEDQIIAVRKGKIHPEEGTALYEFAHWEDMNGNPMDSRLCAVDLMNVIRPLVAINRFVSFGVLAMHEFPGEREKVAVNDPDYAYKFAQEVRRYYPFVPFLPGKAKKDIEFDGYKIKKDTMLILDIYGTLHREDLFENPERFNPERFENWDGSPFDLIPQGGGDYYTNHRCAGEWMTIIIMEETMKYFANEIDYDVPPQDLTVDLTKLPGKVKSGMIIENVRPNVDRT
>09_O2_Consensus(30)MTSPFGRTRSEQGLSFLRSGYLFASRVRRRAGLSPDSGCPVRMPLLGKKAVLVRGEEGVRLFYDTSRVKRDGAMPGFIQGPLFGAGAVHGLDGEAHRVRKNQMADMAYEDERVAAFKPLVAEELEALLARWKDGGGNVYDDTALAFGRAAFRWAGIPLSDEEMDRRARRMSRLLDTFGRPATNPVAWLERIRLDRWATALIEDVRSGRVTADPDSVLAHMADLRDENGELVDAKTAGIELQNLTRPTVAVARFAAFAAVALVEHPEWAERIRAASEARGGRLLDVPEAVAFAQEVRRVYPFVPMLPAEATEDTEISGCPVHKGQRVLLDILGTNTDPASWDRAATFDPERFLGVEDAEAIETFIPQGGADVRTGHRCPGEKIAVTALSAAVVALCRPEVQISSDQDDLTFSWTHMLTRPATGVRVRVAR
>10_R_Consensus(25)_RMSDIPRDPHLESSLALLGEGYPFIRDRCQRLGSDVFQTRLLMQNTICLSGEEAARLFYDERLFQRAHAAPRMLQKTLFGQGGVQGLDGEAHRHRKRMFMSLLDPAAVAELVRLSEQEWRAAIETWQARDRVVLLPEVQAILTRAVCRWAGVPLAEAEVAQRRDQLAAMIDGAGGIGARHWRARKARKEAEAWLADLIEQVRAGELPADPTSALAVVAHHRDLDGALLDERVAAVELLNLLRPTVAVARFIIYAALELLAHPQWRERLRQDDAALEPFAQEVRRLHAFFPFTAARVREDFEWQGYHFPKGTRVLLDLYGTNRDARLWEDPEAFDPERFLTWDGNAFNFITQGGGDAAEGHRCPGERLAIELLKSALRMLTREMTYAVPAQDLRIDLSRMPAQPESGLVISDVRPVAR

>11_New_Consensus(22)MKVKTPIPKAKGLDNTLSLIKEGFHFLPNRRKELGSDIFETRLLGKKAICIAGEEAAELFYDNDYFKRKGAAPKPLKKSLLGEGGLHGMDGEDHHHRKRMFLSMMTPERLEDLKRMAIEELDAKADEWEKMDEVVLFDEIEEILTRAGCHWAGLPLKESEVKQRTQELVAMVDSFGGSLSRFKEGKKARESHEKWLKGIIKDIRKGKYNPPPYTAAYIVAHHREPNGKLLDLHTAAVELNNAYRPLLATAYFIVFGALAMHEHPETREKLQADENNYSHMFAQEVRRYYPFAPAMAAKVKKDFTWHGYHFKKNMLVVLDLFGTNRHPDSWENPDEFIPERFKNWKGSPFSFVPQGGGDHHTGHRCAGEWLTVMVMRSFFKYFAENITYDVPEQDLSYDMERMPTMPKSRFIITNVKKLKDSPENLIEHEQSQTVIR
>12_O4_Consensus(19)MLKDRTVDLLRRGYTFTDWARARAGDPAAPRAVPVRLLGRPALLVRGPEGVRLFYDTTLMRRRGAMPAAVAAPLFGRGAVHGLDGDEHRHRKAMFLDALMDPARVADLVDLADREWARALIRVWRGGGTGVVYDAAVEVYGRAVLRWAGVDVPDMAQADRRARRLAAIVDGFGVPGPPYLRAWAARRWCDRWAAELVRRAREGERTPPASSVLELVAAHRDTDGQLLPAHTAAVELQNVLRPTVAVARFAAFAALALHEHPEWRARLRAEVAERGSAVGGPLATAFAHEVRRLYPFVPLLAARARQPLEWGGHPVRAGQRVLLDVLGTNHDPGEWERPDAFDPERFLGTDAEWAENFVPQGGGRPETGHRCPGEPVTVGLLALTAAHLAGLDWRLDSQGLGFDLGRMPTRPAGGVVLTLVD
>13_C_Consensus(16)_CMTTDEGRREEEPGTPASPREIPRDPRLDATLALLREGYRFIPNRCDRLDSDAFRTRLMLREVICLRGPAAARLLYGAEGLTRVGAMPSTVLHLLQDKGSVQQLEGPAHRHRKALFLRILMDPARVEALVAEFRAAWRERLPAWEAEGEIVLQQEAARLLTRAACRWAGLPHQIPEAARLARELFDMIDKAGSFGPRNWLALMRRRGTERRLRALVEEVRAGEVVPEAATPLHAIAFHREEDGALLDPSVAAVELLNLLRPIVAVGRYITFAALALHREPTWRELFRSGNLELAGDFAEEVRRASPFFPFTAAVTTRPVEWEGHDLPEGQWLLLDLYGTTHDPRHFPEPTAFRPERMLSWRGQDDAFVPQGAGDVARTHRCPGEMITVELMKEAIRLLCCEMDYEVPPQDLGVRLNRMPAQPRSGMILSAIRRRA
>14_New_Consensus(14) AAGIPALPGLDSTAAVLADGYLFGTRGFDDVGADAFRTRILGRPVVVARGIEAARFFYEGGRFDRAGALPGSVLHLLQDEGSVQTLEDERHRRRKRLFLDLVETAEERSRLVSAFADEWQASAARFAGEPVPLQDVAAEVLGRAVLAWAGIALDEEEALARSDELRSMIDNAGRFGPPNWAARLRRRRTERWARGLIEASRAAGDPPTILGRIAHHEEDGALLPEEVAAVELLNLLRPTVAVGRFVVFAALALHRHPEWRERLRDGEERAAFANEVRRFYPFFPMVGGRARRELEFRGETLPAGQWMLLDLYATDHSPAHWEAPDVFDPERFAAPVDRNGFIAQGGGHYGADHRCPGEPATVDLLAAALELLTAGHPYDVEPGQDLRISLRSFPAEPEDGFVVTFR
>15_New_Consensus(10) MAGGRDQSLALLRDGYRFWENLRRDADSDVVQTRLLGERATVIRGADAARFFYEEPALERSSALPPILVGPLFGHGAVHTLDGDAHAHRKALFNDLLGAAAVRDVADRAARRWDERAPRWGGEVDVFEEASAVLFEAVCDWAGLALEPEGVARRARDMLAMVDGFGSPGARQLRARRARRRTEAWVEALVEEARGSGEAETPLGVVARHRDEDGELLPAHTAAVELINLLRPLVAVSWLVAGLAEAFDEWPALREALASGSVSPKAVAQEVRRTYPFVPFLAARATRDLEWEGVTIPAGTLVVLDVWGTDHDPRIWRDPEVFDPERFADRPVTPYNLVPQGGGSAETGHRCPGEDLTLAVLATLAPRLAELDATVGGPPAGLRRMPPRPTCRVRVRAAT
>16_New_Consensus(9)MPPIPRSPAFDETLSLLREGYGFLSRRCADLDTDIFRTRLMLRDVICMRGPAAARLFYDDARLTRVGAMPQTVLRLLQDKGSVQQLDGAAHRHRKAMFVRILMEDKGGLDRLVAIFRRHFLERVPDWSRMGAVALGEEADLILFRTALAWTGAPVDADDDEDDAALLADMIENAGHFGPRTFGALFRRSRLERRLRAAFRAIRRGKLTPMPGSPLAMLAGYRDAHGELLSPEVAAVELINLLRPIVAIGRYIVFAALALERHPQWREILAEPDDEELTDFAEEVRRISPFFPFVGAVARASFDWKGHRIRRGQWLLLDLYGTCHDEAAFPAPDEFRPGRGLRWDEADYSFIPQGAGSPARGHRCPGEKATVEILKEAVRLLAGVIDYRVPEQDLSVSLSTVPAGPADGFIISGVAWREMEAA
>17_O3_Consensus(8)MTTMSTIRSTLGTKVDQAADLLADGYLFQERLRASKGRDAGDGCPLDFRLLGKPALLVRGSEGVDLFYDTKRIKREGAMPLPIRGPLFGAGAVHGLDDDAHLARKAMFVKVAYDDAQVERFKPLVEDELRKAVQRWRRRPGNVYDDAVIAYGRAALRWAGIPGDDAELDVWAERLGQIVEGFGHLPLAHALAWVNRARCDAWAADLIREQRSGEINAAEGTALCEWARHRELDGSLLDAKTAGIELQNSTRPAIAVARFAAFAARALVEHPQYRERIAAEVASRGTLVDNPHAIAFAQEVRRLSPFVPMLPAFARDDFEWDGEQIKEGQRVIIDVLGTNTDPSEWEEPDRFDPERFLGVDDAEAIEAFIPQGGGDVATGHRCPGEKIAVTELAATVSALCEPGVEIDPGDLDFDPTEMPTRPRSGGRVRAT
>18_New_Consensus(7)MRQDGALGLLRQGYGWASRLRAGRAAVPTRFLGRRAVVVGGPEGVRRFYDPRLRRAGAFPAPVKLVLFGPGSVHGLDDAEHHHRKARYLELLTPAAVDALRSRAEREWEAAARAWAPGRPFVLFDEAVRVLTATVLPWAGIPAGPDEVPRRARQLAAVLDGFARPGPPYARAAAARRRLDRWAAGLIRAARAGRLQPPPGTALDVMAQARDADGRLLPARAAAVALLNVVRPTVAVAWFVAFAGVALHHQPYWRERIAAGDDAALGAFAQEVRRRYPFVPVLAARARTDQDVLGVDVPAGGYVVLDVHGTDHDPAHWPDPDRFDPGRFLGGPVDPDTLVPQGGGALRTGHRCPGEDVTLVLLEEAVRRLALTPYELPPQDLTVDLARVPTRPRSGVLLAVAP
>19_New_Consensus(7)MGRTDIPPLASLDSTLDLLREGYPYISEQCDRLGTDVFESRILLKKTIFMRGEEAAELFYDDERFKREGAAPKRLQKTLFGEGGVQGLDGEAHRHRKAMFLSLMSEARIDELLQLVEQHWQEALNDWESQASIVLLDELHRILCRAACEWAGIPLHNVDAPEMTEKLVLMIEGAGAIGPKHWRSRRARKQAENWAIDLIKQYREGLLEPDEDSALAVIADHRDLDGKLLPLRIVAVELLNIIRPIVAVARYMVFAAHAMHEHPDCREKLRHSGDSDYRRRFIQEVRRFYPFFPFLAARVRKDFTWNGYRFKRGRQVILDLYGTNHDPKRWENPDQFYPERFEQEDGSRFNFIPQGGGDHATGHRCPGEWITLALMDLAIHKFAEQIDYDVP-EQDLTVDLNRIPARPRSGFVISNVRSIDKVQADAE
>20_S_Consensus(2)_SMALAALPQDPALDSTFSLIRKGYRFISDTCRALDTDVFRTRLLFRPVICMQGAEAARLFYDNDKFLRHGAMPARAQKTLVGVGGVQSLDGAAHRHRKHLFIRELMSPERIEALACLHRAHWHAAIAAWPIGEEMVLFDEAQKILCKSVCAWAGVPLPASELDRRAKEFGRMIDSGARLGLHHWRGRMARKSAEKWLGAEIEKIRASGEEAADSILQAFAWHRDEHGDLLPAGVAAVELINVLRPTVAIAQLAAFSALALHEYPAVRAKLENGHEDYLDWFVLEVRRFYPFFPFLAAYAREDFNWQGFEFKKGMLTLLDIYGTNHDPRCWEQPDEFIPERFKNWDQDEYGLIANGGATYEEHHRCPGEWITHRLMKVALRFLVDNLEYTVPAQDLSFSLARIPALPKSGMIIAPVAYPASLEKEHADA
>21_Out_ConsensusMAADAISAEPLRELPAKFSLPLVGDTLAFVRDPAGFLEKRAHELGPVFRIDVFGKPTACFVGPEAFAIFLDDKNVARAGANPPHVEELFNPEAVPFLDGEAHRRRKRLLMQAFTAEALDGYLPTIAQVIDRYATRWAGLGRFAWVPELNAMGFAIAAALFVGADPDEDDPRIEAAFDRFAAGLLSLPIRLPGTKFTRALQARDALLALIDRAIDEHEDSPSSDVLSRLLAARDGGDKLSRDEIRIETFHFFGAYAAVIGGLSFLAQCLGRDPEVRARAREEILRELPAGPLDLAAIRKLEYLDRVCKESRRVAPVLPITFFGKVKRECSFDGVRIPAGHKAVGCIGATLLDEAIYPDPGRFDPDRWLRATDRQDKAWIPHGGGIHAEGHRCAGEALATLMLKVFAVRMLRRFDWSVPEGQDLSPTKGKLFATPANGLQVRLTLLAS

3DUMAP_DBSCAN

>Cluster_00 (614)CYP152A1, A2, A3, A4, A6, A7CYP152B1, B2, B3, B4, B5CYP152C1, C2CYP152E1CYP152G1CYP152H1CYP152J1CYP152K1CYP152N1CYP152P1, P2CYP152Q1CYP152R1CYP152S1
>Cluster_01 (74)CYP152M1 Con-05
>Cluster_2 (83)Con-09,17
>Cluster_3 (159)CYP152D1Con-2,18
>Cluster_4 (12)
>Cluster_5 (25)CYP152A5
>Cluster_6 (42)CYP152L1, L2Con-08
>Cluster_7 (51)Con-04
>Cluster_8 (10)Not CYP152
>Cluster_9 (14)
>Cluster_10 (15)
>Cluster_11 (24)Not CYP152
>Cluster_12 (18)Con-12,15
>Cluster_13 (42)Con-07
>Cluster_14 (16)

3DUMAP_DBSCAN

>CLASS_0 (99)CYP152J1CYP152K1
>CLASS_1 (126)CYP152P1, P2CYP152Q1
>CLASS_2 (75)CYP152B1, B5
>CLASS_3 (21)CYP152R1
>CLASS_4 (9)CYP152N1
>CLASS_5 (66)CYP152A2, A6, A7
>CLASS_6 (15)
>CLASS_7 (56)CYP152H1
>CLASS_8 (24)
>CLASS_9 (54)CYP152E1CYP152S1
>CLASS_10 (12)
>CLASS_11 (16)CYP152A1
>CLASS_12 (6)
>CLASS_13 (17)CYP152B2, B3, B4
>CLASS_14 (9)CYP152G1
>CLASS_15 (7)
>CLASS_16 (10)CYP152C1, C2
>CLASS_17 (8)CYP152A4
>CLASS_-1 (1)

CYP152_01_A

>009_AMNEQIPKDKGLDNTLALLKEGYLFIPNRCRRYQSDIFETRLLGQKVICMSGEEAAKLFYDEERFQRKGAAPKRVQKTLFGENGIQTMDGEAHKHRKLLFMSLMTPERLKRLAELTKKQWEAAIKKWEKMDKVVLFDEAKEILCRAACEWAGVPLKESEVKQRADDFGAMVDAFGAVGPRHWKGRRARNRSEKWIEGIIEDVRSGKLKAPEGTALYAMAFHRDLDGKLLDTQMAAVELINILRPIVAIATYITFGALALHEHPECREKLQSGDEDYLEMFVQEVRRYYPFGPFLGARVRKDFTWNGYEFKKGTLVLLDIYGTNHDPRLWENPDEFRPERFKDWKGSPFDFIPQGGGDYYKGHRCPGEWITIEVMKASLDFLVNKIEYEVPEQDLSYSLVRMPTLPKSGFIISNVRRK
>Consensus/1-541 Percentage Identity Consensus MKKCKKKKRMAMAIEGSGFTIDFGCEEGEGEKKMMSMNEQIPKDKGLDNSLALLREGYLFIKNRRDRYQSDIFETRLLGGQKVICMSGEEAAKLFYDTEKFQRKGAAPKRVQKTLFGENAIQTMDGEAHKHRKLLFMSLMTPEKRLKRLAELTMEQWEAAIDKWEKMGDSLSETLRDEVVLFILFDEAKEILCRAACEWAGVPLKESEVKERAEDFGAMVDAFGAVGPRHWKGRRARNRAEKWIEGIIEDVRSGKLKAPEGTALYAMAFHRDLDGNGKMRLLDTQMAAVELINVLRPIVAISTFITFSALALHEHPEYKEKLRMKAYGNGKAYGNGAEAASGADCASDDDYLEMFVQEVRRYYPFFPFLGARVRKDFTWNGYEFKKGTLVLLDLYGTNHDPRLWENPDEFRPERFKEWKGLSLPFDFIPQGGGDDYYKGHRCPGEWITIEVMKVSLDFLVNKIEYEVPESEDQDLSYSLVRMPTLPKSGFIMSNVKRKFSAAPAAASAPPAAKAAATAAASGCPFHHGAAAHAAPGPLAAH
>02_A_Consensus MNEQIPKDKGLDNSLALLREGYLFIKNRRDRYQSDIFETRLLGQKVICMSGEEAAKLFYDTEKFQRKGAAPKRVQKTLFGENAIQTMDGEAHKHRKLLFMSLMTPERLKRLAELTMEQWEAAIDKWEKMDEVVLFDEAKEILCRAACEWAGVPLKESEVKERAEDFGAMVDAFGAVGPRHWKGRRARNRAEKWIEGIIEDVRSGKLKAPEGTALYAMAFHRDLDGNLLDTQMAAVELINVLRPIVAISTFITFSALALHEHPEYKEKLRSGDDDYLEMFVQEVRRYYPFFPFLGARVRKDFTWNGYEFKKGTLVLLDLYGTNHDPRLWENPDEFRPERFKEWKGSPFDFIPQGGGDYYKGHRCPGEWITIEVMKVSLDFLVNKIEYEVPEQDLSYSLVRMPTLPKSGFIMSNVKRKF

---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----

_

Cluster ID Size Length

CYP152_02_D

>073_DMPRLDNTLALLAKGYAWLPDRRRRAGGARVVRTRLLGARPAVALRGPDAARFFYDERHVRRHGALPEPVLSTLFGHGAVHTLDGEAHRVRKAMFLSLLMDPDPGVAALVERVTAAWDEAVAGWAGRPRVVLFDEAARVLTRAVCRWAGVPLDDDEVPALARDLVAMVDGFATAGPRHWRARRARGRREAWLARLVEDVRSGAATAPAGSALDVVARHRDADGELLDPRTAAVELLNVIRPTVAVAWFVAFAAHALHRWPEHRERLRADDSGDPAFAEAFAHEVRRFYPFAPFVGGRAVRDLEWRGERIPAGSLVLLDLYGQNHDPELWPDPYAFRPERFLGREIGRFELVPQGGGDPRTGHRCPGEDITVALLAALAVRLARLDYDVPEQDLTIPLRRIPARPRSGFVLRVVRAP
>Consensus/1-664 Percentage Identity Consensus MMCGGAPVPAGFWETPMPAAGMMTMDVLRRRPLLDSTLPLLAEGYAWLPDRRRRSGGGPAQGKMGHGESAQTEMGEAPVVRTRLLGARPAVALRGPDAVRFFYDERHVRRHGALPEPVLDTLFGHGAVHTLDGEAHRVRKALFLSLLKDPAPEGDGVAGLVEHVTAAWDEAVAEWAGEPQRPRVVLFDEAARVLTRAVCRWAGVPLDDAPDDVAGSADDGEAEAAALARDLVAMVDGFATAGPRGHWRARRARARQEARLARLVEDVRSGAVPEAGAAAPSALGTAPAGSAPANALEAVARHRDADGEPPELLDPRTAAVELLNVIRPTVAVAWFVAFAAHALHRWPEHRERLRADDPGDGGPTYGEGSGDPAYAEAFAHEVRRFYPFAPFVGGLAARDLEWRGEPIPAGTLVLLDLYGQNHDPELWPDPYAFDPERFLGDDGAAGGAAGRGAEGPGPGRDELIPQGGGDPATGHRCPGEDITVALLEALAVRLARLDYAVATPVPEEQDLRIPLRRIPTRPRSGFVLTGVRAPAPAAAAAAAAPGAAVGARRPRPRIAVHPLAGQRRRDVLQRFAFGRDGEEDGHQAGGDHQARADAEREDGVGDDAARHLGVGDGESTALRGEPAGDVADAGQRAAPRRGVLPHSQSRSADSRGRLSRRSRV
>01_D_ConsensusMLDSTLPLLAEGYAWLPDRRRRSGGGVVRTRLLGRPAVALRGPDAVRFFYDERHVRRHGALPEPVLDTLFGHGAVHTLDGEAHRVRKALFLSLLKDPDGVAGLVEHVTAAWDEAVAEWAGRPRVVLFDEAARVLTRAVCRWAGVPLDDDEAEALARDLVAMVDGFATAGPRHWRARRARARQEARLARLVEDVRSGAVPTAPAGSALEAVARHRDADGELLDPRTAAVELLNVIRPTVAVAWFVAFAAHALHRWPEHRERLRAGDPAYAEAFAHEVRRFYPFAPFVGGLAARDLEWRGEPIPAGTLVLLDLYGQNHDPELWPDPYAFDPERFLGREPGRDELIPQGGGDPATGHRCPGEDITVALLEALAVRLARLDYTVPEQDLRIPLRRIPTRPRSGFVLTGVRAP
---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----

_

Cluster ID Size Length Ident Class

CYP152_03_B

>003_BMPAIPRDPSLDSTLALLADPYRFISRRCRRLGSDVFETRLLLRPTICMTGPEAAALFYDPARFQRAGAAPEPLRATLFGKGGVQGLDGEAHRHRKALFMALMAPERVAALAERVAREWERAARRWAAAADRVVLYDALQELLTRAVCAWAGVPLPEAEVPRRTRQLTALFDAAAAGGLGHLFRSRAARRRAEAWLAGLIEDIRAGRLAPPEDSAAHAIAWHRDLDGRLLPPRVAAVELLNVLRPTVAVSVYIVFVAHALHAHPECRARLAAGDGGYADAFVQEVRRFYPFFPAVAARVREDFEWRGYHFPAGRRVLLDLYGTNHDPRAWEDPEAFRPERFLGRDPGPFDFVPQGGGDPATGHRCPGEGIAVELMKLALDFLLRRLRYEVPEQDLALDMSRLPALPRDGFVIRDVRPRA
>Consensus/1-615 Percentage Identity Consensus MNEHNGHPSPAHTSFDEFWQYYLREHSSGLNRALHLTGTAAALVLAGTALVRRKPRLLLLAPLVGYAPAWFGHFVVERNRPASFHSPLWSLRADLRMLRLAVTGRLNDALPRDDAAMGHAAPMKRSIKMMPEIPRDKGLDSTLALLRDPYRFISRRCRRLGSDVFETRLLLRKTICMTGAEAARLFYDPDRFVRAGAAPERIQKTLFGEGGVQGLDGEAHRHRKAMFMSLLMTPERIEALAELTEREWRRRARDWARMGEQVVLYDELQELLTRAVCAWAGVPLPEAEVPRRTRQLTALFDAAGAVGPRHLWRARLARRRAEAWLAGIIEQIRAGRLQPAAARPHAWPASRAARAAAPAAAAAPPEESAAHVIAWHRDLDGALLPPRVAAVELLNVLRPTVAVSVYITFAAHALHRHPEWRERLADEDGSGDDGDPDDPGYLEAFVQEVRRFYPFFPAVAARVREDFEWRGYRFPKGRRVLLDLYGTNHDPRLWDEPEEFRPERFREGDRDPQSPFDFIPQGGGDHHTNHRCPGEWIAIELMKVALRFLTREMRYEVLPREQDLRIDLDFSRLPALPRSRFVIRNVRRRERSLKATSASSMGRVRILHPSIHSKA
>08_B_Consensus MPEIPRDKGLDSTLALLRDPYRFISRRCRRLGSDVFETRLLLRKTICMTGAEAARLFYDPDRFVRAGAAPERIQKTLFGEGGVQGLDGEAHRHRKAMFMSLMTPERIEALAELTEREWRRRARDWARMEQVVLYDELQELLTRAVCAWAGVPLPEAEVPRRTRQLTALFDAAGAVGPRHWRARLARRRAEAWLAGIIEQIRAGRLQPAPEESAAHVIAWHRDLDGALLPPRVAAVELLNVLRPTVAVSVYITFAAHALHRHPEWRERLASGDPGYLEAFVQEVRRFYPFFPAVAARVREDFEWRGYRFPKGRRVLLDLYGTNHDPRLWDEPEEFRPERFRDRDPSPFDFIPQGGGDHHTNHRCPGEWIAIELMKVALRFLTREMRYEVPEQDLRIDFSRLPALPRS
---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----

_

Cluster ID Size Length

CYP152_04_P

>007_PMEIPRDAGLDSTLAFLREGYRFIGRRCDALGSDAFRTRLMLRPVVCMRGEEAARLFYDGDRFTRAGAMPPTTLRLLQDKGSVQALDGAAHRHRKALFLSLMTGEAIERIGDLFERRWRAALPRWRGQGEVVLHDAMGEVLCRAACDWAGVPLEEEELRRRTRELAAMIDGAGSVGPRNWRALALRRRAERWARALVAAVRDGRLAVPEGSALARIARHRDLDGRLLDLEVAGVELLNLLRPTVAVARFIVFAALALHQHPAWRAALASGDEADLEPFVQEVRRFYPFFPVIGGRVRQPFDWRGHRFARGDWVLLDLYGTNHDPRLWEAPEAFRPERFRDWEGDAFALIPQGAGDHASGHRCPGEWITIALLERAVRLLCGAARYRVPPQDLSIPLDRFPTLPRSGLVLE
>Consensus/1-525 Percentage Identity Consensus MIADDNPAEQPARTSFVPTMGNARRLHRFEFSGGGTSAMSMSAPARLALPVMATIPRDRSPDSTLAFLRNEGYRFIGRRCDRLGSDIFQTRLLLLRPVICLRGREAARLFYDPDRFTRRRGAMPPRVQRLLQDRGSVQGLDGAAHRDRKAMFMSLMTPAAIRQRLGQLFDDEWRARIPRWEGQRAGPVVLYDEVGRVLTRAVCAWAGVPLAEAEAEVARRTAELHAMIEGAGAVGPRHWRGLLLRRRTERWARDLVERVRAGALPDAAPEGDAEGSALAVIALEHRDAVDGNGGDGDGRLLPRRIAAVELLNVLRPTVAVARFIVFAALALHDHPAWRDRLARAGATDDAALEAFVQEVRRYYPFFPVAAGRVRAGRPFDWRGHHFPRGDWVLLDLYGTNHDPRLWPEPAERFRPERFAGWRGADDDPFGLVPQGGGDHATGHRCPGEWITIELMKRAVRLLTGAMRYDVPPQDLAVDLRRMPALPPSGFVITNVRRTAAARAADGVRPARSARAHLPESRSRKA
>09_P_Consensus MATIPRDRSPDSTLAFLREGYRFIGRRCDRLGSDIFQTRLLLRPVICLRGREAARLFYDPDRFTRRRGAMPPRVQRLLQDRGSVQGLDGAAHRDRKAMFMSLMTPAAIRRLGQLFDDEWRARIPRWEGAGPVVLYDEVGRVLTRAVCAWAGVPLAEAEVARRTAELHAMIEGAGAVGPRHWRGLLLRRRTERWARDLVERVRAGALPAPEGSALAVIAEHRDADGRLLPRRIAAVELLNVLRPTVAVARFIVFAALALHDHPAWRDRLRAGDDAALEAFVQEVRRYYPFFPVAAGRVRRPFDWRGHHFPRGDWVLLDLYGTNHDPRLWPEPERFRPERFAGWRGDPFGLVPQGGGDHATGHRCPGEWITIELMKRAVRLLTGAMRYDVPPQDLAVDLRRMPALPPSGFVITNVRRTA
---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----

_

Cluster ID Size Length

CYP152_05_M

>209_MMKEVPETKIKLTDVKELLDKGYNLLGELREEADAPVVKAKFLNKEIIAIYGEEAAKKFYDPRNFKREGAMPKPVLKTLFGEDGVQTLDGKEHHHRKNIFMDLMTPERMEDYHRILDRNLSEELDKQHGEFELFDLAKDVLFRSICEWAGINLAKYSKEEIDQLADYQISMISGAVTSPTDHIKGIEDRKKSEKWAQELIEEARENPVPGKENVALYAFANATDLDGELLPIEVAAVELLNIIRPTVALTVWVALMGHALFSRPDIYQELKADFDELQDSFIQEMRRYYPFFPMLPAIALQDVEIDGYLIPKDSWVVLDLYGTNHDERTIESPESFDIKRYVGKAKDISYEEEYEMIAQGGGKFREMHRCAGEWITLHSLRVFSDQLVNKYEFSVPEQDWTIPMNQFPTYPNSKALLFKE
>Consensus/1-430 Percentage Identity Consensus MMAMKEVPEVKIKLTDVKELYNKGYNLLGELREEADAPVVKAKFLNKEAIAIYGEEAAKKFYDPRNFKREGAMPKLVLKTLFGEDGVQTLDGAAHHHRKNIFMDLMTPERMEDYHRILDKNLTQELDQQHGQFELFDLSKDVLFTSICEWAGINLAQYSKEEIDKLADYQISMISGAVTSPIDHIKGVENRKKSEKWAQSLIEEARKNPVAGKENVALYAFANATDLDGELLPIEVAAVELLNIIRPTVALTVWAALMGHALFSRPDLYQQLKNDFDTLQDSFIQEMRRYYPFFPMLPAIALQDVEVDGYLIPKDSWVVLDLYGTNHDERTIEAPESFMIKRYVGKAKDISYEEEYEMIAQGGGDFRQMHRCAGEWITLHSLRVFSDQLVNKYEFSVPEQDWTIPMNQFPTYPNSKALLYKEAAMTTENE
>06_M_ConsensusMKEVPEVKIKLTDVKELYNKGYNLLGELREEADAPVVKAKFLNKEAIAIYGEEAAKKFYDPRNFKREGAMPKLVLKTLFGEDGVQTLDGAAHHHRKNIFMDLMTPERMEDYHRILDKNLTQELDQQHGQFELFDLSKDVLFTSICEWAGINLAQYSKEEIDKLADYQISMISGAVTSPIDHIKGVENRKKSEKWAQSLIEEARKNPVAGKENVALYAFANATDLDGELLPIEVAAVELLNIIRPTVALTVWAALMGHALFSRPDLYQQLKNDFDTLQDSFIQEMRRYYPFFPMLPAIALQDVEVDGYLIPKDSWVVLDLYGTNHDERTIEAPESFMIKRYVGKAKDISYEEEYEMIAQGGGDFRQMHRCAGEWITLHSLRVFSDQLVNKYEFSVPEQDWTIPMNQFPTYPNSKALLYKE

---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----

_

Cluster ID Size Length

CYP152_06_N

>101_NMAEHQSIPKDKGLDHTLELLKEGYTFILNRSNKFDSRVFETRLLGEKVICLVGEEEAELFYDNDKFRRKDAAPGRIQKTLFGEGGVQGLDGEAHHHRKAMFMSLMTKDSLEEIRSLTREEWKRALSRWNSKEEVKVYDAAKKVLTRVALRWTGVPFKDEEAEEWADELSDLFESAAAVGPKHWKARRSRSKAEEWLEDLVEKVRKEKIEVDKDRALYQFSWHRDENGELLDKHIVAVELLNLLRPIVAISVYIDFTVLALHDYPEEVEKLREGDEELQYFIQEVRRYYPFFPFAAARVKQDFTWNGYEFKEGTLTLLDLYGTNHDPAIWENPDQFKPERFKNWKGSPFDFIPQGGGEFDIGHRCAGEWITIDILKETLDFFVNEISFDFPEQDLGYSMNDIPSLPKSGIIITNIQK
>Consensus/1-431 Percentage Identity Consensus MMAMHKSMPKEEGLDHTLSLLKEGYLFIMNRRKSFQSNVFETRLLGEKAICLTGKEAAELFYDNDKFKRKGAAPKRLQKTLFGEGGVQGLDGEAHRHRKAMFMSLMTKDSLEEITKLTREEWERALEKWESEDEIVLYEEAKKVLTRVACEWTGVPLQEEEVEKRTDQLSDLFESAAALGPKHWKGRRSRSKAEEWIEDLVEEVRNGKLEVDEDRALYQFSWHRDENGELLDKEVVAVELLNLLRPIVAISVYIAFTALALHQFPEEAEKLKGGDEGDDDELQWFIQEVRRFYPFFPFTAARVKQDFEWNGYEFEEGTLTLLDLYGTNHHPDLWENPDTFNPERFKDWQGSPFDFIPQGGGEFDIGHRCAGEWVTIDIMKETLDFLVNHLEYDVPEQDLSYSMNDIPSLPKSKVKLTNIRRKKNDGLHRAT
>12_N_ConsensusMHKSMPKEEGLDHTLSLLKEGYLFIMNRRKSFQSNVFETRLLGEKAICLTGKEAAELFYDNDKFKRKGAAPKRLQKTLFGEGGVQGLDGEAHRHRKAMFMSLMTKDSLEEITKLTREEWERALEKWESEDEIVLYEEAKKVLTRVACEWTGVPLQEEEVEKRTDQLSDLFESAAALGPKHWKGRRSRSKAEEWIEDLVEEVRNGKLEVDEDRALYQFSWHRDENGELLDKEVVAVELLNLLRPIVAISVYIAFTALALHQFPEEAEKLKGGDEDELQWFIQEVRRFYPFFPFTAARVKQDFEWNGYEFEEGTLTLLDLYGTNHHPDLWENPDTFNPERFKDWQGSPFDFIPQGGGEFDIGHRCAGEWVTIDIMKETLDFLVNHLEYDVPEQDLSYSMNDIPSLPKSKVKLTNIRRK

---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----

_

Cluster ID Size Length

CYP152_07_O1

>206_O1MAALLRDDSPSLLTRGYGFGARIWRRVRPGARSAPMRLLGRDALLVRGAEGVELFYDESRIARHGAMPAIVQETLFGHGSVHSLDGDEHRHRKATFVDVAYEDEQVARLTPLLEREWRRELDAWLAGGTRSAYDAAVGAFGRAIMRWAGLPGTPAAKTRWAARLAQIVDGFGVPYSPEYLLALANRWWSDRHAARLIEAVRAGALDAAEGTALHEWAWHRDRDGELLPARLAGIELQNSIRPMIAVARFVAFAAKELHDRPEWRERIAAETAERGSLVGGPLATAFAQEIRRTAPFVPMLPGWATTDVELDGQRVPAGGRVVLDILGTDTDDRSWERADRFDPERFVGVDYEALAAFIPHGGADVATGHRCPGEKLAIAGLAAAIAALSDPRLTILDEGLDVNRRRLPTKPASGGRVRAAGAPSRCPFH
>Consensus/1-522 Percentage Identity Consensus MPLAGYRGRCDGQGMSTADALATAVPSTMLQRLATSRSMAAMAAMLIDDSLSLLTRGYGFGAHIWRRARPAGARAVPMRLLGRPALLVRGAEGVELFYDESRIARHGAMPAIVQETLFGHGSVHSLDGAEHRHRKATFVDVAYEDEQVERLTPLLEREWRRELDAWLAGGHTRSAYDAAVGAFGRAIMRWAGLPGTPAAKTRWAARLAQIVDGFGVPYSPEYLLAVLNRRWSDRHAARLIEAVRAGRLDPAEGTALHEWAWHRDRSGALLPARLAGIELQNSIRPMIAVARFVAFAAKELHDRPEWRERIAAETAERDTADGPRVDGPRVDGPRVDGPLAVGSLVGGPLATAFAQEIRRTAPFVPMLPGWATTDVELDGERVPAGGRVVLDILGTDTDERSWERADRFDPERFLGVDSWDDYEAITTFVPHGGADVATGHRCPGEKLAIAGLAAAVAVLSDPRLTILDEGLDVNRRRLPTKPASGGRVRAAGARGRSATGGRSAAAGGRCPFHRGAHHRTLS
>03_O1_ConsensusMAAMLIDDSLSLLTRGYGFGAHIWRRARPGARAVPMRLLGRPALLVRGAEGVELFYDESRIARHGAMPAIVQETLFGHGSVHSLDGAEHRHRKATFVDVAYEDEQVERLTPLLEREWRRELDAWLAGGTRSAYDAAVGAFGRAIMRWAGLPGTPAAKTRWAARLAQIVDGFGVPYSPEYLLAVLNRRWSDRHAARLIEAVRAGRLDPAEGTALHEWAWHRDRSGALLPARLAGIELQNSIRPMIAVARFVAFAAKELHDRPEWRERIAAETAERGSLVGGPLATAFAQEIRRTAPFVPMLPGWATTDVELDGERVPAGGRVVLDILGTDTDERSWERADRFDPERFLGVDDYEAITTFVPHGGADVATGHRCPGEKLAIAGLAAAVAVLSDPRLTILDEGLDVNRRRLPTKPASGGRVRAAGAAGGRCPFH
---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----

_

Cluster ID Size Length

CYP152_08_New

>Consensus/1-461 Percentage Identity Consensus -----------------------------------------MFVDSIL--VLRLEFL---------KTGII-LEIKNEGIKMAKRIPKDKGLDNTLKVMKEGYEYVPNRLEKFNT-------DNIFETRVLGGKRAVVISGKEAAELFYDNDKIERKGTLPKRVVNTLFGKGAIHTTTGKKHIDRKALFMSLM-TEENL---------------------------------------------------KYLRELTRNYWFMNT-ERMQQMDE-VNVYKESIILLTKVGFRWAGIPIATP--------EEIEQIAKDMDIMIDSFKGL-GTAYGKGYR----EAKKARARVEDFLEDQIIAVRKGKIH-------PEEGTALYE-FAHWEDMNGNPMDSRLCAVDLMNVIRPLVAINRFVSFGVLAMHEFPGEREKVAV--TNDPD---------YAYKFAQEVRRYYPFVPFLPGKAKKDIEFDGYKIKKDTMLILDIYGTLHREDLFENPERFNPERFENWD----------GSPFDLIPQGGGDYYTNHRCAGEWMTIIIMEETMKYFANEIDYDVPKPQDLTVDLTKLPGKVKSGMIIE--NVRPNVDRTKESV
>15_New_ConsensusMAKRIPKDKGLDNTLKVMKEGYEYVPNRLEKFNTNIFETRVLGGKRAVVISGKEAAELFYDNDKIERKGTLPKRVVNTLFGKGAIHTTTGKKHIDRKALFMSLMTEENLKYLRELTRNYWFMNTERMQQMDEVNVYKESIILLTKVGFRWAGIIATPEEIEQIAKDMDIMIDSFKGLGTAYKGYREAKKARARVEDFLEDQIIAVRKGKIHPEEGTALYEFAHWEDMNGNPMDSRLCAVDLMNVIRPLVAINRFVSFGVLAMHEFPGEREKVAVNDPDYAYKFAQEVRRYYPFVPFLPGKAKKDIEFDGYKIKKDTMLILDIYGTLHREDLFENPERFNPERFENWDGSPFDLIPQGGGDYYTNHRCAGEWMTIIIMEETMKYFANEIDYDVPPQDLTVDLTKLPGKVKSGMIIENVRPNVDRT
---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----

_

Cluster ID Size Length

CYP152_09_O2

>207_O2MTSPVPRLRSEQSLNFLRSGYLFASRVRRKAGVAPDSHTPVRLRLLGKKATLVRGEEGVRFFYDEDKVKRDGAMPKFIQGPLFGKGAVHGLDGEAHKVRKNAMADMAYDDEARVAAFKPLVAEELEAMLDRWARAGPAMPGNVYDDTALAFGRAAFRWAGIPLSDEEMDRRARQMSRLLDTFGRPATGNPVAWVERRRLDRWATQLIEDVRSGRVTADPDSVLAHMADLRDENGELVDAKTAGIELQNLTRPTVAVARFAAFAAVALVEHPEWAERIRAASEAAGGRLIDIPEAVAFAQEVRRTYPFVPMLPALATEDTEVSGCPVHKGQRVLLDILGTNTSPAEWEDAGTFDPERFLGYAGVETLEDAEAIEAFIPQGGADVRTGHRCPGEKIAVTALSAAVAALCRPEVRISDDQEDTTFSWTQMLTRPATGVRVSVAGRSAATA
>Consensus/1-460 Percentage Identity Consensus MDTNNKINESDDMMTSPFGRTRSEQGLSFLRSGYLFASRVRRRAGLSPDSGCPVRMPLLGKKAVLVRGEEGVRLFYDTSRVKRDGAMPGFIQGPLFGAGAVHGLDGEAHRVRKNQMADMAYEDEARVAAFKPLVAEELEALLARWKDGGPAMPGNVYDDTALAFGRAAFRWAGIPLSDEEMDRRARRMSRLLDTFGRPAPTNPVAWLERIRLDRWATALIEDVRSGRVTADPDSVLAHMADLRDENGELVDAKTAGIELQNLTRPTVAVARFAAFAAVALVEHPEWAERIRAASEARGGRLLDVPEAVAFAQEVRRVYPFVPMLPAEATEDTEISGCPVHKGQRVLLDILGTNTDPASWDRAATFDPERFLGVEGVETQEDAEAIETFIPQGGADVRTGHRCPGEKIAVTALSAAVVALCRPEVQISSDQDDLTFSWTHMLTRPATGVRVRVARRSAATA >04_O2_ConsensusMTSPFGRTRSEQGLSFLRSGYLFASRVRRRAGLSPDSGCPVRMPLLGKKAVLVRGEEGVRLFYDTSRVKRDGAMPGFIQGPLFGAGAVHGLDGEAHRVRKNQMADMAYEDERVAAFKPLVAEELEALLARWKDGGGNVYDDTALAFGRAAFRWAGIPLSDEEMDRRARRMSRLLDTFGRPATNPVAWLERIRLDRWATALIEDVRSGRVTADPDSVLAHMADLRDENGELVDAKTAGIELQNLTRPTVAVARFAAFAAVALVEHPEWAERIRAASEARGGRLLDVPEAVAFAQEVRRVYPFVPMLPAEATEDTEISGCPVHKGQRVLLDILGTNTDPASWDRAATFDPERFLGVEDAEAIETFIPQGGADVRTGHRCPGEKIAVTALSAAVVALCRPEVQISSDQDDLTFSWTHMLTRPATGVRVRVAR
---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----

_

Cluster ID Size Length

CYP152_10_R

>006_RMTDIPRDDHLESSLALLREGYPFIRDRCQRLHSDVFQTRLLLQNTICLSGEEAARLFYDERLFQRAHAAPRMLQKTLFGQGGVQGLDGEAHRQRKRMFLQLLDAAAVAELVRLAEQEWRAAIETWQARGEVVLLPEVQLILTRSVCRWAGVPLAPAEVEIRRDQLAAMIDGAGGIGARHWAARKARREAEAWAAGLIEQVRAGELQAAPTSALAVVAHHRDLDGELLDERVAAVELLNLLRPTVAVSRFIIYAALELLAHPQWRERLRADDALLEPFAQEVRRLHAFFPFTAARVREDFEWQGYHFPAGTRVLLDLYGTNRDPRRWEDPEAFQPERFVDWDGNAFSFITQGGGDAAEGHRCPGERLAIELLKLALRMLTREMTYAVPAQDLRIDLSRMPAQPESGLVISDVRRVAC
>Consensus/1-426 Percentage Identity Consensus MSDIPRDPHLESSLALLGEGYPFIRDRCQRLGSDVFQTRLLMQNTICLSGEEAARLFYDERLFQRAHAAPRMLQKTLFGQGGVQGLDGEAHRHRKRMFMSLLDPAAVAELVRLSEQEWRAAIETWQARDRVVLLPEVQAILTRAVCRWAGVPLAEAEVAQRRDQLAAMIDGAGGIGARHWRARKARKEAEAWLADLIEQVRAGELPADPTSALAVVAHHRDLDGALLDERVAAVELLNLLRPTVAVARFIIYAALELLAHPQWRERLRQGDDAALEPFAQEVRRLHAFFPFTAARVREDFEWQGYHFPKGTRVLLDLYGTNRDARLWEDPEAFDPERFLTWDGNAFNFITQGGGDAAEGHRCPGERLAIELLKSALRMLTREMTYAVPAQDLRIDLSRMPAQPESGLVISDVRPVARTRASVSQPR
>13_R_ConsensusMSDIPRDPHLESSLALLGEGYPFIRDRCQRLGSDVFQTRLLMQNTICLSGEEAARLFYDERLFQRAHAAPRMLQKTLFGQGGVQGLDGEAHRHRKRMFMSLLDPAAVAELVRLSEQEWRAAIETWQARDRVVLLPEVQAILTRAVCRWAGVPLAEAEVAQRRDQLAAMIDGAGGIGARHWRARKARKEAEAWLADLIEQVRAGELPADPTSALAVVAHHRDLDGALLDERVAAVELLNLLRPTVAVARFIIYAALELLAHPQWRERLRQDDAALEPFAQEVRRLHAFFPFTAARVREDFEWQGYHFPKGTRVLLDLYGTNRDARLWEDPEAFDPERFLTWDGNAFNFITQGGGDAAEGHRCPGERLAIELLKSALRMLTREMTYAVPAQDLRIDLSRMPAQPESGLVISDVRPVAR
---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----

_

Cluster ID Size Length

CYP152_11_L

>077_LMKVKTPIPRAKGLDNTLSLIKEGFHFLPNRRKELGSDIFETRLLGQKAICIAGEEAAELFYDNDKFKRKGAMPKPLKKSLLGEGGVHGMDGEAHKHRKRMFLSMMTPERLEDMKRIAIEELDAKADEWEKKDEVVLFDEMQEILTRAGCRWAGVPLKEEEVKQRTEELVAMVDSFGGSLSRFKEGKKARESHEKWLKGIIKDIRKGKYNPPPYTAAYIVAHHREPNGKLLDLHTAAVELNNAYRPLLATAYFIVFGALAMHEHPETREKLKEDAENNYSHMFAQEVRRYYPFAPAMAAKVKKDFTWHGYKFKKNTLVVLDLFGTNRHPDSWENPDEFIPERFKNWKGSPFSFVPQGGGDHHIGHRCAGEWLTVMVMRAFFKYFAENITYDVPEQDLSYDMERMPTFPKSGFIITNVKKLKDSPENLIEDEQSQTVIRS
Consensus/1-459 Percentage Identity Consensus MSNRTGFTQCERGCCRMKVKTPIPKAKGLDNTLSLIKEGFHFLPNRRKELGSDIFETRLLGKKAICIAGEEAAELFYDNDYFKRKGAAPKPLKKSLLGEGGLHGMDGEDHHHRKRMFLSMMTPERLEDLKRMAIEELDAKADEWEKMDEVVLFDEIEEILTRAGCHWAGLPLKESEVKQRTQELVAMVDSFGGSLSRFKEGKKARESHEKWLKGIIKDIRKGKYNPPPYTAAYIVAHHREPNGKLLDLHTAAVELNNAYRPLLATAYFIVFGALAMHEHPETREKLQADAENNYSHMFAQEVRRYYPFAPAMAAKVKKDFTWHGYHFKKNMLVVLDLFGTNRHPDSWENPDEFIPERFKNWKGSPFSFVPQGGGDHHTGHRCAGEWLTVMVMRSFFKYFAENITYDVPEQDLSYDMERMPTMPKSRFIITNVKKLKDSPENLIEHEQSQTVIRSGCPFH
>07_L_ConsensusMKVKTPIPKAKGLDNTLSLIKEGFHFLPNRRKELGSDIFETRLLGKKAICIAGEEAAELFYDNDYFKRKGAAPKPLKKSLLGEGGLHGMDGEDHHHRKRMFLSMMTPERLEDLKRMAIEELDAKADEWEKMDEVVLFDEIEEILTRAGCHWAGLPLKESEVKQRTQELVAMVDSFGGSLSRFKEGKKARESHEKWLKGIIKDIRKGKYNPPPYTAAYIVAHHREPNGKLLDLHTAAVELNNAYRPLLATAYFIVFGALAMHEHPETREKLQADENNYSHMFAQEVRRYYPFAPAMAAKVKKDFTWHGYHFKKNMLVVLDLFGTNRHPDSWENPDEFIPERFKNWKGSPFSFVPQGGGDHHTGHRCAGEWLTVMVMRSFFKYFAENITYDVPEQDLSYDMERMPTMPKSRFIITNVKKLKDSPENLIEHEQSQTVIR
---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----

_

Cluster ID Size Length

CYP152_12_O4

>Consensus/1-497 Percentage Identity Consensus -----------------------------------------------------MEAPDPIRQ---RRAGNGWTDRPAMRTTMPTVHARTMLKDRTVDLLRRGYTFTDWARARAGDPAAARRPPRAVPVRLLG-RPALLVRGPEGVRLFYDTTLMRRRGAMPAAVAAPLFGRGAVHGLDGDEHRHRKAMFLDALMDPARV---------------------------------------------------ADLVDLADREWARALIRVWRGGGT-GVVYDAAVEVYGRAVLRWAGVD-VPDMSEIPDLQAQADRRARRLAAIVDGFGVP-GPPY----L----RAWAARRWCDRWAAELVRRAREGERTAECAGRGPPASSVLEL-VAAHRDTDGQLLPAHTAAVELQNVLRPTVAVARFAAFAALALHEHPEWRARLRA----EVAERGSAVGGPLATAFAHEVRRLYPFVPLLAARARQPLEWGGHPVRAGQRVLLDVLGTNHDPGEWERPDAFDPERFLGTDADPWDDELDLEWAENFVPQGGGRPETGHRCPGEPVTVGLLALTAAHLAG-LDWRLDRSQGLGFDLGRMPTRPAGGVVLT--LVDRAPAPGCPVGSQPGS
>20_New_ConsensusMLKDRTVDLLRRGYTFTDWARARAGDPAAPRAVPVRLLGRPALLVRGPEGVRLFYDTTLMRRRGAMPAAVAAPLFGRGAVHGLDGDEHRHRKAMFLDALMDPARVADLVDLADREWARALIRVWRGGGTGVVYDAAVEVYGRAVLRWAGVDVPDMAQADRRARRLAAIVDGFGVPGPPYLRAWAARRWCDRWAAELVRRAREGERTPPASSVLELVAAHRDTDGQLLPAHTAAVELQNVLRPTVAVARFAAFAALALHEHPEWRARLRAEVAERGSAVGGPLATAFAHEVRRLYPFVPLLAARARQPLEWGGHPVRAGQRVLLDVLGTNHDPGEWERPDAFDPERFLGTDAEWAENFVPQGGGRPETGHRCPGEPVTVGLLALTAAHLAGLDWRLDSQGLGFDLGRMPTRPAGGVVLTLVD
---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----

_

Cluster ID Size Length

CYP152_13_C

>091_CMSNDDARGEAAPATPACGRELPRDPGLDASMALLREGYGFISNLCDRLDSDGFRARIMLREVICLRGPEAARLLYGAEGLTRVGAMPSTVLHLLQDKGSVQQLDGPAHRHRKALFLRICMDPARVEALRAEFRAAWRAALAEWEEEAEIVLQQEAARVLTRAACRWAGLADQPEARLADEIFDMIDKAGSFGPRNWLALMRRSGTERRLRGLIAAVRAGEVAPAAATALHAIAFHREADGALLDDAVAAVELLNLLRPIVAVGRYIAFAALALHREPGWRDLFRSGNLELAADFAEEVRRAAPFFPFTAAVTTRPLTWEGYDLPAGQWLLLDLYGTLHDARHFPDPAAFRAERMLSWRGQDDSFVPQGGGDVARTHRCPGEMITVELMKEAIRLLCCEMDYEVPPQDLGVALNRLPAQPASGMRLRAIRRRAGTEACRAG
>Consensus/1-446 Percentage Identity Consensus MTTDEGRDARREEEPGTPASPREIPRDPRLDATLALLREGYRFIPNRCDRLDSDAFRTRLMLREVICLRGPAAARLLYGAEGLTRVGAMPSTVLHLLQDKGSVQQLEGPAHRHRKALFLRILMEDPARVEALVAEFRAAWRERLPAWEAEGEIVLQQEAARLLTRAACRWAGLPHQIPEAARLARELFDMIDKAGSFGPRNWLALMRRRGTERRLRALVEEVRAGEVVPEAATPLHAIAFHREEDGALLDPSVAAVELLNLLRPIVAVGRYITFAALALHREPTWRELFRSGNLELAGDFAEEVRRASPFFPFTAAVTTRPVEWEGHDLPEGQWLLLDLYGTTHDPRHFPEPTAFRPERMLSWRGQDDAFVPQGAGDVARTHRCPGEMITVELMKEAIRLLCCEMDYEVPPQDLGVRLNRMPAQPRSGMILSAIRRRAGTEASRDG
>11_C_ConsensusMTTDEGRREEEPGTPASPREIPRDPRLDATLALLREGYRFIPNRCDRLDSDAFRTRLMLREVICLRGPAAARLLYGAEGLTRVGAMPSTVLHLLQDKGSVQQLEGPAHRHRKALFLRILMDPARVEALVAEFRAAWRERLPAWEAEGEIVLQQEAARLLTRAACRWAGLPHQIPEAARLARELFDMIDKAGSFGPRNWLALMRRRGTERRLRALVEEVRAGEVVPEAATPLHAIAFHREEDGALLDPSVAAVELLNLLRPIVAVGRYITFAALALHREPTWRELFRSGNLELAGDFAEEVRRASPFFPFTAAVTTRPVEWEGHDLPEGQWLLLDLYGTTHDPRHFPEPTAFRPERMLSWRGQDDAFVPQGAGDVARTHRCPGEMITVELMKEAIRLLCCEMDYEVPPQDLGVRLNRMPAQPRSGMILSAIRRRA
---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----

_

Cluster ID Size Length

CYP152_14_New

>170_QlikeMTQAVPPPSARPAAAGIPALPGLDATARLLRDGYLFGTRGFRDVGADAFRTRLLGRPVVVARGAEAAHFFGEGGRFDRAGAIPRSVLHLLQDEGSVQTLEGERHRERKRLFLDLAEEERAGLVSAFRDAWPASAAEHAGGPVPLQDVAAEALTRAALAWVGIALDEEEEEALSDELRSMIDNAGRVGPPNWAARLRRRRTEAWARELIRDARAAGDAATIAGRIAHHEEDGRLLDEEVAAVELLNLLRPTVAVARFVAFAAHALHRHPDWRERIRGGEEARTRAFADEVRRFYPFFPMIGGRATRPLELHGERLPAGQWMLLDLYGTDHSPELWEAPDVFDPGRFATASPNAVVAQGAGDPLAAHRCPGELATVDLLAAALELLTAGHPYDVPEQDLRISLRRFPAEPEDGMVVTFA
>Consensus/1-508 Percentage Identity Consensus MSTPPTVRPRNAAPTCAMWAATTPAGPSRRMRTWVPVGSMRVGAFTLRPYWGGSVPAVVNPLSGADRAWCGGAMTQAVPPPSARPAAAGIPALPGLDSTAAVLADGYLFGTRGFDDVGADAFRTRILGRPVVVARGIEAARFFYEGGRFDRGAGALPGSVLHLLQDEGSVQTLEDERHRRRKRLFLDLVETAEERSRLVSAFADEWQASAARFAGEDPVPLQDVAAEVLGRAVLAWAGIALDEEEALARSDELRSMIDNAGRFGPPNWAARLRRRRATERWARGLIEASRAAGDPPTEGAASILGRIASHHEEDGALLPEEVAAVELLNLLRPTVAVGRFVVFAALALHRHPEWRERLRDGEEAARAAFANEVRRFYPFFPMVGGRARRELEFRGETLPAGQWMLLDLYATDHSPAHWEAPDVFDPERFAAPGVDRNGFIAQGGGHYGADHRCPGEPATVDLLAAALELLTAGHPYDVEPGQDLRISLRSFPAEPEDGFVVTFRAVRA
>18_New_Ql1_Consensus/1-508 Percentage Identity Consensus AAGIPALPGLDSTAAVLADGYLFGTRGFDDVGADAFRTRILGRPVVVARGIEAARFFYEGGRFDRAGALPGSVLHLLQDEGSVQTLEDERHRRRKRLFLDLVETAEERSRLVSAFADEWQASAARFAGEPVPLQDVAAEVLGRAVLAWAGIALDEEEALARSDELRSMIDNAGRFGPPNWAARLRRRRTERWARGLIEASRAAGDPPTILGRIAHHEEDGALLPEEVAAVELLNLLRPTVAVGRFVVFAALALHRHPEWRERLRDGEERAAFANEVRRFYPFFPMVGGRARRELEFRGETLPAGQWMLLDLYATDHSPAHWEAPDVFDPERFAAPVDRNGFIAQGGGHYGADHRCPGEPATVDLLAAALELLTAGHPYDVEPGQDLRISLRSFPAEPEDGFVVTFR

---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----

_

Cluster ID Size Length

CYP152_15_New

>Consensus/1-493 Percentage Identity Consensus -MAPVF-------------GSGKSGDIWLMGPPGRTPGGRRPLRTSRTRHRSGSMGPAEARAPAHERTGKGHR-TTMAADMAAAAAPDAGGRDQSLALLRDGYRFWENLRRDDQLRL-AGADSDVVQTRLLG-ERATVIRGADAARFFYEEPALERSSALPPILVGPLFGHGAVHTLDGDAHAHRKALFNDLL-GAAAV---------------------------------------------------RDVADRAARRWDERA-PRWG--GE-VDVFEEASAVLFEAVCDWAGLA-LEP--------EGVARRARDMLAMVDGFGSPAGARQ----L----RARRARRRTEAWVEALVEEARGSG---------AEAETPLGV-VARHRDEDGELLPAHTAAVELINLLRPLVAVSWLVAGLAEAFDEWPALREALAS----GSV---------SPKAVAQEVRRTYPFVPFLAARATRDLEWEGVTIPAGTLVVLDVWGTDHDPRIWRDPEVFDPERFADRPVT----------PYNLVPQGGGSAETGHRCPGEDLTLAVLATLAPRLAE-LDATVGGPPSMRAGLRRMPPRPTCRVRVR--AATAAARDVTPDR
>17_New_Consensus MAGGRDQSLALLRDGYRFWENLRRDADSDVVQTRLLGERATVIRGADAARFFYEEPALERSSALPPILVGPLFGHGAVHTLDGDAHAHRKALFNDLLGAAAVRDVADRAARRWDERAPRWGGEVDVFEEASAVLFEAVCDWAGLALEPEGVARRARDMLAMVDGFGSPGARQLRARRARRRTEAWVEALVEEARGSGEAETPLGVVARHRDEDGELLPAHTAAVELINLLRPLVAVSWLVAGLAEAFDEWPALREALASGSVSPKAVAQEVRRTYPFVPFLAARATRDLEWEGVTIPAGTLVVLDVWGTDHDPRIWRDPEVFDPERFADRPVTPYNLVPQGGGSAETGHRCPGEDLTLAVLATLAPRLAELDATVGGPPAGLRRMPPRPTCRVRVRAAT
---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----

_

Cluster ID Size Length

CYP152_16_New

>Consensus/1-512 Percentage Identity Consensus MIAPEFHRQPDTPAPTSPHSAPHSPALPLVCSPGHTPGHDAMIVQDTR--PVQLSGGGPEAAGK--PDRMV-DAAGGGLRDAPPPIPRSPAFDETLSLLREGYGFLSRRCADLDT--------DIFRTRLML-RDVICMRGPAAARLFYDDARLTRVGAMPQTVLRLLQDKGSVQQLDGAAHRHRKAMFVRIL-MEDKG-------------------------------------------------GLDRLVAIFRRHFLERV-PDWSRMGA-VALGEEADLILFRTALAWTGAPVDAD--------DDDEDDAALLADMIENAGHF-GPRT----FPLPLGALFRRSRLERRLRAAFRAIRRGKLT-------PMPGSPLAMILAGYRDAHGELLSPEVAAVELINLLRPIVAIGRYIVFAALALERHPQWREILRA--EPDDE---------ELTDFAEEVRRISPFFPFVGAVARASFDWKGHRIRRGQWLLLDLYGTCHDEAAFPAPDEFRPGRGLRWD----------EADYSFIPQGAGSPARGHRCPGEKATVEILKEAVRLLAGVIDYRVPAEQDLSVSLSTVPAGPADGFIISIAGVAWREMEAASRR
>Consensus/1-512 Percentage Identity Consensus MPPIPRSPAFDETLSLLREGYGFLSRRCADLDTDIFRTRLMLRDVICMRGPAAARLFYDDARLTRVGAMPQTVLRLLQDKGSVQQLDGAAHRHRKAMFVRILMEDKGGLDRLVAIFRRHFLERVPDWSRMGAVALGEEADLILFRTALAWTGAPVDADDDEDDAALLADMIENAGHFGPRTFGALFRRSRLERRLRAAFRAIRRGKLTPMPGSPLAMLAGYRDAHGELLSPEVAAVELINLLRPIVAIGRYIVFAALALERHPQWREILAEPDDEELTDFAEEVRRISPFFPFVGAVARASFDWKGHRIRRGQWLLLDLYGTCHDEAAFPAPDEFRPGRGLRWDEADYSFIPQGAGSPARGHRCPGEKATVEILKEAVRLLAGVIDYRVPEQDLSVSLSTVPAGPADGFIISGVAWREMEAA

_

Cluster ID Size Length

CYP152_17_O3

>213_O3MPTMSTIRSTLGTKVDQAADLLADGYLFQERLRAESKGRDAGDGCPLDFRLLGKPALLVRGSEGVDLFYDTKRIKREGAMPLPIRGPLFGAGAVHGLDDDAHLARKAMFVKVAYDDAQVERFKPLVEDELRKAVQRWRRRPGNVYDDAVIAYGRAALRWAGIPGPDAELDVWAERLGQIVEGFGHLPLAHALAWVNRARCDAWAADLIREQRSGEINAAPGTALCEWARHRELDGSLLDAKTAGIELQNSIRPAIAVARFAAFAARALVEHPQWRERIAAEVAERGTLVDGPHAIAFAQEVRRLSPFVPMLPAFARDDFEWDGEQIKEGDRVIIDILGTNTDPNEWEEPDRFDPERFLGVDDAEAIEAFIPQGGGDVATGHRCPGEKIAVTELAATVAALCEPGVEIDPGDLDFDPTEMPTRPRSGGRVRAT
>Consensus/1-446 Percentage Identity Consensus MMMTTMSTIRSTLGTKVDQAADLLADGYLFQERLRAESKGRDAGDGCPLDFRLLGKPALLVRGSEGVDLFYDTKRIKREGAMPLPIRGPLFGAGAVHGLDDDAHLARKAMFVKVAYDDAQVERFKPLVEDELRKAVQRWRRRGPGNVYDDAVIAYGRAALRWAGIPGDDAELDVWAERLGQIVEGFGHLPLAHALAWVNRARCDAWAADLIREQRSGEINAAEGTALCEWARHRELDGSLLDAKTAGIELQNSTRPAIAVARFAAFAARALVEHPQYRERIAAEVAASRGTLVDNPHAIAFAQEVRRLSPFVPMLPAFARDDFEWDGEQIKEGQRVIIDVLGTNTDPSEWEEPDRFDPERFLGVDDAEAEAIEAFIPQGGGDVATGHRCPGEKIAVTELAATVSALCEPGVEIDPGDLDFDPTEMPTRPRSGGRVRATRQAVTAGA
>05_O3_Consensus MTTMSTIRSTLGTKVDQAADLLADGYLFQERLRASKGRDAGDGCPLDFRLLGKPALLVRGSEGVDLFYDTKRIKREGAMPLPIRGPLFGAGAVHGLDDDAHLARKAMFVKVAYDDAQVERFKPLVEDELRKAVQRWRRRPGNVYDDAVIAYGRAALRWAGIPGDDAELDVWAERLGQIVEGFGHLPLAHALAWVNRARCDAWAADLIREQRSGEINAAEGTALCEWARHRELDGSLLDAKTAGIELQNSTRPAIAVARFAAFAARALVEHPQYRERIAAEVASRGTLVDNPHAIAFAQEVRRLSPFVPMLPAFARDDFEWDGEQIKEGQRVIIDVLGTNTDPSEWEEPDRFDPERFLGVDDAEAIEAFIPQGGGDVATGHRCPGEKIAVTELAATVSALCEPGVEIDPGDLDFDPTEMPTRPRSGGRVRAT

---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----

_

Cluster ID Size Length

CYP152_18_New

>087_DlikeMRQDGALGLLRQGYGWASRLRAGRAAVPTRLLGRRAVVVGGPAGVRRFYDPRLRRRGAFPAPVKLVLFGPGSVHGLDDAEHHHRKARYLELLTPAAVDALRSRAEREWEAAARAWAPGRPVVLFDEAVRVLTATVLPWAGVPAGPDEVPRRARQLAAVLDGFARPGPPYARAAAARRRLDRWAAGLVRAARAGRLQPPPGTALDVMAQARDADGRLLPARVAGVALLNVVRPTVAVAWFVAFAGVALHEQPYWRERIAAGDDAALGAFAQEVRRRYPFVPVLAARARTDQDVLGVDVPAGGYVVLDVHGTDHDPAHWPDPDRFDPGRFLGGPVDPDTLVPQGGGALRTGHRCPGEDVTLVLLEEAVRRLALTPYELPPQDLTVDLSRVPTRPRSGVLLAVAP
>Consensus/1-451 Percentage Identity Consensus MPRAYPRPPPGMRGAPAGYLVAIDGTEGTTMRQDGALGLLRQGYGWASRLRAGRAAVPTRFLGRRAVVVGGPEGVRRFYDPRLRRAGAFPAPVKLVLFGPGSVHGLDDAEHHHRKARYLELLTPAAVDALRSRAEREWEAAARAWAPGRPFVLFDEAVRVLTATVLPWAGIPAGPDEVPRRARQLAAVLDGFARPGPPYARAAAARRRLDRWAAGLIRAARAGRLQPPPGTALDVMAQARDADGRLLPARAAAVALLNVVRPTVAVAWFVAFAGVALHHQPYWRERIAAGDDAALGAFAQEVRRRYPFVPVLAARARTDQDVLGVDVPAGGYVVLDVHGTDHDPAHWPDPDRFDPGRFLGGPVDPDTLVPQGGGALRTGHRCPGEDVTLVLLEEAVRRLALTPYELPPQDLTVDLARVPTRPRSGVLLAVAPSRDQRPSETEPSRSGHEIA
>16_New_Dl1_ConsensusMRQDGALGLLRQGYGWASRLRAGRAAVPTRFLGRRAVVVGGPEGVRRFYDPRLRRAGAFPAPVKLVLFGPGSVHGLDDAEHHHRKARYLELLTPAAVDALRSRAEREWEAAARAWAPGRPFVLFDEAVRVLTATVLPWAGIPAGPDEVPRRARQLAAVLDGFARPGPPYARAAAARRRLDRWAAGLIRAARAGRLQPPPGTALDVMAQARDADGRLLPARAAAVALLNVVRPTVAVAWFVAFAGVALHHQPYWRERIAAGDDAALGAFAQEVRRRYPFVPVLAARARTDQDVLGVDVPAGGYVVLDVHGTDHDPAHWPDPDRFDPGRFLGGPVDPDTLVPQGGGALRTGHRCPGEDVTLVLLEEAVRRLALTPYELPPQDLTVDLARVPTRPRSGVLLAVAP
---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----

_

Cluster ID Size Length

CYP152_19_New

>Consensus/1-464 Percentage Identity Consensus -----------------------------------------MTQQSD----SGADFG---------FAHID-HRPCIHMMMGRTDIPPLASLDSTLDLLREGYPYISEQCDRLGT--------DVFESRILL-KKTIFMRGEEAAELFYDDERFKREGAAPKRLQKTLFGEGGVQGLDGEAHRHRKAMFLSLM-SEARI---------------------------------------------------DELLQLVEQHWQEAL-NDWESQASPIVLLDELHRILCRAACEWAGIPTLHN--------VDAPEMTEKLVLMIEGAGAI-GPKH----W----RSRRARKQAENWAIDLIKQYREGLLE-------PDEDSALAV-IADHRDLDGKLLPLRIVAVELLNIIRPIVAVARYMVFAAHAMHEHPDCREKLRHT-SGDSD---------YRRRFIQEVRRFYPFFPFLAARVRKDFTWNGYRFKRGRQVILDLYGTNHDPKRWENPDQFYPERFEQEDVD--------GSRFNFIPQGGGDHATGHRCPGEWITLALMDLAIHKFAEQIDYDVP-EQDLTVDLNRIPARPRSGFVIS--NVRSIDKVQADAEEERFISSA
>19_New_ConsensusMGRTDIPPLASLDSTLDLLREGYPYISEQCDRLGTDVFESRILLKKTIFMRGEEAAELFYDDERFKREGAAPKRLQKTLFGEGGVQGLDGEAHRHRKAMFLSLMSEARIDELLQLVEQHWQEALNDWESQASIVLLDELHRILCRAACEWAGIPLHNVDAPEMTEKLVLMIEGAGAIGPKHWRSRRARKQAENWAIDLIKQYREGLLEPDEDSALAVIADHRDLDGKLLPLRIVAVELLNIIRPIVAVARYMVFAAHAMHEHPDCREKLRHSGDSDYRRRFIQEVRRFYPFFPFLAARVRKDFTWNGYRFKRGRQVILDLYGTNHDPKRWENPDQFYPERFEQEDGSRFNFIPQGGGDHATGHRCPGEWITLALMDLAIHKFAEQIDYDVP-EQDLTVDLNRIPARPRSGFVISNVRSIDKVQADAE
---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----

_

Cluster ID Size Length

CYP152_20_S

>019_SMALAALPQDPALDSTFSLIRKGYRFISDTCRALDTDVFRTRLLFRPVICMQGAEAARLFYDNDKFLRHGAMPARAQKTLVGVGGVQSLDGAAHRHRKHLFIRELMSPERIEALACLHRAHWHAAIAAWPIGEEMVLFDEAQKILCKSVCAWAGVPLPASELDRRAKEFGRMIDSGARLGLHHWRGRMARKSAEKWLGAEIEKIRASGEEAADSILQAFAWHRDEHGDLLPAGVAAVELINVLRPTVAIAQLAAFSALALHEYPAVRAKLENGHEDYLDWFVLEVRRFYPFFPFLAAYAREDFNWQGFEFKKGMLTLLDIYGTNHDPRCWEQPDEFIPERFKNWDQDEYGLIANGGATYEEHHRCPGEWITHRLMKVALRFLVDNLEYTVPAQDLSFSLARIPALPKSGMIIAPVAYPASLEKEHADA
>Consensus/1-428 Percentage Identity Consensus MALAALPQDPALDSTFSLIRKGYRFISDTCRALDTDVFRTRLLFRPVICMQGAEAARLFYDNDKFLRHGAMPARAQKTLVGVGGVQSLDGAAHRHRKHLFIRELMSPERIEALACLHRAHWHAAIAAWPIGEEMVLFDEAQKILCKSVCAWAGVPLPASELDRRAKEFGRMIDSGARLGLHHWRGRMARKSAEKWLGAEIEKIRASGEEGAADSILQAFAWHRDEHGDLLPAGVAAVELINVLRPTVAIAQLAAFSALALHEYPAVRAKLENGHEDYLDWFVLEVRRFYPFFPFLAAYAREDFNWQGFEFKKGMLTLLDIYGTNHDPRCWEQPDEFIPERFKNWDQDEYGLIANGGATYEEHHRCPGEWITHRLMKVALRFLVDNLEYTVPAQDLSFSLARIPALPKSGMIIAPVAYPASLEKEHADA
>14_S_Consensus MALAALPQDPALDSTFSLIRKGYRFISDTCRALDTDVFRTRLLFRPVICMQGAEAARLFYDNDKFLRHGAMPARAQKTLVGVGGVQSLDGAAHRHRKHLFIRELMSPERIEALACLHRAHWHAAIAAWPIGEEMVLFDEAQKILCKSVCAWAGVPLPASELDRRAKEFGRMIDSGARLGLHHWRGRMARKSAEKWLGAEIEKIRASGEEAADSILQAFAWHRDEHGDLLPAGVAAVELINVLRPTVAIAQLAAFSALALHEYPAVRAKLENGHEDYLDWFVLEVRRFYPFFPFLAAYAREDFNWQGFEFKKGMLTLLDIYGTNHDPRCWEQPDEFIPERFKNWDQDEYGLIANGGATYEEHHRCPGEWITHRLMKVALRFLVDNLEYTVPAQDLSFSLARIPALPKSGMIIAPVAYPASLEKEHADA
---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----

_

Cluster ID Size Length

CYP152_21_Out (No Substrate recognittion)

>Consensus/1-528 Percentage Identity Consensus --------------------------------------------------MCRQQPLGNPSPLQYIGAAGCINIMHTDA--ADAISAEPLRELPAKF---SLPLVGDTLAFVARL-RDDPAGFSLEKIKKRAHELGPVFRIDVFGKPTACFVGPEAFAIFLDDKNVAR-----------------------------AGANP--PHVEELF---LNNPEAVPFLDGEAHRRRKRLLM-QAFTAEALDGYLPTIAQVIDRYATRWKEAAAGLGAE-----------------GRFAWVPELNAMGFAIAAALFVGADPGDEDD--LPRIEAAFDDRFAAGLLSLPIRLPGTKFTR------ALQARDALLALIA--------DRAIDEHE-NPDSPSSDVLS--------------------PLRLLAAH-RDDGGDKLSRDEIRIEVINLTFHFFGAYAAVIGPGLSFLAQCLGRDPEVRARAREEILRHAE---LPAGPLDLAAIRKLEYLDRVCKESRRVAPVLPITFFGKVKRECSF-------------------DGVRIPAGHKAVGCIGASATLLDEAIYPDPGRFDPDRWLRER--ATDRQDKAWIPHGGGIHAEGHRCAGEALATLMLKVFAVRM-LRR-FDWSVPEGQDLSP--TKGKLFATPANGLQVRLTLLASDRS-DPDTAPARGITPDR
>21_New_ConsensusMAADAISAEPLRELPAKFSLPLVGDTLAFVRDPAGFLEKRAHELGPVFRIDVFGKPTACFVGPEAFAIFLDDKNVARAGANPPHVEELFNPEAVPFLDGEAHRRRKRLLMQAFTAEALDGYLPTIAQVIDRYATRWAGLGRFAWVPELNAMGFAIAAALFVGADPDEDDPRIEAAFDRFAAGLLSLPIRLPGTKFTRALQARDALLALIDRAIDEHEDSPSSDVLSRLLAARDGGDKLSRDEIRIETFHFFGAYAAVIGGLSFLAQCLGRDPEVRARAREEILRELPAGPLDLAAIRKLEYLDRVCKESRRVAPVLPITFFGKVKRECSFDGVRIPAGHKAVGCIGATLLDEAIYPDPGRFDPDRWLRATDRQDKAWIPHGGGIHAEGHRCAGEALATLMLKVFAVRMLRRFDWSVPEGQDLSPTKGKLFATPANGLQVRLTLLAS
---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----

_

Cluster ID Size Length

CYP152 (Peroxygensase)

>CYP152A1 ---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MNEQIPHDKS LDNSLTLLKE GYLFIKNRTE RYNSDLFQAR LLGKNFICMT 00500051 GAEAAKVFYD TDRFQRQNAL PKRVQKSLFG VNAIQGMDGS AHIHRKMLFL 01000101 SLMTPPHQKR LAELMTEEWK AAVTRWEKAD EVVLFEEAKE ILCRVACYWA 01500151 GVPLKETEVK ERADDFIDMV DAFGAVGPRH WKGRRARPRA EEWIEVMIED 02000201 ARAGLLKTTS GTALHEMAFH TQEDGSQLDS RMAAIELINV LRPIVAISYF 02500251 LVFSALALHE HPKYKEWLRS GNSREREMFV QEVRRYYPFG PFLGALVKKD 03000301 FVWNNCEFKK GTSVLLDLYG TNHDPRLWDH PDEFRPERFA EREENLFDMI 03500351 PQGGGHAEKG HRCPGEGITI EVMKASLDFL VHQIEYDVPE QSLHYSLARM 04000401 PSLPESGFVM SGIRRKS

Alphafold2

152A1_m3.pdb

CYP152A1.fasta

Reference

D. R. Nelson's

CYP152_Conssensus sequence

CYP152 Subcluster_Conssensus sequence

3DUMAP_DBSCAN

3DUMAP_DBSCAN

CYP152_01_A

_

CYP152_02_D

_

CYP152_03_B

_

CYP152_04_P

_

CYP152_05_M

_

CYP152_06_N

_

CYP152_07_O1

_

CYP152_08_New

_

CYP152_09_O2

_

CYP152_10_R

_

CYP152_11_L

_

CYP152_12_O4

_

CYP152_13_C

_

CYP152_14_New

_

CYP152_15_New

_

CYP152_16_New

_

CYP152_17_O3

_

CYP152_18_New

_

CYP152_19_New

_

CYP152_20_S

_

CYP152_21_Out (No Substrate recognittion)

_

CYP152 (Peroxygensase)

Alphafold2

UniRef50_O31440

284

Heme Docked

PDBj 2.1Å

Alphafold2

UniRef50_A0A176EFS7

86

Heme Docked

PDBj 1.7Å

Alphafold2

UniRef50_A0A2T5KBD0

30

Heme Docked

PDBj

Alphafold2

UniRef50_A0A5B7UMZ5

394

Heme Docked

PDBj

Alphafold2

UniRef50_A0A0H3JA76

575

Heme Docked

PDBj

Alphafold2

Heme Docked

PDBj

Alphafold2

UniRef50_A0A5B9QTQ3

17